In our recent blog on <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5662">selecting software for targeted MS quantitation</a>, we outlined five key criteria labs should evaluate: simplified workflows, flexible access, scalability, regulatory readiness, and MS-native capabilities. These principles increasingly define how labs operate today, where chromatography and mass spectrometry often work hand in hand to deliver confident results— and they are foundational to <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon 7.4 software</a>.This release reflects how analytical workflows are changing. Workflows are no longer confined to individual techniques or isolated systems. From development through QA/QC and regulated use, laboratories need consistency in how data is created, processed, reviewed, and governed across instruments, users, and sites.Chromeleon 7.4 software supports this evolution by bringing chromatography and mass spectrometry together within a single enterprise-ready environment, helping reduce variability, strengthen compliance, and scale operations without increasing complexity.<h3>1. Simplified data and workflow management</h3>Quantitative workflows can generate significant volumes of data, but challenges often begin earlier, during method development. In many labs, moving from exploratory method development into validated, routine analysis still requires rebuilding methods, switching systems, or reconfiguring workflows. This adds time, variability and risk.Chromeleon 7.4 software helps eliminate these barriers by supporting the entire analytical lifecycle — from method creation through routine acquisition, processing, and reporting, within a single, cohesive environment. This continuity reduces setup time, preserves consistency as methods evolve, and supports both development and high-throughput analysis.Enhanced visualization tools support confident decision-making. The fragment visualization pane displays MS² and MS³ fragments alongside chromatographic traces, while integrated isotopic pattern simulation enables rapid confirmation of expected results without relying on external tools.Together, these capabilities reduce workflow reconfiguration, enabling laboratories to minimize variability and reduce the risk of errors introduced during method transfer or routine deployment.<blockquote>See this in practice – <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5321">Extending the dynamic range of GLP-1 quantitation using the Thermo Scientific Stellar MS and Chromeleon software</a></blockquote><h3>2. Connected, controlled, and collaborative</h3>Today’s laboratories rarely operate under one roof. Whether across departments or global sites, teams need to collaborate while maintaining data integrity and compliance.With centralized data access and flexible remote control, Chromeleon 7.4 software enables secure collaboration. The Business Continuity Repository enhances existing network failure protection by replicating key files locally, allowing uninterrupted operation even during server outages. Analysts stay productive, and data remains protected.This flexibility supports hybrid work models, multi-site operations, and continuous productivity — all without compromising data control.<blockquote>Learn more in our recent webinar – <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5232">Targeted MS quantitation – controlled and accessed from anywhere</a></blockquote><h3>3. Designed for modern, scalable workflows</h3>As analytical workloads grow and diversify, software must scale seamlessly across instruments, users, and sites.Chromeleon 7.4 software integrates advanced MS workflows into a single platform that also supports multiple separation techniques including LC, GC, IC and CE. This allows laboratories to standardize how data is acquired, processed, reviewed, and managed.Standardizing workflows within one platform reduces reliance on disconnected systems, supporting operational consistency and simplifying oversight for QA and IT teams. Centralized administration supports coordinated updates and uptime, while open integration capabilities enable connection to broader digital ecosystems such as LIMS.<h3>4. Designed with compliance in mind</h3>In regulated environments, compliance can’t be an afterthought — it must be built into the foundation. This Chromeleon release strengthens its already robust compliance framework with features that promote transparency, integrity, and control throughout the analytical lifecycle.Built-in support for system suitability testing and controlled processing helps ensure consistent method performance throughout routine use. Enhanced audit trail policies improve visibility into data changes, while processing visibility controls ensure results are viewable only once saved — reinforcing traceability and data integrity.By embedding quality and control into analytical workflows, Chromeleon software reinforces transparency and confidence across the data lifecycle. These capabilities support alignment with 21 CFR Part 11, EU Annex 11, and GxP guidelines — without relying on external tools or manual workarounds.<blockquote>Discover how – <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5583">Safeguard dataset quality in LC-MS analysis with system suitability testing and intelligent run control</a></blockquote><h3>5. Enterprise-ready platform</h3>As laboratories expand across departments and global sites, consistency becomes as important as capability.Chromeleon software is designed to support enterprise operations through centralized administration, standardized governance across chromatography and MS workflows, data continuity protection via the Business Continuity Repository, and integration readiness with laboratory informatics ecosystems such as LIMS.By consolidating workflows within a single CDS environment, laboratories can coordinate updates, maintain operational consistency, and support growing analytical demands — without relying on disconnected systems.<h3>Why now?</h3>Laboratories are under increasing pressure to manage growing data volumes, support multiple techniques, and meet rising compliance expectations — often with limited resources.As workflows expand across teams and sites, laboratories need software that is reliable, scalable, and flexible enough to support both routine and advanced analysis without adding operational complexity.<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon software</a> helps organizations meet these demands by providing a single, enterprise-ready platform for acquiring, managing, reviewing, and trusting analytical data — across chromatography and mass spectrometry alike.<ul><li>To explore how these capabilities come together in real-world workflows, take a look at our recent webinars and experience <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/chromatography/chromatography-data-systems-cds/cds-software-built-mass-spectrometry.html">Chromeleon 7.4 software</a> in action. &nbsp;</li><li>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#Chromeleon #MS #Chromatography #Compliance</li></ul>

Purpose-Built Software for Quantitation Workflows – Solving Data, Compliance, and Collaboration Challenges

Rotary evaporation has long been a staple in laboratories for removing solvents from samples efficiently. However, as technology advances and the demand for higher throughput and more efficient processes increases, alternative methods are becoming more attractive. One such alternative is <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=338">Organomation's S-EVAP evaporators</a>. For laboratories interested in processing several samples simultaneously, the S-EVAP offers significant advantages over multiple rotary evaporators.<h3>Understanding Rotary Evaporation</h3>Rotary evaporation is a technique widely used in chemical and biochemical labs to remove solvents from samples by applying heat and reducing pressure to induce evaporation. The process involves a rotating flask, which increases the surface area for evaporation, making it efficient for solvent removal. Despite its effectiveness, rotary evaporation has limitations, especially when dealing with high-throughput requirements or multiple samples simultaneously.<h3>Criteria for Choosing an Alternative</h3>When selecting an alternative to rotary evaporation, several factors need to be considered:<ul><li>Efficiency: How quickly and effectively can the alternative remove solvents?</li><li>Cost-effectiveness: What is the initial investment and operating cost?</li><li>Ease of use: How user-friendly is the equipment?</li><li>Applicability: Can the alternative handle a variety of solvents and sample types?</li><li>Scalability: Is the method suitable for processing multiple samples simultaneously?</li></ul><h3>Alternatives to Rotary Evaporation</h3><h4>1. Organomation's S-EVAP Evaporators</h4>Organomation's S-EVAP evaporators, available in<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1904"> Kuderna-Danish (KD)</a> and<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1905"> round-bottom (RB)</a> flask models, are designed for laboratories requiring high throughput and efficient solvent removal.&nbsp;<ul><li>S-EVAP KD is available in 8 or 10 position models and can handle sample sizes up to 500 mL</li><li>S-EVAP RB models also offer 8 or 10 positions with capacities up to 250 mL per sample</li></ul>The S-EVAP system is tailored for general evaporation and concentration of analytical or environmental samples using various glassware configurations to meet specific method requirements under controlled and reproducible conditions.This system features rapid solvent evaporation with solvent vapor recovery, achieving solvent recoveries exceeding 96% by volume under ideal conditions.&nbsp;It can operate with cold tap water or a recirculating chiller system, ensuring efficient cooling. The digital controlled water bath provides even and uniform heating without scorching the final samples.&nbsp;The parallel water manifold system ensures even cooling water distribution to each condenser, while the rotary water manifold allows unlimited instrument rotation for easy front loading without condenser tubing entanglement.<h5>Advantages of S-EVAP Over Rotary Evaporation:</h5><ul><li>Higher Throughput: The S-EVAP can process multiple samples simultaneously, significantly increasing throughput compared to using several rotary evaporators.</li><li>Cost-Effectiveness: Although the initial investment may be higher than a single rotary evaporator, the S-EVAP's ability to handle multiple samples at once reduces the need for additional equipment. Lower maintenance costs and reduced need for additional space and infrastructure.</li><li>Ease of Use: User-friendly design with straightforward controls and easy maintenance. Reduced handling time compared to managing multiple rotary evaporators, allowing technicians to focus on other tasks.</li><li>Consistency and Precision: Uniform evaporation conditions ensure consistent results across all samples. Precise control over temperature allows for tailored evaporation conditions for different sample types.</li><li>Space Efficiency: A single S-EVAP unit occupies less space compared to multiple rotary evaporators, making it ideal for labs with limited bench space.</li></ul><h5>Integration in EPA Method 1699</h5>Rotary Evaporator Usage:<ul><li>Initial Solvent Reduction: Rotary evaporators are used first to remove bulk solvent from the sample extract. This step efficiently reduces the volume of the extract to a manageable level under reduced pressure, ensuring that the majority of the solvent is removed without significant loss of analytes.</li><li>Controlled Conditions: The rotary evaporator's ability to control temperature and vacuum precisely helps in handling large initial volumes and reducing them quickly.</li></ul>S-EVAP Evaporator Usage:<ul><li>Further Concentration: After the rotary evaporation step, the concentrated extract is transferred to the S-EVAP system. The S-EVAP evaporators, including the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1904">S-EVAP-KD</a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1905">S-EVAP-RB</a> models, are designed to handle smaller volumes and provide a final concentration of the sample.</li><li>Solvent Recovery: The S-EVAP systems offer efficient solvent recovery, with the S-EVAP-RB capable of achieving solvent recoveries exceeding 96% by volume under ideal conditions. This high recovery rate is crucial for environmental and analytical labs that aim to minimize solvent waste and ensure consistent results.</li><li>Even Heating and Cooling: The S-EVAP-RB features a digital controlled water bath for uniform heating, preventing scalding of the final samples. Additionally, the parallel water manifold system ensures even cooling to each condenser, enhancing the efficiency and reproducibility of the evaporation process.</li></ul>Benefits of Tandem Use<ul><li>Enhanced Efficiency: Using both systems in tandem allows for the initial large volume reduction by the rotary evaporator, followed by precise final concentration using the S-EVAP. This combination maximizes throughput and ensures high-quality results.</li><li>Cost and Space Efficiency: The rotary evaporator handles the bulk of the solvent reduction, reducing the strain on the S-EVAP system. This distribution of workload helps in maintaining the equipment and optimizing laboratory space.</li><li>Method Compliance: Following this tandem approach ensures compliance with EPA Method 1699, which outlines specific procedures for pesticide analysis in various environmental samples.</li></ul>Organomation's S-EVAP evaporators, when used in conjunction with rotary evaporators, provide an efficient and reliable solution for laboratories performing high-throughput solvent evaporation tasks, such as those required by EPA Method 1699. This tandem use ensures precise control over the evaporation process, high solvent recovery rates, and consistent sample preparation, making it an ideal approach for environmental and analytical laboratories.<h4>2. Buchi's Syncore Evaporators</h4>Buchi's Syncore evaporators are advanced evaporation systems designed to provide high throughput and efficiency. They use parallel evaporation technology, allowing simultaneous processing of multiple samples under controlled conditions.<ul><li>Applications: Drug discovery, natural product extraction and chemical synthesis</li><li>Advantages: High efficiency with parallel evaporation capabilities, advanced safety features and precise control over evaporation parameters</li><li>Limitations: Potential cost considerations and specific application limitations</li></ul><a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/s-evap-rb-vs-buchi-syncore-download">Download our S-EVAP-RB vs Buchi Syncore comparison with pricing!</a><h4>3. Freeze Drying (Lyophilization)</h4>Freeze drying, also known as lyophilization, is a dehydration process used to preserve perishable materials or make them more convenient for transport. The process involves three main stages: freezing, primary drying (sublimation), and secondary drying (desorption).<ul><li>Applications: Pharmaceuticals, food industry, biological samples.</li><li>Advantages: Long-term stability of dried products.</li><li>Limitations: High cost and time-consuming process.</li></ul>For a more in-depth review, please visit our piece on <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/types-of-laboratory-evaporators">Types of Laboratory Evaporators</a>.<h4>4. Centrifugal Evaporation</h4>Centrifugal evaporation is a technique used to remove solvents from samples by combining centrifugal force, vacuum, and heat. This method is particularly effective for drying samples rapidly and efficiently, making it ideal for high-throughput laboratories.<ul><li>Applications: Used for concentrating and drying biological samples, drug formulations, and other compounds that require gentle handling. Ideal for processing DNA, RNA, proteins, and other sensitive biomolecules.</li><li>Advantages: The combination of centrifugal force and vacuum significantly speeds up the evaporation process compared to traditional methods. Multiple samples can be processed simultaneously, making it suitable for high-volume laboratories.</li></ul>Limitations:<ul><li>Equipment Cost: High-quality centrifugal evaporators can be expensive to purchase and maintain.</li><li>Limited Sample Types: Not all sample types are suitable for centrifugal evaporation, particularly those that require very specific temperature or pressure conditions.</li><li>Technical Expertise: Requires trained personnel to operate the equipment and optimize conditions for different sample types.</li></ul><h4>5. Vacuum Distillation</h4>Vacuum distillation is a technique used to separate mixtures of liquids by utilizing reduced pressure, which lowers the boiling points of the components. This method is particularly useful for separating heat-sensitive compounds that might decompose at higher temperatures.<ul><li>Applications: Used to purify reaction products and separate mixtures in organic synthesis. Essential for refining crude oil into various fractions, such as gasoline, diesel, and lubricants.</li><li>Advantages: Achieves high levels of purity by effectively separating components based on their boiling points. Reduces the risk of thermal decomposition by operating at lower temperatures. Applicable to a wide range of substances, including complex mixtures and heat-sensitive materials.</li></ul>Limitations:<ul><li>Complex Setup: Requires specialized equipment and careful control of vacuum and temperature conditions.</li><li>High Cost: Initial investment and maintenance costs can be high.</li><li>Technical Skill: Operators need to be skilled in managing the distillation process to achieve optimal results.</li></ul><h4>6. Spray Drying</h4>Spray drying is a process used to convert liquid materials into dry powders by rapidly drying them with a hot gas. This technique is widely used in the food, pharmaceutical, and chemical industries for creating stable, shelf-stable powders.<ul><li>Applications: Used to produce powdered milk, coffee, eggs, and flavors. Employed in the production of powdered drugs and formulations.</li><li>Advantages: Efficiently converts liquids into dry powders in a short time. Allows precise control over the size and distribution of the powder particles.</li></ul>Limitations:<ul><li>High Energy Consumption: Requires significant energy to heat the drying gas.</li><li>Thermal Degradation: High temperatures can cause thermal degradation of sensitive compounds.</li><li>Complexity: Requires careful control of operating conditions to achieve desired product characteristics.</li></ul><h4>7. Simple Distillation</h4>Simple distillation is a basic method used to separate liquids with significantly different boiling points. It involves heating the mixture to vaporize the more volatile component, which is then condensed and collected.<ul><li>Applications: Used to purify solvents, water, and other liquids by removing impurities. Ideal for separating simple mixtures of two components with different boiling points.</li><li>Advantages: Easy to set up and operate with minimal equipment. Low initial investment and operating costs. Effective for separating mixtures with large differences in boiling points.</li></ul>Limitations:<ul><li>Limited Precision: Not suitable for separating complex mixtures or components with close boiling points.</li><li>Scalability Issues: Less efficient for large-scale industrial processes.</li><li>Thermal Degradation: Higher temperatures can cause degradation of heat-sensitive components.</li></ul><h4>8. Microwave-Assisted Evaporation</h4>Microwave-assisted evaporation is a technique that uses microwave energy to heat and evaporate solvents from samples. This method is efficient and rapid, making it suitable for various laboratory applications.<ul><li>Applications: Used to speed up reactions and solvent removal in organic synthesis. Employed for drying drug formulations and preparing samples for analysis.</li><li>Advantages: Microwaves heat samples quickly and uniformly, reducing evaporation time.</li></ul>Limitations:<ul><li>Equipment Cost: Microwave evaporators can be expensive to purchase and maintain.</li><li>Sample Compatibility: Not all samples are suitable for microwave heating, particularly those with low dielectric properties.</li><li>Safety Concerns: Requires careful handling to avoid overheating and potential hazards.</li></ul><h3>Conclusion</h3>For laboratories that need to process several samples simultaneously, Organomation's S-EVAP evaporators present a compelling alternative to rotary evaporation. By offering higher throughput, cost-effectiveness, ease of use, and space efficiency, the S-EVAP can streamline laboratory workflows and improve overall productivity. As technology continues to evolve, staying informed about the latest advancements in evaporation methods will ensure that labs can maintain optimal performance and efficiency.

Exploring Alternatives to Rotary Evaporation in Modern Laboratories

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 27th July 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies and Thermo Fisher Scientific, poster by MDCW / University of Washington and brochure by Shimadzu!<h3>1. Agilent Technologies: Routine Trace‑Level Analysis of m‑Xylene in High‑Purity p‑Xylene</h3>Using the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B">Agilent 8890B GC system</a><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_trace_analysis_m_xylene_high_purity_p_xylene_5994_9329en_agilent_508bcfb48c.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>The Agilent 8890B GC system builds on the exceptional performance of the Agilent 8890A GC, with the addition of many features designed to enhance the user experience for both new and expert‑level operators. This application note explores several use cases of these features applied to a challenging GC purity method—quantifying trace‑level m‑xylene (MX) in p‑xylene (PM). This separation requires careful balancing of optimized chromatographic parameters— speed, resolution, and sensitivity. Leveraging Agilent GC Assist features, including early maintenance feedback (EMF) counters and automated peak evaluation capabilities integrated into the 8890B GC, helps maximize method robustness and instrument uptime.&nbsp;Though conceptually simple, separating and measuring small quantities of m‑xylene in p‑xylene is a challenge that requires precise instrument control and the highest‑quality GC parts and consumables. As both compounds are positional isomers and have nearly identical boiling points, separation has historically been achieved using a long and highly polar column, such as a polyethylene glycol "wax" phase. ASTM D7504 recommends a wax column with dimensions 60&nbsp;m × 0.320 mm and 0.25 µm phase thickness. A 0.50 µm phase thickness can be used for increased resolution.1 The separation is validated with a p‑xylene standard containing approximately 1,000 ppm m‑xylene. Measuring m‑xylene at significantly lower concentrations requires an increase in resolution between MX and PX, which can be accomplished by increasing the phase thickness of the column at the cost of increased peak broadening. This broadening negatively impacts the limit of detection (LOD) and the limit of quantification (LOQ) for MX and must be offset by reducing the inner diameter of the column to resharpen the peak. This application note demonstrates the use of 0.200 mm and 0.100 mm id wax columns to yield optimized separations, presenting the associated benefits and limitations of both&nbsp;separations.<h4>Experimental</h4>An <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B">8890B GC</a> was configured with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7650A">Agilent 7650A automatic liquid sampler</a> (ALS), split/splitless (SSL) inlet, and flame ionization detector (FID). Two columns were used to explore two different separation speeds—a faster separation with less sample capacity using an Agilent J&amp;W DB‑WAX&nbsp;FF column, 20 m × 100 µm, 0.2 µm (p/n 127‑7023FF) and a higher‑resolution separation with more sample capacity using an Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=J%26W+HP%E2%80%91INNOWax">J&amp;W HP‑INNOWax</a> column, 50 m × 200 µm, 0.4 µm (p/n 19091N‑205I). Both methods used hydrogen carrier gas, and Agilent Gas Clean filters were used to remove moisture, hydrocarbons, and oxygen from the carrier gas and FID hydrogen. The FID air was filtered for moisture and hydrocarbons. The GC configuration and method details can be found in Tables 1 and 2, respectively.<h4>Results and discussion</h4>Establishing and ensuring the method’s long‑term stability requires protecting the column stationary phase by limiting the amount of oxygen in the system. While carrier gas contamination is typically the largest source of unwanted oxygen, the inlet septum can also contribute to oxygen ingress as successive syringe injections create a hole, necessitating regular changing. The Agilent portfolio of consumables and supplies has several solutions specifically designed to overcome these challenges. The Gas Clean purification system features a carrier gas filter that removes oxygen, moisture, and hydrocarbons and includes a color‑changing visual indicator of filter life, which can be monitored remotely by the 8890B GC using an optional optical sensor. Advanced Green septa are engineered for low bleed and extended durability, further enhanced by using a Blue Line autosampler syringe with a tapered needle to reduce physical coring of the septum. Regular maintenance of these parts maximizes instrument uptime. The 8890B GC has several features designed to warn when maintenance is approaching, assist when maintenance is required, and track when maintenance is completed.The 8890B GC features intelligent tracking of the ages of consumables using injection‑ and time‑based counters. These EMF counters feature two optional warning thresholds—"Service Warning" and "Service Due"—that are user‑configurable and function like the oil light on the dashboard of a vehicle, telling users of approaching maintenance. The EMF counters can be accessed directly through the GC touchscreen or through the GC Assist interface. Figure 1 shows an overview of the EMF counters for the front inlet, and Figure 2 presents the detailed history of septum maintenance, including a running tally of injections on the current septum. When performing maintenance on the 8890B GC using the guided maintenance process on the touch screen or GC Assist interface, the EMF counters are automatically reset at the end of the procedure and can also be reset manually. For this application, the EMF counters and appropriate warning thresholds for the septum, liner, syringe, column, inlet gold seal, and carrier gas filter will be explored.<h4>Conclusion</h4>The Agilent 8890B GC system—powered by the highest‑quality Agilent columns and supplies—delivers a robust, sensitive solution for measuring trace‑level m‑xylene (MX) in p‑xylene (PX). The Agilent J&amp;W HP‑INNOWax column produced the highest‑resolution separation and the best retention time stability, with an S/N ratio of 98.5 for 50&nbsp;ppm MX. The narrower Agilent J&amp;W DB‑WAX FF column yielded a 40% faster run time at the cost of lower resolution and retention time stability, with an S/N ratio of 27.7 for 50&nbsp;ppm MX. The integrated Agilent GC Assist features, peak evaluation and early maintenance feedback (EMF) counters, provide intelligent, automated monitoring of system and separation health, maximizing instrument uptime and supporting long‑term success with routine trace analysis.<h3>2. MDCW / University of Washington: Developing 2D mzCompare for single GC×GC-TOFMS chromatograms: Substantial resolution enhancement in the context of statistical overlap theory</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_4_Wenjing_899f31a19e.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>Accurate identification of all detectable analyte components in a single comprehensive twodimensional (2D) gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS) chromatogram is a fundamental interest in the field. Herein, we developed a new algorithmic software approach called 2D mzCompare to generate accurate peak tables for GC×GCTOFMS. Extending from our original method for one-dimensional GC-MS data, the 2D mzCompare algorithm discovers selective mass channels (m/z) for each analyte to resolve overlapping peaks and improve analyte identification, leveraging the similarity in retention time and peak shape across m/z of the same analyte. The 2D mzCompare algorithm calculates the peak shape similarity between m/z at every modulation via lack-of-fit (LOF), followed by clustering and focusing steps, to generate a final peak table. To evaluate this software, we simulated realistic GC×GC-TOFMS data in the context of the statistical overlap theory (SOT), so the exact number and identities of analytes are known a priori. Utilizing an in-house mass spectrum library of similar compounds, GC×GC-TOFMS chromatograms were simulated with varying degrees of chromatographic saturation (𝛼2𝐷). First, we provide a new algorithmic approach, 2D mzCompare, to resolve overlapped analytes in GC×GCTOFMS data, and second, we validate the accuracy of the software performance using SOT.<h4>Conclusions and Future Work</h4>An extended algorithm, 2D mzCompare designed for intra-chromatogram comparison to enable rigorous analyte discovery and identification, was developed for GC×GC-TOFMS data. Within the context of SOT, 2D mzCompare increases separation resolution by computationally minimizing the 2D peak widths, enhancing 2D peak capacity and reducing the saturation factor. At low saturation factors (𝛼2𝐷= 0.01, 0.03, and 0.1), over 95% of the simulated components are found to be mathematically resolved singlets (pure analyte components) by 2D mzCompare, while approximately 62% were found at 𝛼2𝐷 = 1, exceeding predictions made by SOT. Using optimized 2D mzCompare parameters, improvements in 2Rs and 𝛼2𝐷 are about 12-fold, empirically validating SOT expectations. Furthermore, 2D mzCompare can be used as a preprocessing tool to determine or validate the “rank” (the number of analyte components) in overlapped regions of GC×GC-TOFMS chromatograms when combined with chemometric methods such as MCR-ALS or PARAFAC. Future studies will focus on applying the algorithm to real sample datasets.<h3>3. Shimadzu: Meet The World’s First Multi-Mode FID In <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GC-2060">Nexis GC-2060</a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/s_gc_f33_3f7f48eead.pdf">Full PDF for download</a></li></ul><h4>High Performance And Low Maintenance Multi-Mode FID&nbsp;</h4>The new FID-U (2.0) in the Nexis <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GC-2060">GC-2060</a> reengineers conventional FID to maximize uptime and efficiency. With new Air and O2 makeup gas options, you can streamline your gas supply – saving cylinder costs and lab space. Its capabilities can be further expanded with Shimadzu’s proprietary Jetanizer and Polyarc microreactors.<h4>Cylinder-Free FID Operation With Hy/Ox and Hy/Air Modes&nbsp;</h4>Routine operation with traditional FIDs is often costly and complex, requiring a three-gas setup: a He or N2 makeup gas combined with H2 and Air. The new FID simplifies your infrastructure by introducing Air and O2 as makeup gas alternatives, unlocking true cylinder-free operation.* This helps to reduce running cost and cut helium usage.<h4>Keep Your Bench Space As You Expand Your Analyte Coverage&nbsp;</h4>Seamlessly integrate Jetanizer and Polyarc microreactors to boost detector response for weak or undetectable compounds. The new FID delivers simpler quantitation and broader analysis capabilities with zero extra footprint.<h4>Jetanizer Mode (CO and CO2 Detection)&nbsp;</h4><ul><li>Converts CO and CO2 to CH4 for detection&nbsp;</li><li>Enabled by simply replacing the FID nozzle&nbsp;</li></ul><h4>Polyarc Mode (Single-Calibration Approach)&nbsp;</h4><ul><li>Converts hydrocarbons, CO and CO2 to CH4 for detection&nbsp;</li><li>Provides universal response across compounds&nbsp;</li><li>Quantitates the above using just one calibration curve</li></ul><h3>4. Thermo Fisher Scientific: Measuring destruction efficiency of greenhouse gases released by semiconductor fabrication tools</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/AN_54654_MAX_i_R_Semi_Febrication_EN_9ce9475305.pdf">Full PDF for download</a></li></ul><h4>Background&nbsp;</h4>Modern materials processing activities involve the use of cold plasmas employing fluorinated gases as reactive species. Some of these gases have been demonstrated to exhibit deleterious environmental consequences resulting in their being labelled as greenhouse gases or GHGs. Among the list of GHGs undergoing intense review are those of fluorinated gases, such as NF3, CF4 , SF6, CH2F2 , etc. Many of these gases are either reactants or are generated as by-products of semiconductor wafer fabrication processes, such as etching and chemical vapor deposition. Therefore, semiconductor fabrication plants (SemiFabs) employ abatement tools to destroy and dilute these fluorinated gases before they reach a stack scrubber. This process assures that they will meet EPA regulations which require yearly facility-dependent GHG emission audits. European and Asian semiconductor manufacturers must meet similar regulations as well.&nbsp;<h4>Problem&nbsp;</h4>To ensure that the abatement process occurs efficiently, SemiFabs are required to audit selected abatement devices (one per each wafer processing tool employed) such that each device gets periodically reviewed for efficiency in destroying these GHGs before they are released to the scrubber. Since there are hundreds of abatement devices within a single SemiFab, the monitoring process must be accurate, fast (one or two hours), and able to monitor multiple fluorinated species simultaneously. Most SemiFabs utilize a series of devices to perform the necessary measurements required to calculate an overall destruction efficiency for each fluorinated species. Among the measurements required are the dilution factor (the overall ratio of the flowrate into the abatement device to that of the flowrate out of the abatement device). In most cases, this requires the use of a krypton gas tracer and a mass spectrometer (for measurement of flowrate out) in addition to an FTIR to measure a separate infrared-active gas tracer (for measurement of flowrate in). Also required is another more sensitive FTIR to measure the residual fluorinated gases which survived destructive processes within the abatement device. The result is a very bulky and cumbersome system to measure input and output flows and concentrations. What is needed is a much simpler and fully integrated measurement system capable of performing ALL these tasks.<h4>Solution&nbsp;</h4>Thermo Fisher Scientific has developed a new methodology for measuring abatement destruction efficiencies with a much simpler system. The system uses the Thermo Scientific™ MAX-iR™ FTIR Gas Analyzer with DTGS detector in conjunction with the Thermo Scientific™ Automated Sample Console (ASC-10™). The MAX-iR analyzer can monitor the entire IR spectral range (500-5000 cm-1) without the need for liquid nitrogen. The ASC-10 allows for the precise measurement of post-abatement flow by determining the dilution of a tracer infrared gas or gases; this obviates the need for a spacious and costly mass spectrometer and krypton gas utilized in the previous system.</div></div></div></div></div></div></section></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 31, 2026

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<div><h4>Navigating Challenges and Opportunities for Environmental Testing Labs Under the Revised EU Water Framework Directive</h4>The European Commission’s proposed updates to the Water Framework, Groundwater, and Environmental Quality Standards Directives are bringing new responsibilities and opportunities for environmental testing labs. With expanded pollutant lists - including PFAS, pharmaceuticals, and pesticide metabolites - and stricter monitoring and reporting requirements, the landscape of water analysis is rapidly evolving.Join the 4th Waters Environmental Webinar Series to explore how your lab can navigate these challenges and turn regulatory change into opportunity.Register for free and partner with us to shape the future of European water quality.<h5>Why Attend</h5>Stay ahead of new EU regulatory demands with insights from leading experts. Gain practical guidance, share experiences with peers, and prepare your lab for the next generation of water quality standards.<h5>Highlights</h5><ul><li>New pollutant categories and analytical challenges</li><li>Updates to monitoring protocols and reporting</li><li>Innovative methods to meet revised Environmental Quality Standards</li><li>Strategic guidance for compliance and adaptation</li></ul>Lead the change in water analysis—stay ahead, stay compliant, and make a real impact.<h4>EPISODE 6: Blue Thursdays 2026 – The Best Of</h4>In this final session, we’ll look back at the most important things we’ve learned throughout the Blue Thursday series. We’ll explore the big trends we’re seeing, the smart tools scientists use to study the environment, and what exciting developments will be coming next.<blockquote>Speaker: Claudia Rathmann (Principal F&amp;E Market Development Manager, Waters Corporation)Experienced and passionate analytical science professional with over 20 years of technical and strategic expertise in food and environmental applications. Currently serving as Principal Market Development Manager at Waters Corporation, Claudia specializes in connecting customers with product management to deliver innovative solutions for complex analytical challenges. With a strong scientific foundation and a proven track record in both technical and marketing roles, Claudia bridges the gap between customer needs and product innovation across the EMEA region.Speaker: Janitha De-Alwis (JD) (Principal F&amp;E Market Development Manager, Waters Corporation)Janitha De-Alwis (known as JD) is an applications chemist in the European demo lab, based in Wilmslow, UK. His main role focuses on application development work for the food and environmental sector. JD takes great pride in speaking to, and advising, many food and environmental customers. His position requires him to be reactive and proactive to the changes in the food industry, such as changing regulations, topical issues and food safety risks.</blockquote></div>

Blue Thursdays 2026 – The Best Of

In this final session, we’ll look back at the most important things we’ve learned throughout the Blue Thursday series.

We probably have all experienced this at some point when performing gas chromatography and our peak shape begins to appear a bit different. &nbsp;In this webinar, we will discuss some of the most common chromatographic issues that you experience with Gas Chromatography and take a logical approach to finding the root cause and correcting the problem. Often the best way to approach troubleshooting is to also consider what ‘cannot’ cause an issue so that precious time is not spent addressing something that cannot cause the issue. This webinar will arm you with some simple tools, and a different way to look at troubleshooting, should a problem arise.<blockquote>Speaker: Alex Ucci&nbsp;In his current position at Agilent, Alex provides application assistance and technical support for sample preparation products as well as GC and LC consumables. Before he joined Agilent in 2014, Alex was a graduate student at the Pennsylvania State University researching the morphology and surface properties of aerosol particles using a wide variety of analytical techniques. He has an MS degree in chemistry.</blockquote>

Agilent Technologies: Becoming A Better Chromatographer Webinar Series

Essential Techniques for Gas Chromatography Troubleshooting

Learn essential GC troubleshooting techniques with Agilent. Discover a logical, time-saving root-cause analysis approach to fix poor peak shapes

Essential Techniques for GC Troubleshooting

This presentation will cover products from Agilent that make GC connections more robust by utilizing new technologies that make connections easier, leak free and more inert for any application.Topics covered include: Self Tightening Stainless Column Nuts and ferrules, Press Fits, UltiMetal Plus and Stainless Steel Capillary Tubing, Ferrule Pre-swaging installation tool and MS interface installation tool, among others.<blockquote>Speaker: Mark Sinnott (Technical Support Engineer, Consumables and Supplies Division, Agilent Technologies)Mark Sinnott works for Agilent Technologies as a Technical Support Engineer in the Consumables and Supplies Division (CSD). In his position at Agilent, Mark performs technical support and applications assistance to gas chromatographers worldwide. He has more than 22 years of experience in gas chromatography, including environmental analysis of compounds in air, soil and water matrices, including dissolved gas analysis for the electrical industry. Mark holds a Master’s Degree in Chemistry from California State University, Sacramento, and currently resides in Twin Falls Idaho.</blockquote>

Agilent Technologies: Becoming A Better Chromatographer - GC Webinar Series

From Inlet to Detector: Building Better Connections in GC and GC/MS Workflows

Build better GC and GC/MS connections with Agilent. Explore self-tightening column nuts, pre-swaging tools, and inert capillaries to eliminate leaks

Building Better Connections in GC and GC/MS Workflows

Keeping your GC system running smoothly isn’t just about good method development; it’s also about being prepared. In this webinar, we’ll walk through the essential consumables every lab should keep on hand to avoid unnecessary downtime. &nbsp;From gas traps and syringes to columns and detector supplies, we will discuss what supplies to stock and how this can help save valuable time.If you are about to purchase an instrument, we will also discuss critical items you’ll need to have on hand to ensure the installation is completed smoothly.Whether you’re new to GC or looking to optimize your workflow, this webinar will help ensure your system and your lab team stay up and running.<blockquote>Speaker: Ryan Mayfield (Field Service Engineer, Agilent Technologies)Ryan Mayfield has over 11 years of experience as a Field Service Engineer supporting GC and GCMS systems. &nbsp;He also delivers on-site application consulting for customers across a wide range of industries, including environmental, biotech, and petrochemical fields. &nbsp;He has a BS and MS in Food Science from UC Davis.Additional Speaker: Alex Ucci (Application Engineer, Agilent Technologies)In his current position at Agilent, Alex provides application assistance and technical support for sample preparation products as well as GC and LC consumables. Before he joined Agilent in 2014, Alex was a graduate student at the Pennsylvania State University researching the morphology and surface properties of aerosol particles using a wide variety of analytical techniques. He has an MS degree in chemistry.</blockquote>

Stocked for Success: Essential GC Supplies That Keep You Running

Stay prepared with essential GC supplies. Explore critical consumables, gas traps, and detector supplies needed to prevent downtime and ease installation

Essential GC Supplies to Keep Your System Up and Running

<div><div id="inner_content_body_text" data-content-id="394785">Polymers are complex materials, and understanding their performance requires more than just mechanical testing. Rheology provides valuable information on viscosity, elasticity, and flow, but it cannot fully explain the chemical and structural changes that occur during processing. By integrating rheology with Raman spectroscopy, researchers and engineers can correlate mechanical behavior with molecular-level insights in real time.This combined Rheo-Raman approach opens up new possibilities for understanding polymerization, crystallization, and thermal stability, supporting better formulation, troubleshooting, and quality control across the polymer industry.<h4>Key Learning Topics:</h4><ul><li>How Rheo-Raman correlates mechanical properties with chemical structure to deliver deeper insights into polymer behavior</li><li>How to monitor polymerization reactions and chemical transformations in real time</li><li>How to study crystallization pathways and their impact on material performance</li><li>How to assess thermal stability and degradation during processing or use</li><li>How Rheo-Raman supports faster material development, improved quality control, and problem-solving in industrial and research settings</li></ul><blockquote>Presenter: James P. Eickhoff Jr.James Eickhoff is the principal application engineer for the rheology division as a member of the Advanced Technical Support Center at Anton Paar USA. He has over 20 years of theoretical and experimental rheology training, including the last 17 years with Anton Paar having guided current and prospective customers on the use of rheological techniques in their industrial and academic research. James earned a Bachelor’s and Master’s Degree in Chemical Engineering from Michigan Technological University and Clemson University, respectively.</blockquote></div></div>

Anton Paar: Correlating Mechanical and Chemical Properties: Introduction to Rheo-Raman for Polymers

Correlating Mechanical and Chemical Properties: Introduction to Rheo-Raman for Polymers

Learn how Rheo-Raman combines rheology and Raman spectroscopy to study polymerization, crystallization, and polymer performance in real time.

Introduction to Rheo-Raman for Polymers

As materials become increasingly sophisticated, understanding their optical properties is essential for driving innovation, improving product performance, and ensuring quality. Whether developing anti-reflective coatings, optimising solar cell efficiency, designing specialty glass, or researching next-generation materials, accurate optical characterisation is a critical part of the workflow.Join us for this webinar to discover how the Agilent UV-Vis-NIR spectrophotometer enables researchers and industry professionals to measure and characterise a broad range of optical properties across diverse sample types and applications.The webinar will showcase measurement techniques for transmission, reflectance, diffuse reflectance, and angular measurements, highlighting how the Agilent UV-Vis-NIR platform delivers reliable and reproducible data for both research and industrial applications.<h4>Why Attend?</h4>In this session, you will learn:<ul><li>How the Agilent UV-Vis-NIR can be used to characterise thin films, coatings, solar materials, and glass.</li><li>Techniques for measuring transmission, reflectance, and diffuse reflectance with confidence.</li><li>Methods for determining film thickness and evaluating optical performance.</li><li>How specialised accessories expand measurement capabilities for challenging samples.</li><li>Best practices for obtaining accurate, reproducible results across a variety of applications.</li><li>Real-world examples demonstrating how optical measurements can accelerate research and product development.</li></ul><h4>Who Should Attend?</h4>This webinar is designed for:<ul><li>Academic Researchers and Students<ul><li>Researchers in materials science, physics, chemistry, and engineering.</li><li>Scientists investigating thin films, nanomaterials, optical materials, and photonic devices.</li><li>Graduate students and postdoctoral researchers seeking advanced optical characterisation techniques.</li></ul></li><li>Solar and Photovoltaics<ul><li>Scientists and engineers developing solar cells and photovoltaic materials.</li><li>Researchers evaluating anti-reflective coatings and light management strategies.</li><li>Teams working to improve solar cell efficiency through optical optimisation.</li></ul></li><li>Glass and Coatings Industries<ul><li>Manufacturers of architectural, automotive, and specialty glass.</li><li>Researchers developing low-emissivity and anti-reflective coatings.</li><li>Quality control and R&amp;D professionals responsible for optical performance testing.</li></ul></li><li>Advanced Materials and Industrial R&amp;D<ul><li>Thin film and semiconductor researchers.</li><li>Optical coating manufacturers.</li><li>Scientists working with displays, sensors, filters, and advanced functional materials.</li><li>Analytical laboratories requiring precise optical characterisation.</li></ul></li></ul><h5>Featured Applications</h5><ul><li>Thin film and multilayer coating analysis</li><li>Anti-reflective and optical coating characterisation</li><li>Solar cell and photovoltaic material evaluation</li><li>Optical filter transmission and blocking measurements</li><li>Architectural and specialty glass analysis</li><li>Reflectance measurements at varying angles of incidence</li><li>Film thickness determination</li><li>Diffuse reflectance measurements of scattering materials</li><li>Optical characterisation of emerging materials in academia and industry</li></ul>Discover how the Agilent UV-Vis-NIR platform combines exceptional optical performance, flexible sampling accessories, and intuitive workflows to provide the insights needed to advance research, optimise products, and solve challenging analytical problems.<blockquote>Presenter: Mr. Rajwar Chandra (Product Specialist - Spectroscopy, Agilent Technologies)Chandra Rajwar is a Product &amp; Market Specialist with over 20 years of experience in Molecular Spectroscopy products and analytical instrumentation. He specializes in UV-Vis, FTIR, Raman, and related spectroscopy solutions, supporting customers with application development, workflow optimization, and analytical excellence across pharmaceutical, chemical, environmental, and research industries.</blockquote><blockquote>Presenter: Ms. Vijaya Jyothi (Product Specialist - Spectroscopy, Agilent Technologies India Pvt. Ltd.)Vijaya Jyothi is a seasoned product specialist at Agilent Technologies. She manages the spectroscopy division, having extensive expertise in spectroscopy applications across diverse industries, offering deep insights and solutions tailored to varied analytical needs.</blockquote>

Agilent Technologies: Characterising Advanced Materials with the Agilent UV-Vis-NIR - From Thin Films and Solar Cells to Glass and Optical Coatings

Characterising Advanced Materials with the Agilent UV-Vis-NIR: From Thin Films and Solar Cells to Glass and Optical Coatings

Characterize thin films, solar cells, and coatings with Agilent UV-Vis-NIR. Master reflectance, transmission, and angular measurement workflows

Materials Characterization with Agilent UV-Vis-NIR

Diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) is a powerful technique for investigating catalyst surface chemistry under reaction conditions. In this live webinar, subject matter specialists from Michigan State University, Specac, and Thermo Fisher Scientific will discuss how in situ DRIFTS can be used to study dry reforming of methane over ceria-supported catalysts and provide insight into the surface species and reaction intermediates involved in catalytic CO₂ utilization.The session will explore DRIFTS experimental setup considerations, approaches for relating spectral observations to catalyst behavior, and examples of how researchers use in situ spectroscopy to investigate CO₂ activation and metal-support interactions. Presenters will also discuss complementary characterization techniques, including CO-DRIFTS, CO₂-DRIFTS, and CO₂-TPD-DRIFTS, and their role in catalyst research workflows.Attendees will be able to gain practical knowledge that can help strengthen catalyst characterization strategies, support experimental design, and improve interpretation of catalyst behavior in heterogeneous catalysis research.<h4>Key takeaways</h4>By attending this webinar, you can learn several aspects about this specific method of analysis:<ul><li>Apply in situ DRIFTS to investigate catalyst surface chemistry under reaction conditions</li><li>Monitor adsorbed species and reaction intermediates during dry reforming of methane</li><li>Relate spectral observations to catalyst behavior and reaction mechanisms</li><li>Investigate CO₂ activation and metal-support interactions in ceria-supported catalyst systems</li><li>Evaluate when to use complementary techniques such as CO-DRIFTS, CO₂-DRIFTS, and CO₂-TPD-DRIFTS</li><li>Incorporate DRIFTS into catalyst characterization workflows to support more informed research and development decisions.</li></ul><h4>Who should attend</h4><ul><li>Catalysis researchers</li><li>Materials scientists</li><li>Surface scientists</li><li>FTIR and vibrational spectroscopy users</li><li>Academic researchers studying heterogeneous catalysis</li><li>Scientists involved in catalyst development and characterization</li><li>Researchers working in CO₂ utilization, carbon management, and sustainable catalysis</li></ul><blockquote>Presenter: Md Monir Hossain, PhD Candidate, Michigan State UniversityResearcher focused on heterogeneous catalysis, carbon utilization, and DRIFTS studies of ceria-supported catalysts for dry reforming of methane.Presenter: Jim Delaney, Applications Team Lead, SpecacLeader of global spectroscopy application development and customer engagement efforts, supporting advanced research and industrial spectroscopy workflows.Presenter: Lena Woodis, PhD Product Manager, Thermo Fisher ScientificVibrational spectroscopy veteran with more than 15 years of experience in chemical instrumentation, FTIR spectroscopy, and analytical technologies.</blockquote>

Thermo Fisher Scientific: From Spectra to Mechanism: Using DRIFTS to Understand CO₂ Catalysis

From Spectra to Mechanism: Using DRIFTS to Understand CO₂ Catalysis

In this webinar, subject matter specialists will discuss how in situ DRIFTS can be used to study dry reforming of methane over ceria-supported catalysts.

Using DRIFTS to Understand CO₂ Catalysis

Exhaled breath is increasingly recognized as a powerful source of molecular information for personalized medicine. Containing hundreds to thousands of volatile organic compounds (VOCs) that reflect metabolic, inflammatory, microbiological, and environmental processes, breath offers a unique, completely non-invasive window into human health. Yet, unlocking this chemical complexity requires analytical platforms capable of delivering both exceptional separation power and high-confidence molecular characterization.At the forefront of this evolution is comprehensive two-dimensional gas chromatography coupled with mass spectrometry (GCxGC-MS), which has emerged as a cornerstone technology in modern breathomics. By significantly expanding chromatographic peak capacity and resolving power compared with conventional one-dimensional approaches, GCxGC-MS enables a more comprehensive exploration of the human volatilome and facilitates the discovery of clinically relevant biomarkers that would otherwise remain undetected.This webinar will explore how advanced GCxGC-MS workflows are transforming breathomics research and accelerating its translation towards clinical implementation. Drawing on recent developments in untargeted and targeted analytical strategies, we will discuss how comprehensive volatilome profiling can be integrated with rapid and streamlined methodologies to create efficient multi-platform pipelines for biomarker discovery, validation, and routine application. Particular emphasis will be placed on the critical role of analytical design, quality control, and data processing in generating robust and reproducible results from highly complex breath samples.Beyond technology development, the presentation will address the key challenges facing the field, including standardization of sampling protocols, harmonization of analytical methodologies, and the transition from exploratory studies to clinically actionable solutions. Real-world applications will illustrate how breathomics can support disease detection, patient stratification, therapeutic monitoring, and precision healthcare.As analytical capabilities continue to advance, GCxGC-MS is positioning breathomics to move beyond proof-of-concept studies and towards a future where non-invasive molecular phenotyping becomes an integral component of personalized medicine.<blockquote>Speaker: Anaïs Rodrigues (Applications Chemist, LECO Europe)</blockquote><blockquote>Speaker: Pierre-Hugues Stefanuto (Lead Scientist &amp; Senior Lecturer, Liège University, Belgium)</blockquote>

LECO: Breathomics - Advancing Personalized Medicine Through Next-Generation Analytical Solutions 

Breathomics: Advancing Personalized Medicine Through Next-Generation Analytical Solutions

Discover how GCxGC-MS transforms breathomics and VOC profiling. Learn how non-invasive molecular phenotyping enables personalized medicine

Breathomics & GCxGC-MS for Personalized Medicine

Laboratories are under growing pressure to handle increasing volumes of samples and data while operating under tighter regulatory inspection, all without compromising turnaround times or traceability. In this context, many organizations attempt to extend existing workflows and legacy tools, which can introduce inefficiencies, increase manual effort, and create compliance risks. At the same time, it is not always clear which digital solutions are best suited to address these challenges.This presentation illustrates how modern digital laboratory environments streamline routine activities by minimizing manual tasks and embedding compliance directly into everyday workflows. Drawing on a real-world use case, we show how automated capture of data from multiple sample measurements at the point of execution enables a continuous, sample-centric workflow.By removing manual interventions and paper-based processes, laboratories can improve efficiency and visibility, support faster and more reliable decision-making while remaining responsive to evolving customer demands.<h4>Learning Points</h4><ul><li>The role of different systems (LIMS, SDMS, ELN) within the digital lab landscape and how they differ from each other's</li><li>How WebLab manages laboratory operations from a sample perspective, enabling you to track every sample, stage, and next action across workflows</li><li>How automated data capture from connected instruments helps reduce errors, lower contamination risks, and accelerate sample processing</li><li>You will see, through a real-life example, how integrated digital workflows improve data quality, accelerate reporting, and increase operational efficiency</li></ul><h4>Who should attend</h4>Professionals working in small to mid‑sized laboratories, including:<ul><li>Directors and Managers of Analytical, QC, or Contract Labs</li><li>Lab Operations and QA/QC Leaders</li><li>Digitalization and IT at organizations transitioning from paper, Excel, or legacy systems to LIMS</li></ul><blockquote>Presenter: Peter Bellstedt, PhD (Director of Business Development and Product Manager at SciY)Peter studied Biochemistry at the University of Jena before completing a PhD on the structural characterization of a DNA repair protein using solution and solid-state NMR. He was then appointed as the head of the NMR Spectroscopy Platform in Jena, Germany, where he pioneered the implementation of modern, highly efficient data-driven workflows. After five years, he moved to the University of Zurich, Switzerland, as a principal investigator, where his lab focused on structure-based drug discovery. This year, he brought his wealth of experience to the LOGS by SciY team, focusing on efficient workflow solutions for research labs and facilities on a global scale.</blockquote>

SciY: From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision

From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision

Transition from paper to a paperless lab. Discover how WebLab, LIMS, and automated data capture streamline sample tracking and boost compliance

Paperless Labs & Sample Tracking: Digital LIMS Workflows

The challenge of developing and maintaining robust chemometric models for use within Process Analytical Technology (PAT) deployment remains a significant barrier to implementation. This webinar explores how Iterative Optimization Technology (IOT) is advancing the principles of lean chemometrics by reducing the calibration burden associated with PAT deployment. Case studies will demonstrate how these methods enable faster model deployment, improved lifecycle management, and greater operational efficiency without compromising product quality or process understanding. Attendees will gain insights into how innovative chemometric strategies can accelerate PAT adoption while supporting the industry's drive towards agile, data-driven manufacturing.<h4>Learning Points</h4><ul><li>You will learn how lean chemometrics reduces model complexity and data requirements</li><li>Discover how to simplify model deployment and lifecycle management</li><li>Explore how to accelerate PAT adoption while maintaining process understanding and quality</li></ul><h4>Who should attend</h4><ul><li>Process development and MSAT teams scaling processes to manufacturing</li><li>PAT scientists and analytical experts developing chemometric models</li><li>Lab managers driving efficient and scalable PAT implementation</li><li>Development and manufacturing and digitalization leaders advancing data-driven operations</li></ul><blockquote>Presenter: Jonique Samuels (Scientific Advisor for Innovations, SciY)Jonique Samuels is a Scientific Advisor for Innovations at SciY where she leads research and development projects on new, novel functionality for synTQ, the orchestration and real-time process-control platform that enables PAT and advanced, quality-centric control strategies. Currently, Jonique's focus is on supporting sustainability initiatives with customers, which includes investigating and developing lean chemometrics methods.&nbsp;</blockquote><blockquote>Presenter: Anna Codina, Ph.D. ( Senior Director Strategy and Business Development, SciY)Anna Codina is Senior Director of Strategy and Business Development at SciY, where she focuses on enabling data-driven orchestration across the pharmaceutical value chain. With a background in experimental science, analytical development, and digital innovation, she works at the intersection of data, automation, and AI to accelerate scientific workflows and decision-making.Anna holds a Ph.D. in protein NMR from the University of Barcelona and completed postdoctoral research at the MRC Laboratory of Molecular Biology in Cambridge. She spent seven years in Analytical R&amp;D at Pfizer, specializing in reaction monitoring, impurity characterization, and regulatory submissions, and was recognized with a Pfizer Worldwide Achievement Award for implementing NMR-based reaction monitoring in an open-access environment.Since joining Bruker, Anna has held multiple leadership roles across applications, product management, and biopharma business development and market management. In her current role at SciY, she drives strategy for vendor-agnostic data platforms and digital solutions that connect instruments, robotics, and enterprise systems enabling orchestration, AI-powered experimentation and scalable workflows across R&amp;D, CROs/CDMOs, and manufacturing.</blockquote>

SciY: Advancing Lean Chemometrics: Iterative Optimization Technology as a Process Analytical Technology Tool for Reducing Calibration Burden

Advancing Lean Chemometrics: Iterative Optimization Technology as a Process Analytical Technology Tool for Reducing Calibration Burden

Reduce PAT calibration burden with Lean Chemometrics and IOT. Learn to accelerate model deployment and simplify lifecycle management in this webinar

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News from LabRulezGCMS Library - Week 31, 2026

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