Biotage Extrahera - Installation and Familiarization Checklist

Importance of the Topic

Installation of complex automated extraction systems demands rigorous validation to ensure performance and reliability. A structured checklist supports consistent setup, minimizes errors, and accelerates operator readiness, directly impacting analytical throughput and data quality.

Objectives and Overview

This document aims to verify completion of all installation steps and provide a condensed system familiarization. Key goals include

• Confirming proper delivery and site preparation
• Validating electrical, gas, and environmental requirements
• Ensuring functional startup and performance of solvent and pipetting subsystems
• Introducing operators to hardware and software fundamentals

Methodology and Instrumentation

Installation and familiarization proceed through sequential checklists grouped by phase:

• Shipping inspection to detect missing or damaged components
• Site readiness assessment covering N2 and air supply, mains voltage, and environmental conditions
• System unpacking, placement, leveling, and connection of utilities
• Hardware setup including pump, vacuum, solvent, and waste module integration
• System startup checks, software version verification, date/time configuration, and hardware calibration
• Functional tests such as solvent priming, pressure head and waste valve operation, and pipetting performance
• Operator familiarization encompassing hardware overview, software navigation, safety procedures, and routine maintenance

Instrumentation Used

• Biotage Extrahera automated solid phase extraction system
• Solvent pumps and feeders with five-channel solvent management
• Pressure head assembly and waste valve
• Movable pipetting head calibrated for eight-channel operation
• External vacuum pump or house vacuum connection

Main Results and Discussion

The checklist approach ensures systematic verification of each subsystem, with recorded pass/fail outcomes for solvent delivery, pressure functions, waste valve actuation, and pipetting accuracy. Operator sign-off confirms both technical installation and foundational understanding of device operation. Consistent documentation supports traceability and facilitates troubleshooting.

Benefits and Practical Applications

• Enhanced installation quality through standardized procedures
• Reduced commissioning time and minimized setup errors
• Improved operator confidence and rapid transition to routine workflows
• Comprehensive records for compliance and audit readiness

Future Trends and Applications

Advancements may include digital integration of checklists with laboratory information management systems, real-time remote monitoring of installation metrics, and augmented reality–assisted training modules. Customized analytics on installation data could drive continuous improvement and predictive maintenance strategies.

Conclusion

A rigorous installation and familiarization checklist ensures reliable deployment of the Biotage Extrahera system, promotes operator proficiency, and underpins analytical consistency. Adopting structured validation workflows enhances performance, safety, and regulatory compliance.

References

No external references cited. Internal document reference UI381.v2.