Invitation to ISC 2024 - Early Bird Registration Ending Soon!

We are delighted to invite you to the 34th International Symposium on Chromatography (ISC 2024), which will take place in Liverpool, UK, from October 6th to 10th, 2024.

The theme for the symposium is “Imagine a world of Chromatography” and the symposium programme will reflect this theme covering the many disciplines where chromatography is an essential component of the analytical workflow. This will include applications of separation science in pharmaceutical, petrochemical, environmental, food and health sectors, as well as lectures on the fundamentals aspects of separation science and new technological developments. The symposium will also highlight new challenges and emerging opportunities for both separation science and associated detection technologies.

The early bird registration is ending soon!

ISC 2024 / Marketing Liverpool: Liverpool Docks.

The information about registration, abstract submissions, the venue and an overview of the conference programme are bellow.

Sponsors 2024

• Shimadzu
• Agilent Technologies
• AstraZeneca
• BUCHI
• KNAUER
• MESTRELAB RESEARCH
• Novartis
• Restek
• YMC

ISC: Conference Sponsors 2024

Programme

The scientific programme is nearing completion, with notifications sent to oral and posters submitters.

Detailed Programme

Programme overview

Sunday, October 6

9:30-15:30 - Short Courses

• Introduction to practical supercritical fluid chromatography
• Towards a better understanding of performing good practical reversed phase HPLC
• Introduction to multi-dimensional chromatography
• GC & GC-MS Sustainability & Health Check

17:00-17:30 - Opening Ceremony

17:30-18:15 - Plenary: Navigating the Evolving Therapeutic Landscape with Advanced Analytical Technologies

• Presenter: Kelly Zhang (Genentech, United States)

18:15-19:00 - Plenary 2

19:00-19:30 - Awards

19:30-21:00 - Welcome Reception

Monday, October 7

09:00 – 10:20 - Fundamentals 1 (Hall 1A)

• Characterization of solute-solvent interactions for neutral and ionized compounds in liquid chromatography systems by means of Abraham’s solvation parameter model
• Overcoming the modulation challenges in two-dimensional liquid chromatography
• Development of global machine learning models for understanding retention mechanism and predicting retention time in supercritical fluid chromatography/mass spectrometry
• Insights into the solute-adsorbent interactions in HILIC

09:00 – 10:20 - Environmental (Hall 1B)

• The art of separating biosurfactants produced by Bacillus humi
• Analysis of (micro-)plastic-associated chemicals released into marine environments by comprehensive multidimensional gas chromatography-mass spectrometry
• Separation, detection and speciation of five chelating agents in complex radioactive effluents with high-resolution Orbitrap mass spectrometry
• Molecularly imprinting-based solid phase extraction for the extraction of target steroid hormones and their transformation products present in wastewater samples
• The feasibility of combining gas chromatography/comprehensive two-dimensional gas chromatography and mass spectrometry for the determination of poly- & perfluorinated hydrocarbons in environmental applications

09:00 – 10:00 - Omics (Hall 1C)

• Liquid and Supercritical Chromatography Coupled to Multimodal Tandem Mass Spectrometry in Metabolomics
• Mitigating artifact formation in high-temperature LC-MS for bottom-up proteomics and quality control of protein biopharmaceuticals
• Optimized UHPSFC-HRMS/MS workflow for molecular networking to explore the specialized metabolism of Trichoderma reesei
• Analyte identification in untargeted analysis. Chromatography matters.

11:00 – 12:00 - Chromatographic modelling (Hall 1A)

• Development of a CEX platform method for monoclonal antibodies following ICHQ14 and DoE
• Exploring the utility of complementary incomplete separations in liquid chromatography
• Unlocking Objective Numerical Evaluation of Data Analysis Strategies: A Novel Platform to Generate Highly Realistic LC×LC and GC×GC Data

11:00 – 11:30 - Chirality (Hall 1B)

• Chiral stationary phases for isomer separations in bioanalytical and biopharmaceutical applications
• Unconventional van Deemter curves in chiral chromatography
• Exploiting the inherent chirality of cellulose: HPLC for enantiomeric separation on non-conventional cellulose derivatives as chiral stationary phases
• Flavanone diastereomeric excesses in bitter orange (Citrus aurantium L.) measured with SFC-SFC-MS in multiple heart-cutting mode

11:00 – 12:30 - Purification (Hall 1C)

• Vacuum-Assisted Headspace Microextraction: Fostering Innovation
• Multicolumn countercurrent chromatography combined with ethanol for the green purification of Crocin-I extracted from saffron
• Improvement in downstream purification process efficiency by removing bottleneck unit operations
• The strength of peak recycling in sustainable and challenging purification of natural compounds

13:00 – 14:00 - Tutorial: Building ‘Green’ into your Chromatographic Methods

14:00 – 15:00 - Tutorial: T2 Harnessing the power of Data Analytics: your analytical journey from complexity to clarity

13:30 – 15:00 - Posters 1

15:00 – 16:30 - Novel instrumentation (Hall 1A)

• Sustainable 2LabsToGo
• Immobilized Artificial Membrane Liquid Chromatography vs Liposome Electrokinetic Chromatography: suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of drugs’ passage through the respiratory mucosa.
• Optimization and the use of 2-dimensional chromatography for on-line mRNA digestion and sequencing
• Online LCxSFC: how to make a successful coupling?

15:00 – 16:30 - Forensics (Hall 1B)

• Separating the guilty from the innocent – The use of chromatography in forensic science
• Applying the Green and Simple Moka-Pot Extraction to detect Performance Enhancing Drugs Via HPLC-MS/MS In Dietary Supplements.
• Evaluation of Supramolecular Deep Eutectic Solvents, Cyclodextrin- and Cyclofructan- based Chiral Selectors for the Enantioseparation of Novel Psychoactive Substances in CE and HPLC - The Potential of the Use of Deep Eutectic Solvents and Amino Acid-Based Ionic Liquids as Additives
• Characterisation of a seized illicit drug sample by high resolution liquid chromatography mass spectrometry

15:00 – 16:30 - Petroleum, Plastics and Biopolymers - A Tribute to Keith Bartle (Hall 1C)

• New Fuels and New Challenges – Release the Hyphens!
• Integrated analysis of plastic additives in medical devices with online SFE-SFC-MS
• Aromatic-selective size exclusion chromatography (ASSEC): A swift solution for complex petroleum characterization
• Going big: HRMS-hyphenated separations unleash the analysis of complex proteoforms over 100 kDa

17:30 – 18:30 - HPLC Tube Sepsci slam

18:30 – 19:30 - LCGC Awards

Tuesday, October 8

08:30 – 10:20 - Oligonucleotides (Hall 1A)

• Separation of next generation therapeutic oligonucleotides (ASO & siRNA) using ion-pair chromatography based on fundamental separation science
• From LC-UV to MS-based methodology for the analysis of siRNA
• Separation method development of oligonucleotides on mixed-mode column and by 2D-LC/UV/MS
• Development of Multiple Heartcutting Two-Dimensional Liquid Chromatography with Ion-Pairing Reversed-Phase and Hydrophilic Interaction Chromatography for Characterization of Impurities in Therapeutic Oligonucleotides
• Dispelling the myths of Oligonucleotide chromatography

08:30 – 10:20 - Bioanalysis (Hall 1B)

• Large molecule bioanalysis using LC-MS, method optimization considerations
• The Use of High Throughput (HT) Vacuum Jacketed UHPLC for the Investigation of the Metabolism, Toxicokinetics and “Omic” effects of Methapyrilene in the Rat
• A review of analytical parameters in 'rapid' liquid chromatographic methods for bioanalysis: Can we do better?
• Bottom-up Protein LC-MS: Can buffer choice make or break a rapid tryptic digestion assay?
• SMART SAMPLERS FOR SIMPLIFIED LC-MS/MS ANALYSIS OF PROTEIN BIOMARKERS

08:30 – 10:20 - Small molecules (Hall 1C)

• The analysis of small polar molecules by HPLC
• Trace analysis of impurities in Phosphoric Acid purification process using Ion Chromatography
• Characterization of Hydrophilic Interaction Liquid Chromatography (HILIC) Columns using fluorouridine derivatives
• Beyond conventional: evaluating the potential of HILIC for collagen peptide mapping analysis
• Insights into retention behavior and selectivity in HILIC through quantitative retention mechanism assessment

11:00 – 12:30 - Big Data Modelling (Hall 1A)

• Harnessing Cloud Computing for Breakthroughs in Chromatography and Analytical Chemistry
• Exploration of critical parameters for the retention of molecules in achiral Supercritical Fluid Chromatography with the support of Data Science
• Automated Method Development in Liquid Chromatography for Polymer Analysis
• Automating Method Development for 1D and 2D-LC of Biopharmaceuticals

11:00 – 12:30 - Emerging Column Technology 1 (Hall 1B)

• Vacuum Jacketed Columns: Principles, Laboratory Practices, and More
• SPP 3,5-Dinitrobenzamido-silica: exploiting the key strengths of a simple but effective LC Stationary Phase
• Investigating Novel GC Column Chemistries for Improved Performance, Sensitivity and Data Quality and Accuracy
• New Monodisperse fully porous particles (MFPP) for HPLC analysis

11:00 – 11:30 - Drugs of Abuse (Hall 1C)

• A Holistic Approach to the Analysis of Novel Psychoactive Substances

13:00 – 14:00 - Tutorial: Applied Troubleshooting for Gas Chromatography

13:30 – 15:00 - Posters 2

14:00 – 15:00 - Tutorial: In-silico retention modelling for chromatographic separations

15:00 – 16:30 - Miniaturisation (Hall 1A)

• To Infinity (1290) and Beyond – Miniaturising HPLC out of the lab
• ChromaSkin and Permeapad®: innovative tools for investigating the passage through the skin of chemicals.
• Portable ion chromatography-based platform for robust in-field analysis of nitrogen containing anions and cations in environmental and industrial waters
• Rapid and Reliable Nitrite Content Analysis in Pharmaceutical Excipients with the ACQUITYTM QDaTM II Mass Detector

15:00 – 16:30 - Clinical (Hall 1B)

• Quantitative Retention-Chemical Structure Relationship (QSRR) in the study of biological activity
• HILIC/MS Quantitation of Low-Abundant Phospholipids and Sphingolipids in Human Plasma and Serum: Dysregulation in Pancreatic Cancer
• Body volatolome, from sampling to understanding: a promising solution for health monitoring
• Machine Guided Optimization of Organic Semi-Conductor Films for Light Activated Antimicrobials and Antiviral Surfaces

15:00 – 16:10 - Separation Technology of the Future (Hall 1C)

• The fantastic world of gold colloids and other things small
• The Power of Vacuum UV Detection in Gas Chromatography in the Pharmaceutical Industry
• In-Column Derivatisation’ (ICD): A modernised approach to selective post-column assays

17:10 – 18:10 - Plenary: Sustainable Separations for a Circular Economy through Green Chemistry

• Presenter: John Warner (Technology Greenhouse, LLC, United States)

Wednesday, October 9

08:10 – 10:00 - Sustainability 1 (Hall 1A)

• Building a Global Culture of Sustainability in Science
• Going For Green In Chromatographic Analysis – A Perspective From Within The Pharmaceutical Industry
• Putting a number on chromatography sustainability within the pharmaceutical industry: Analytical Method Greenness Score (AMGS)
• Laboratory Sustainability - the mediocre present and the positive future
• Removing chromatography bottlenecks using convolutional neural network in automated purification

08:10 – 10:00 - BMSS - Mass Spectrometry in Separation Science (Hall 1B)

• Analysis of Bicycles- Novel Medium Molecules
• Exploring the potential of Differential Mobility Spectrometry (DMS) as a pre-separation technique, preceding the MS/MS detection system for the simultaneous detection of triazole derivative metabolites (TDMs) in animal feed samples
• The Fastest Chromatography is No Chromatography at All: Introducing Selected Ion Flow Tube Mass Spectrometry (SIFT-MS)
• Unprecedented Reproducibility Achieved in the First High-Resolution Ion Mobility Inter-lab Lipidomic Study of Human Plasma
• Paper Arrow Mass Spectrometry: A Seamless Integration of Modified Paper Chromatography with Paper Spray for an Exemplary Clinical Scenario of Paracetamol Overdose

08:10 – 10:00 - Water analysis (Hall 1C)

• Anyone for a Cocktail? Applying analytical techniques to investigate the occurrence of chemicals of emerging concern in the aquatic environment.
• Portable and field-deployable liquid chromatography – mass spectrometry system for haloacetic acids analysis in drinking water
• Development of a column switching for direct online enrichment and separation of polar and nonpolar analytes from aqueous matrices
• Enhanced Non-Targeted Analysis Efficiency and Identification Confidence for Polyfluorinated Alkyl Substances Using Liquid Chromatography and Cyclic Ion Mobility Mass Spectrometry

10:40 – 12:10 - Untargeted Analysis 1 (Hall 1A)

• Chromatography in Metabolomics - Progress in High Throughput Metabotyping by LC-MS
• Untargeted analysis of antioxidant degradation products utilising LC-HRMS and GC-MS
• Building of a high-resolution mass spectral library by LC-Orbitrap: chemical exposure agents
• The Role of Semi-Quantitative Approach in Identifying Fragrance Content in Perfumes

10:40 – 12:10 - Food 1 (Hall 1B)

• The Flavors of Chromatography
• Novel Stationary Phase for the Separation of all Classes of Carbohydrates
• Comparison of state-of-the-art analytical platforms for the analysis of growth promotors in livestock biofluids
• Analysis of volatiles in food – untargeted analysis using GERSTEL Dynamic Headspace (DHS) and the LECO Pegasus® BT 4D TOF

10:40 – 12:10 - Emerging Column Technology 2 (Hall 1C)

• Chromatographic column orderliness achieved by bottom-up precision engineering
• 3D printed stationary phases for the downstream processing of therapeutic antibodies
• Crosslinking Effects on the Separation of Anions with Novel Hybrid Anion Exchangers for Ion Chromatography
• Orthogonal separation in comprehensive two-dimensional liquid chromatography (LC × LC) using Sil‑Lys‑2C18 as stationary phase in both dimensions

12:40 – 13:40 - Tutorial - Practical LC-MS; If a little bit works, then a little bit less probably works better!

13:10 – 14:40 - Posters 3

3:40 – 14:40 - Tutorial - Experience the power of Free, Web-based Computer Modeling Tools to Simulate Gas Chromatographic Separations. Having a GC in your laptop

14:40 – 16:10 - Flash Posters

14:40 – 16:10 - Polymer Analysis (Hall 1A)

• LC METHODS TO STUDY POLYMER STRUCTURE
• Characterisation of biodegradable polymers and photodegradation products by pyrolysis multidimensional gas chromatography-mass spectrometry (Py-GCxGC-MS)
• Boosting the separation efficiency of Hydrodynamic Chromatography by shaping the cross-channel section
• Employing capillary electrophoresis where chromatography fails: assessment of the charge heterogeneity of polymeric nanoparticles

14:40 – 16:10 - Sustainability 2 (Hall 1B)

• SFC-MS coupling: Current state and advances
• Eco-Optimized HPLC Columns: Navigating Toward a Greener Analytical Future
• Improving sustainability through modernisation of LC methods
• How transparency and awareness can make a change in your lab’s sustainability journey

14:40 – 16:10 - Novel Pharmaceutical Modalities (Hall 1C)

• Utilizing the on/off retention model of proteins to enhance selectivity in liquid chromatography
• High-throughput HPLC analysis of lipids and related impurities with ELSD and MS detection for the quality control before and after the LNP formulation
• Addressing the analytical gap in the analysis of non-biological complex drugs - a case study for the comprehensive chemical analysis of bituminosulfonate
• Expanding the mRNA Characterization Toolbox using Size-exclusion Chromatography, Multi-angle Light Scattering Detection and Mass Photometry

16:50 – 17:25 - Plenary 4

16:50 – 17:25 - Plenary: Prioritizing and elucidating the structure of toxic chemicals based on complementary empirical analytical information from LC/HRMS

• Presenter: Anneli Kruve (University of Stockholm, Sweden)

Wednesday, October 10

08:30 – 10:00 - Fundamentals 2 (Hall 1A)

• Unraveling mass transfer phenomena of biomolecules in liquid chromatography
• Reimagining the Cm and Cs-terms of van Deemter’s equation
• Optimal thermal control for temperature responsive LC columns
• Optimizing gradient profiles for liquid chromatography: a comparison of optimization algorithms and the influence of the chromatographic response function

08:30 – 10:00 - Untargeted Analysis 2 (Hall 1B)

• The Power of Separation Techniques in Metabolomics
• A click inverse electron-demand Diels-Alder reaction for assigning the carbon-carbon double bond regiochemistry in untargeted lipidomics
• Modern chromatography for non-target screening applications
• Is GC×GC the ultimate tool for untargeted analysis of volatile compounds?

08:30 – 10:00 - Food 2 (Hall 1C)

• Challenges in chromatographic analyses of phytonutrients in food samples
• Practices for improving the quantitative analysis of PFAS
• Advantages of SFC-MS over LC-MS in food safety analysis
• Using head-space SPME and Hi-Sorb extraction techniques gas chromatography mass spectrometry to assess the volatiles in mature Cheddar cheese

10:40 – 11:25 - Plenary: Unraveling the Threads: Exploring Degradation Pathways of Materials in Art

• Presenter: Maarten van Bommel (University of Amsterdam, Netherlands)

11:25 – 12:10 - Plenary: Implementation of Liquid-Based Separation Science on Future Astrobiology Missions

• Presenter: Peter Willis (NASA, United States)

13:30 – 14:00 - Awards (Poster | Slam | Tube)

14:00 – 14:30 - Plenary: ISC 2026

14:30 – 15:00 - Plenary: ISC 2028

15:00 – 15:30 - Farewell

Plenary Speakers

John Warner (Father of the principles of Green Chemistry)

Maarten van Bommel (Conservation Science, Uni Amsterdam)

Anneli Kruve (Assoc Prof, Uni. Stockholm)

Kelly Zhang (Distinguished Scientist, Genentech)

Michal Holčapek (Analytical Chemistry, Uni Padubice)

Ana M. García-Campaña (Analytical Chemistry, Uni Granada)

Professor Alastair Lewis (Atmospheric Chemistry, University of York)

Dr. Peter A. Willis (JPL Principal Member of the Technical Staff, Supervisor of the Chemical Analysis and Life Detection Group, NASA)

Submissions

Oral submissions are now closed, however Poster submissions will be accepted until 1 August 2024.

ISC 2024 Submission Site

All submissions should have a chromatography bearing and be covered by one of the following topics:

• Fundamentals
• Forensics
• Automation
• Petrochemicals
• Industry 4.0
• Miniturisation
• Environmental
• Chirality
• Clinical
• Emerging column technology
• Novel pharmaceutical modalities
• Automation
• Omics
• Hyphenated Techniques
• Drugs of abuse
• Spatial separations
• Biopharma
• Chromatographic modelling
• Oligonucleotides
• Food
• Sustainability
• Untargeted Analysis
• Polymer Analysis
• Purification

The following techniques will also be covered:

• Sample preparation
• Gas Chromatography
• HPLC
• Electrophoretic techniques
• Planar chromatography
• Supercritical fluid chromatography

Registration

Registration is now open!

Book Here

Early Bird – Up to 31 July 2024

Industry: £845 / 985euro*
Academic: £695 / 810euro*
Student: £360 / 420euro*
Accompanying Person: £260 / 303euro*
2 Day Ticket: £500 / 580euro*
Short Course: £200 / 233euro*
Gala Dinner: £90 / 105euro*

Standard – From 1 August 2024

Industry: £945 / 1102euro*
Academic: £795 / 927euro*
Student: £395 / 460euro*
Accompanying Person: £275 / 321euro*
2 Day Ticket: £500 / 580euro*
Short Course: £200 / 233euro*
Gala Dinner: £90 / 105euro*

* Approximate Euro figure shown. Euro amount payable is calcuated based on daily exchange rate at check out on registration site.

Location

Liverpool

Liverpool was at the heart of the industrial revolution and has been a centre of invention and innovation ever since. Railways, including model railways, transatlantic steamships, municipal trams, and electric trains were all pioneered in Liverpool as modes of mass transit. The first British Nobel Prize was awarded in 1902 to Ronald Ross, professor at the School of Tropical Medicine – the first school of its kind in the world. Closer to the theme of the symposium, Richard Laurence Millington Synge, one of only two chromatographers to have been awarded a Nobel prize, was born in Liverpool. The area around Liverpool has seen many developments both from the formation of silica valley, with companies such as Hypersil and Phase Separations both developing and manufacturing HPLC packing material in the locality to more recent activities at the University of Liverpool which have seen a range of innovating approaches to the applications of separation science.

Conference Venue

The conference venue is on the banks of Liverpool’s world heritage waterfront, gateway to one of the world’s most famous ports. It is part of Europe’s only purpose-built interconnected arena, convention and exhibition centre situated alongside on-site hotels. The ultra-modern surroundings will ensure maximum comfort and also fully integrated technology to ensure that no lecture is missed. It is truly an awe-inspiring place where the imagination can truly be allowed to have free reign.

ISC 2024 takes place at:

ACC Liverpool

Kings Dock

Liverpool Waterfront

Liverpool

Merseyside L3 4FP

United Kingdom

ISC 2024 / Wynne McCoy: ACC Liverpool.