<div><div><p><strong>Moumita Das and Petr Bouř from IOCB Prague have demonstrated in a recent paper in the Journal of the American Chemical Society (JACS) that far-from-resonance magnetic Raman optical activity (MROA) is measurable for a wide variety of molecules and that its sensitivity does not depend on intrinsic molecular chirality. This discovery makes MROA a distinctive analytical method with potential applications in probing the conformational behavior of both chiral and achiral molecules in solution and other liquid systems.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/IOCB_Prague_Structural_sensitivity_without_chirality_Observation_of_magnetic_Raman_optical_activity_outside_resonance_5794fae70a.jpeg" alt="IOCB Prague: Structural sensitivity without chirality: Observation of magnetic Raman optical activity outside resonance" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_IOCB_Prague_Structural_sensitivity_without_chirality_Observation_of_magnetic_Raman_optical_activity_outside_resonance_5794fae70a.jpeg 245w," sizes="100vw" width="992" height="537"></p></div></div><div><p><strong>Magnetic Raman optical activity</strong> (<strong>MROA</strong>) is traditionally associated with systems fulfilling resonance conditions, i.e., those absorbing the excitation radiation. Its presence in far-from-resonance (FFR) regimes, where absorption is negligible, has not been previously reported.</p><p>In a recent study, Moumita Das and <a target="_blank" rel="noopener noreferrer" href="https://bour.group.uochb.cz/en"><strong>Petr Bouř</strong></a> from <strong>IOCB Prague</strong> identified MROA signals under FFR conditions in a range of common organic molecules. This observation challenges the established understanding of the phenomenon and suggests that MROA is more general than previously assumed.</p><p>The authors developed a theoretical description of the effect and implemented a computational protocol for simulating MROA intensities. The predicted spectral features show reasonable agreement with experimental data and reproduce observed trends.</p><p>The results further indicate that MROA spectra are sensitive not only to molecular identity but also to conformational changes. Researchers also detected this structural sensitivity in solution even when molecules lacked intrinsic chirality.</p><p>These findings position MROA as a potentially valuable analytical tool for conformational studies of both chiral and achiral molecules in liquids, with implications for spectroscopy and structural chemistry.</p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/jacs.5c22470"><strong>Structural Sensitivity without Chirality: Observation of Magnetic Raman Optical Activity outside Resonance</strong></a></h4><p>Moumita Das, and Petr Bouř</p><p><i><span><strong>J. Am. Chem. Soc. 2026, 148, 10, 11058–11067</strong></span></i></p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/jacs.5c22470">https://doi.org/10.1021/jacs.5c22470</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Magnetic Raman optical activity (MROA) has been considered to be confined to a few systems fulfilling the resonance conditions. In a far-from-resonance (FFR) case when the systems do not absorb the excitation radiation, it has not been reported. However, we find it present in many common organic molecules. The underlying theory was elaborated, and a procedure for quantum chemical simulations of MROA intensities was implemented. The spectral features predicted at the density functional theory (DFT) level reasonably agree with the observations, describe the trends in the experimental data, and allow one to understand the phenomenon more deeply. It appears that not only do molecules have specific MROA patterns but the intensities are also very much dependent on the conformation. The sensitivity to the structure in solutions without the need for intrinsic molecular chirality makes MROA a unique tool for analytical chemistry and potentially usable for conformational studies of both chiral and achiral molecules in solutions and other liquids.</p></div>

Structural sensitivity without chirality: Observation of magnetic Raman optical activity outside resonance

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<p><strong>In the week of April 27, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><div><div><div><div><div><div><h5><strong>1. Thermo Fisher Scientific: Ask the Expert: Maximizing GC Performance in Industrial Applications</strong></h5><ul><li>Tu, 28.4.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6035">Registration</a></li></ul><p>Learn how modern hardware and software workflows support industrial laboratories. Discover best practices for reliability, compliance, automation, and future-ready GC operations.</p><h5><strong>2. Restek Corporation: Air Sampling Media Selection and Analysis</strong></h5><ul><li>Tu, 28.4.2026 14:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6160">Registration</a></li></ul><p>This presentation will give an overview of the selection of air sampling media, covering both whole air and sorbent sampling techniques.</p><h5><strong>3. Agilent Technologies: FTIR in Action: From Spectroscopy Fundamentals to Oil and Grease Analysis in Water</strong></h5><ul><li>Tu, 28.4.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6049">Registration</a></li></ul><p>Learn FTIR fundamentals and practical workflows for oil and grease determination in water. Discover how ClearShot™ extraction and the Agilent Cary 630 enable fast, reliable environmental monitoring.</p><h5><strong>4. Separation Science: GC–MS Sampling Strategies for VOCs in Air</strong></h5><ul><li>We, 29.4.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6137">Registration</a></li></ul><p>Markes experts will address these challenges, exploring proven strategies to tackle complexity and achieve reliable VOC sampling using canister, sorbent tube, and online monitoring approaches.</p><h5><strong>5. Anton Paar: From Analysis to Assurance: How Thermal, Raman, and Film Extrusion Techniques Validate Crystallinity and Ensure Polymer Product Quality</strong></h5><ul><li>We, 29.4.2026 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6121">Registration</a></li></ul><p>Crystallinity strongly affects the mechanical, thermal, and barrier properties of polymer films, yet monitoring it during extrusion is difficult.</p><h5><strong>6. GERSTEL: Direct Thermal Extraction (DTE), Stir Bar Sorptive Extraction (SBSE), and Dynamic Headspace (DHS) for E&amp;L Studies</strong></h5><ul><li>We, 29.4.2026 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6148">Registration</a></li></ul><p>Explore how GERSTEL MPS with thermal desorption enables DTE, SBSE, and DHS workflows for efficient extractables, leachables, and migratables (E&amp;L/M) analysis.</p><h5><strong>7. LECO: Analysis of the Provenance of Whiskies through SPME-GCxGC-TOFMS</strong></h5><ul><li>Th, 30.4.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6150">Registration</a></li></ul><p>Discover advanced whisky profiling using HS-SPME-GCxGC–TOFMS to reveal volatile fingerprints, differentiate samples, and link chemistry to sensory character.</p></div></div></div></div></div></div>

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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