GC Coupling to LC-MS Instruments - Expand your Mass Spectrometric “View” with SICRIT

SICRIT® GC-Coupling Advantages

1. Combination of LC-MS detection and GC separation enables more rigor and fast identification of analytes

2. Ionization mechanism allows to cover a broader range of analytes – previously different systems required

3. Soft ionization delivers molecular ion peaks and avoids complex and challenging allocation due to fragmentation

4. Soft ionization allows to apply advanced detection models like SWATH or Data Dependent Acquisition (DDA)

5. Combination with HRMS enables addition reliability in terms of substance identification

Conventional Ionization Technologies

With conventional atmospheric pressure methods, the ions are mostly formed outside the inlet of an MS. This implies that the substance to be analyzed (e.g. coffee) cannot be analyzed directly, but is usually "sprayed" into the MS in the form of a sample (liquid extract) via the ionization source.

SICRIT® Technology

The SICRIT® (Soft Ionization by Chemical Reaction In Transfer) ionization source is interfaced with the atmospheric pressure inlet of the MS and ionizes every substance which is drawn into the MS by its inherent vacuum.

Plasmion: Conventional MS Ionization Technologies vs. SICRIT® Technology

SICRIT® Characteristics

• Simple extension of MS inlet
• Concentric dielectric barrier discharge
• Sample ionized during transfer into MS
• Soft ionization by proton transfer and UV light
• No consumables