Unlocking the Potential: Raman Spectroscopy as Real-time Process Analytical Technology (PAT) for Automation and Enhanced Bioproduction

Real-time analytics using in-line and on-line technologies provide valuable insights into bioprocess parameters and cell-feeding strategies. Leveraging Process Analytical Technology (PAT), bioproduction processes can be optimized to deliver exceptional results. This includes developing scalable and transferrable processes in monoclonal antibody (mAb) bioproduction. PAT is a game-changer in the bioproduction industry, empowering manufacturers to stay ahead in a highly competitive market.

In this webinar, Dr. Nimesh Khadka, a senior R&D scientist at Thermo Fisher Scientific, will discuss how PAT in bioproduction is revolutionizing how premium products can be developed and manufactured. He will also explore the benefits of the implementation of PAT in bioproduction, including improved process efficiency, reduced manufacturing costs, and the ability to deliver high-quality products consistently.

Key learning objectives

• Learn what the advantages are of Raman Spectroscopy as Process Analytical Technology (PAT)
• Explore case studies that show the implementation of Raman as PAT for upstream and downstream processes
• Understand how to use chemometrics as a tool to extract useful information from the complex matrix
• Discover how the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer is a reliable, scalable, and accurate instrument with minimum inter-instrument variability allowing model transferability across instruments

Who should attend?

• Process engineers
• PAT scientists
• Process development & team leaders
• R&D team leaders
• Process improvement champions
• Those working in cell culture/bioproduction

Certificate of attendance

All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

Presenter: Dr. Nimesh Khadka (Thermo Fisher Scientific)

Dr. Nimesh Khadka is a senior R&D scientist with the Field Safety Instruments at Thermo Fisher Scientific, specializing in analytical biochemistry, spectroscopy, and chemometrics. He currently champions Raman spectroscopy as process analytical technology (PAT) for developing protein and nucleic acids therapeutics. He completed his Ph.D. at Utah State University, focusing on enzymology, spectroscopy, and alternative bio-energy. His postdoctoral training was conducted at Case Western Reserve University, where he dedicated his research to studying structural biology in biomolecules associated with eye pathologies. As an active member of the American Chemical Society, he remains at the forefront of emerging technologies and is committed to driving innovation to meet customer’s needs.

Presenter: Will Thompson (SelectScience)

Will studied Biology at the University of Bristol, UK, and as a member of the Editorial team, he now plays an integral role in shaping the content on SelectScience.