Using the GERSTEL Multi Purpose Sampler (MPS) as a large volume fraction collector

Importance of the topic

Solid phase fraction collection plays a key role in preparative and analytical workflows enabling controlled sampling from continuous streams for further purification and analysis. The adaptation of common sample handlers to fraction collectors expands the utility of existing autosamplers in process monitoring, quality control and high throughput analysis.

Objectives and study overview

This study demonstrates how a GERSTEL Multi Purpose Sampler was modified to function as a fraction collector. The aim was to enable timed collection of 20 ml fractions from an online liquid stream at one minute intervals over a defined period, and to evaluate the repeatability of fraction volumes under simulated conditions.

Methodology and instrumentation

The fraction collector capability was achieved by installing a 24 V three port switching valve on a universal syringe holder. Valve switching was controlled via the MPS Power Out event and programmed using PAL software Cycle Composer version 1.6.0 macros. A 20 ml vial tray accommodated collection vessels. A pressurized bottle supplied a constant flow stream. Sampling occurred for 10 seconds every 60 seconds, with the stream diverted to waste outside the collection window.

Main results and discussion

Over fifteen successive collections, the mean dispensed volume was 5.36 ml with a standard deviation of 0.24 ml and a relative standard deviation of 4.53 percent. This precision meets typical requirements for preparative sampling applications. The system showed reliable timing control and repeatable liquid handling over the test period.

Benefits and practical applications

• The modified MPS offers a cost effective route to large volume fraction collection using existing autosampler infrastructure
• Flexible tray configurations allow fractions up to and beyond 100 ml
• Integration with additional MPS rails can automate follow on procedures such as solid phase or liquid liquid extraction and centrifugation
• Potential online coupling with analytical instruments such as gas or liquid chromatography for real time monitoring

Future trends and opportunities

Integration of fraction collection with advanced sample preparation modules and direct hyphenation to analytical platforms will drive higher throughput and real time process analytics. Further automation using robotic interfaces or multi sampler coordination can expand sample capacity and reduce manual intervention. Emerging valve and sensor technologies may also enhance precision and enable adaptive sampling based on live measurements.

Conclusion

The study confirms that a GERSTEL Multi Purpose Sampler can be effectively adapted for large volume fraction collection. The system delivered acceptable precision under simulated conditions and offers a versatile platform for automated preparative workflows. Future enhancements can further streamline sample processing and enable seamless integration with online analysis.

References

No external literature references were included in the original text.