<p><strong>🎤Alex Brody</strong></p><p><strong>In this episode of Concentrating on Chromatography, we sit down with Alex Brody, an organic chemist at Aqua America, to discuss the rigorous analytical methods required for regulated drinking water testing.</strong></p><p>Alex walks us through the multi-step PFAS detection process using EPA Method 537.1, including extraction, nitrogen blowdown concentration, and LC-MS analysis. He explains why sample preparation and quality control are critical for achieving trace-level detection—and why these methods can't be rushed or simplified, even with new technologies available.</p><p>We also explore taste and odor investigations, disinfection byproducts, and volatile organic compounds, plus the surprising reality of why regulated labs move slowly when adopting new instrumentation. You'll learn about the quality control checkpoints, peer review processes, and the misconceptions surrounding analytical turnaround times in compliance labs.</p><h5><strong>Topics Covered:</strong></h5><ul><li>Role of organic chemistry in regulated drinking water labs</li><li>EPA compliance requirements and regulatory bodies (EPA, PA-DEP)</li><li>PFAS detection using Method 537.1 and LC-MS</li><li>The critical importance of nitrogen blowdown sample concentration</li><li>Taste and odor analysis: MIB, Geosmin, and unknown compound identification</li><li>Why regulated methods evolve slowly (validation timelines, approval processes)</li><li>Quality control procedures: calibration checks, matrix spikes, surrogate standards, internal standards</li><li>Automated sample preparation and lab efficiency</li><li>Future PFAS regulations and Method 533 expansion</li></ul><h5><strong>Ideal For:</strong></h5><ul><li>Analytical chemists and environmental lab professionals</li><li>Water utilities and compliance officers</li><li>Chromatography practitioners interested in regulated workflows</li><li>Anyone curious about how drinking water safety is ensured</li></ul><h2><strong>Video Transcription</strong></h2><h3><strong>Ensuring Safe Drinking Water Through Advanced Analytical Chemistry</strong></h3><h4><strong>Insights from a Regulated Water Testing Laboratory</strong></h4><p>Analytical laboratories responsible for regulated drinking water testing operate under strict compliance frameworks to ensure the delivery of safe and reliable water supplies. In this interview, Alex, an organic chemist at Aqua America, outlines the scope of analytical work conducted in a modern water quality laboratory. The team primarily focuses on the determination of taste- and odor-causing compounds, disinfection byproducts, volatile organic compounds (VOCs), and per- and polyfluoroalkyl substances (PFAS). These analyses rely heavily on <strong>GC-MS and LC-MS instrumentation</strong>, supported by rigorous maintenance programs to ensure continuous operational performance and data reliability.</p><h4><strong>Regulatory Compliance and Quality Control in Drinking Water Analysis</strong></h4><p>Operating as a regulated drinking water laboratory requires adherence to stringent requirements established by agencies such as the <strong>U.S. Environmental Protection Agency (EPA)</strong> and state-level regulatory bodies. Compliance is driven by extensive quality control protocols integrated into every analytical batch. Typical workflows include calibration verification, matrix spike recovery assessments, internal standard monitoring, and surrogate performance checks. Notably, analytical batches are often limited in sample number to accommodate a substantial proportion of quality control samples, reflecting the critical importance of data defensibility in regulatory reporting.</p><p>One common misconception is the perceived speed at which results can be delivered. In reality, comprehensive sample preparation, including extraction procedures and validation steps, can extend turnaround times to a full working day or longer. Additionally, validated regulatory workflows impose limitations on the rapid adoption of new analytical technologies, as method modifications must undergo formal evaluation and approval before implementation.</p><h4><strong>Analytical Strategies for Taste and Odor Investigations</strong></h4><p>Taste and odor events represent a significant operational challenge for water utilities. Standard targeted methods are routinely applied for compounds such as <strong>2-methylisoborneol (MIB)</strong> and <strong>geosmin</strong>, which are commonly associated with earthy or musty sensory characteristics. When targeted analysis does not reveal the source, laboratories employ <strong>broad-scan GC-MS screening</strong> combined with spectral library interpretation to identify potential causative compounds. In some cases, sensory evaluation panels complement instrumental analysis, providing preliminary insight into potential treatment-related or environmental influences affecting water quality.</p><h4><strong>PFAS Monitoring: Methodological Complexity and Trace-Level Sensitivity</strong></h4><p>PFAS determination represents a rapidly evolving priority in drinking water monitoring. The laboratory currently applies <strong>EPA Method 537.1</strong>, with efforts underway to expand capabilities through certification for <strong>Method 533</strong>, thereby broadening analyte coverage. Analytical workflows typically involve solid-phase extraction followed by solvent evaporation using nitrogen-assisted blow-down techniques to achieve the trace-level sensitivity required for regulatory compliance. This concentration step is essential because PFAS compounds remain non-volatile under controlled evaporation conditions, enabling enhanced detection performance upon reconstitution and LC-MS analysis.</p><h4><strong>Future Directions in Drinking Water Analytics</strong></h4><p>Looking ahead, the primary technological driver in regulated water analysis is the demand for <strong>increasingly lower detection limits</strong> and expanded compound coverage. While regulatory frameworks can slow methodological innovation, laboratories continue to pursue efficiency improvements, such as automated sample preparation systems and optimized analytical workflows. These advances support the growing need to process high sample volumes while maintaining the stringent data quality standards required for public health protection.</p><p>Ultimately, the work performed in regulated drinking water laboratories represents a critical intersection of analytical chemistry, environmental monitoring, and public safety. Continuous methodological refinement, coupled with advances in mass spectrometry and sample preparation technologies, will play a central role in addressing emerging contaminants and ensuring long-term water quality assurance.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

Regulated Drinking Water Testing: PFAS Detection, Sample Prep & Real Lab Insights

<p><strong>This study investigates the chemical transformations of Eugenia uniflora essential oil under thermal conditions simulating gas chromatography analysis. GC–MS and NMR revealed that sesquiterpenes of the germacrene type, such as furanodiene, undergo sigmatropic rearrangement to form elemene-type compounds, including curzerene.</strong></p><p>Thermal treatment confirmed the formation of rearrangement products, indicating that bioactive properties historically attributed to curzerene may instead originate from furanodiene. The findings highlight the importance of combining complementary analytical techniques, such as NMR, to avoid misinterpretation of essential oil composition and bioactivity markers.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c08966"><strong>Is Curzerene Responsible for the Bioactive Properties of Eugenia uniflora? A Possible Misinterpretation of Bioactive Markers</strong></a></h4><p>Vinicius Monteiro Schaffka, Raphaela Pereira Guaringue, Larissa Kozan, André Luis Kerek, Cássia Gonçalves Magalhães, Andersson Barison, and Barbara Celânia Fiorin*</p><p>ACS Omega 2025, 10, 48, 59425–59434</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acsomega.5c08966">https://doi.org/10.1021/acsomega.5c08966</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><div><p>Essential oils are a matrix of volatile and complex compounds characterized by strong odors and significant biological activity. In plants, they play a crucial role in defense against bacteria, viruses, and predators. <a href="javascript:void(0);">(1)</a> These biological properties support the extensive use of essential oils in the food, cosmetics, and pharmaceutical industries. <a href="javascript:void(0);">(1,2)</a> <i>Eugenia uniflora</i> L., commonly known as pitangueira, is a native Brazilian tree widely distributed across South America and is well-known for its bioactive essential oil. <a href="javascript:void(0);">(3)</a> Beyond the consumption of its fruits in natura or functional beverages, its leaves are used in infusions, decoctions, and tinctures to treat a variety of diseases, including diarrhea, stomach pain, worm infestations, fever, flu, hyperglycemia, hyperlipidemia, and hypertension. <a href="javascript:void(0);">(4,5)</a> Studies have shown that the composition of secondary metabolites in <i>E. uniflora</i> can vary depending on factors such as fruit color, ripening stage, <a href="javascript:void(0);">(6)</a> and seasonal influences. <a href="javascript:void(0);">(4,7−10)</a></p><p>The essential oil of <i>E. uniflora</i> is predominantly composed of sesquiterpenes, mainly germacrene-type, such as curzerene, germacrene B, germacrone, germacrene D, selina-1,3,7(11)-trien-8-one, and its oxide. Additionally, Elemene-type terpenes are also reported, including furanodiene, β-Elemene, and β-Elemenone. <a href="javascript:void(0);">(11−13)</a></p><p>However, those sesquiterpenes are well-documented for their thermal instability. When heat is applied, germacrene-type sesquiterpenes undergo a [3,3]-sigmatropic rearrangement, known as Cope rearrangement, converting into Elemene-type terpenes as presented in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c08966#fig1">Figure 1</a>. <a href="javascript:void(0);">(14−16)</a> This reaction is widely utilized as a synthetic pathway to produce Elemenes from germacrene precursors. <a href="javascript:void(0);">(17,18)</a></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_48_59425_59434_Figure_1_3_3_Sigmatropic_rearrangement_of_Germacrene_type_into_Elemene_type_250708e73c.jpg" alt="ACS Omega 2025, 10, 48, 59425–59434: Figure 1. [3,3]-Sigmatropic rearrangement of Germacrene-type into Elemene-type." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_48_59425_59434_Figure_1_3_3_Sigmatropic_rearrangement_of_Germacrene_type_into_Elemene_type_250708e73c.jpg 245w," sizes="100vw" width="3000" height="984"></p><p>Gas chromatography (GC) is the main technique for characterizing essential oils, often coupled with mass spectrometry (GC-MS) and the retention index determination is used in the identification of the compounds through comparison with databases. <a href="javascript:void(0);">(21)</a> During GC analysis, essential oils are subjected to multiple heating stages. Initially, the sample is exposed to a high inlet temperature, typically around 240 °C, to ensure complete volatilization. It then enters the oven, where the temperature follows a programmed ramp starting at 60 °C, increasing at 3 °C/min, and reaching up to 240 °C. Finally, the sample encounters the elevated temperatures of the mass spectrometry (MS) detector’s source (250 °C) and interface (280 °C). Even in isocratic methods, where the oven temperature remains constant throughout the analysis, the inlet, source, and interface temperatures are maintained at high levels. Although the sample passes through these stages briefly, the elevated temperatures can induce Cope rearrangements in the essential oil, leading to possible changes in its composition. <a href="javascript:void(0);">(22,23)</a></p><p>The accurate characterization of the chemical composition of essential oils is crucial for any study employing them as a biological or analytical matrix, as it supports the interpretation of bioactivity, chemotaxonomic classification, and quality control of samples with economic value added. There are many studies attributing relevant biological activities, classifying specimens, and identifying phenotypic and genetic variations based on the chemical composition of the essential oil of <i>E. uniflora</i> L., which is usually characterized by GC-MS. <a href="javascript:void(0);">(8,9,11,24)</a> As an example of the study carried out by de Jesus, found acute anti-inflammatory effect of a rich in curzerene essential oil. <a href="javascript:void(0);">(5)</a> Similarly, Pascoal, reported distinct essential oil composition patterns among <i>E. uniflora</i> varieties─yellow, red, and purple fruits─primarily driven by variations in β-Elemene and germacrene D content. <a href="javascript:void(0);">(7)</a> These findings highlight metabolic changes during fruit ripening and underscore the influence of genetic diversity among <i>E. uniflora</i> varieties. Such exhibitions are unsatisfactory, because they sustain all their evidence in the characterization of their essential oil only by GC-MS analysis, without considering the Cope rearrangements, a fact that may change the outcome of their research. In this context Nuclear Magnetic Resonance (NMR) spectroscopy is a good alternative for essential oil analysis, since is a robust not destructive technique and able to detect and quantify simultaneously a wide range of metabolites that exceed the concentration of about 5–10 μM. <a href="javascript:void(0);">(25)</a></p><p>In order to highlight analytical concerns about the uses of only GC-MS data to access chemical relevance of <i>E. uniflora</i> essential oil studies, Nuclear Magnetic Resonance (NMR) spectroscopy was employed to evaluate the chemical composition of the essential oil of <i>Eugenia uniflora</i> L. before and after an induced thermal treatment, compared to GC-MS data. The findings provide insights into thermolabile compounds and highlight potential misidentifications of the bioactive properties associated with the sesquiterpenes of <i>E. uniflora</i> present in literature.</p><h4><strong>2. Results and Discussion</strong></h4><h5><strong>2.1. Characterization of the Essential Oil</strong></h5><p>Approximately 60 compounds, mostly sesquiterpenes (Germacrene B) and oxygenated sesquiterpenes (Germacrone), were visualized in the essential oil, with the 9 compounds having a relative area above 2%, as shown in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c08966#tbl1">Table 1</a>. The identified and most prevalent compounds align with those reported in the literature for <i>E. uniflora</i>. <a href="javascript:void(0);">(4,11,12)</a> It is possible to highlight the significant proportion of Germacrene-type sesquiterpenes compared to Elemene-type, except Curzerene, which was found in high concentration.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_48_59425_59434_Table_1_Main_Components_Identified_in_the_GC_MS_Analysis_of_the_Essential_Oil_from_Leaves_of_E_uniflora_9d59d96bef.jpg" alt="ACS Omega 2025, 10, 48, 59425–59434: Table 1. Main Components Identified in the GC–MS Analysis of the Essential Oil from Leaves of E. uniflora." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_48_59425_59434_Table_1_Main_Components_Identified_in_the_GC_MS_Analysis_of_the_Essential_Oil_from_Leaves_of_E_uniflora_9d59d96bef.jpg 218w," sizes="100vw" width="1076" height="771"></p><p>The variation in the composition of the essential oil from <i>E. uniflora</i> leaves was described in literature, <a href="javascript:void(0);">(9)</a> who classified the specimens into three groups: Group I, containing yellow, dark red, and purple fruits, which showed high concentrations of germacrene B, germacrone, and atractylone; Group II, consisting of light red fruit samples, with high concentrations of curzerene, germacrene D, and germacrene A; and Group III, containing orange-red fruits, with a high content of selina-1,3,7(11)-trien-8-one and oxyselina-1,3,7(11)-trien-8-one. According to this classification, this essential oil fits into Group II.</p><p>Chemical transformations of many components found in the <i>E. uniflora</i> leaves essential oil result from the heating conditions typically applied during GC–MS analysis, which occur through Cope Rearrangement. <a href="javascript:void(0);">(12,19)</a> Cope rearrangement is a stereospecific [3,3]-sigmatropic rearrangement that proceeds via the most stable chairlike transition state of 1,5-cyclodecadiene, from germacrene-type, to give 1,2-divinylcyclohexane, known as Elemene-type. <a href="javascript:void(0);">(14)</a> Some of the Cope rearrangements found in the <i>E. uniflora</i> essential oil are represented in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c08966#fig2">Figure 2</a>. <a href="javascript:void(0);">(11,22,23,26)</a></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_48_59425_59434_Figure_2_Cope_Rearrangements_of_sesquiterpenes_7fe9282d75.jpg" alt="ACS Omega 2025, 10, 48, 59425–59434: Figure 2. Cope Rearrangements of sesquiterpenes." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_48_59425_59434_Figure_2_Cope_Rearrangements_of_sesquiterpenes_7fe9282d75.jpg 150w," sizes="100vw" width="1500" height="1566"></p><p>The same essential oil was analyzed using NMR spectroscopy to identify its components. Although NMR identification is considerably more labor-intensive than GC-MS analysis, it offers the advantage of being a cold and nondestructive technique. Since the sample does not undergo heating during the process, its stability is preserved throughout the analysis. The conformational differences observed in germacrene-type compounds further increase the spectrum’s complexity, leading to signal broadening in the <sup>1</sup>H NMR spectra. <a href="javascript:void(0);">(27)</a></p><p>A substantial number of signals were observed in the <sup>1</sup>H spectrum, with the majority concentrated between 0.5 and 3.0 ppm, a region characteristic of terpene compounds. The region between 4.5 and 6.0 ppm also exhibited numerous signals attributed to vinylic protons, observed in sesquiterpenes (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c08966#fig3">Figure 3</a>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_48_59425_59434_Figure_3_1_H_NMR_400_13_M_Hz_CD_Cl3_spectra_of_the_raw_essential_oil_a46e04574e.jpg" alt="ACS Omega 2025, 10, 48, 59425–59434: Figure 3. 1H NMR (400.13 MHz, CDCl3) spectra of the raw essential oil." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_48_59425_59434_Figure_3_1_H_NMR_400_13_M_Hz_CD_Cl3_spectra_of_the_raw_essential_oil_a46e04574e.jpg 245w," sizes="100vw" width="4175" height="2376"></p><h4><strong>3. Conclusions</strong></h4><p>The investigation of the composition of <i>E. uniflora</i> essential oil by NMR and the thermal treatment performed proved that curzerene may come from furanodiene due to the transformations that occur in the matrix during gas chromatographic analysis. These findings have significant implications for the investigation into the chemical composition of <i>E. uniflora</i> essential oil and the evaluation of the biological properties of its sesquiterpenes. Since each technique has advantages and disadvantages, combining GC-MS analysis with a cold technique, such as NMR is important to guarantee the proper identification of the compound genuinely responsible for any property assigned to <i>E. uniflora</i> essential oil.</p><h4><strong>4. Materials and Methods</strong></h4><h5><strong>4.2. GC-MS Analysis</strong></h5><p>The gas chromatographic analyses of the essential oils (10 mg mL<sup>–1</sup>) were performed using a gas chromatography–mass spectrometry system (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=QP2020"><strong>Shimadzu GCMS-QP2020 Gas Chromatograph</strong></a>). The analyses were conducted on an RTx-5MS capillary column (30 m × 0.25 mm internal diameter × 0.25 μm film thickness), and the analytical conditions were as follows: split ratio of 1/10, injector temperature at 250 °C, ion source at 250 °C, and interface at 280 °C. The temperature program of the oven was set at 60 °C for 5 min, followed by a temperature ramp of 3 °C/min until reaching the final temperature of 240 °C. The components were identified based on the relative retention index, calculated for each constituent by injecting a series of <i>n</i>-alkane standards (C8–C20) under the same sample conditions and comparing them with tabulated values as well as by comparing the obtained mass spectra with the mass spectra database and literature comparisons. <a href="javascript:void(0);">(21)</a></p><h5><strong>4.4. NMR Analysis</strong></h5><p>All NMR spectra were acquired at 298 K on a <strong>Bruker AVANCE III</strong> spectrometer operating at 9.4 T, observing <sup>1</sup>H at 400.13 MHz and <sup>13</sup>C at 100.13 MHz, equipped with a broadband probe. The essential oil was solubilized in CDCl<sub>3</sub> with 0.05% of tetramethylsilane (TMS) used as an internal reference. The <sup>1</sup>H NMR spectra were recorded utilizing 65k time-domain data points across a spectral width of 20.00 ppm. This setup provided a digital resolution of 0.24 Hz. The data were obtained using a single 30° excitation pulse, with a relaxation delay of 1.0 s, and an average of 128 scans. The <sup>13</sup>C NMR spectra was carried out using the <i>zgpg30</i> pulse sequence utilizing 64k time-domain data points across a spectral width of 238 ppm, with an acquisition time of 1.3631 s, providing a digital resolution of 0.7434 Hz and a relaxation delay of 2.0s and an average of 2k scans.</p><p>The HSQC and HMBC experiments were conducted using standard pulse sequences from the Bruker library, with modifications to the number of acquired points to improve resolution, 2048 in F2 and 512 in F1.</p></div>

Is Curzerene Responsible for the Bioactive Properties of Eugenia uniflora? A Possible Misinterpretation of Bioactive Markers

Quantitative Assessment of Chemical Modifications of Macromolecules through Counterion Measurement

Video

Scientists

Water

Scientific article

Interview

Science and research

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Thermo Scientific™ EA IsoLink™ IRMS System

With the Thermo Scientific™ EA IsoLink™ IRMS Platform, leverage familiar technology and existing expertise for expanded CNSOH isotope analysis, allowing all elemental analysis on a single platform.

<h3><strong>All your elemental analysis on one platform</strong></h3><p><strong>The EA IsoLink IRMS Platform leverages the existing technological platform of the EA IsoLink IRMS System and FlashSmart EA.</strong></p><h4><strong>More freedom. More flexibility.</strong></h4><p>With the<strong> Thermo Scientific™ EA IsoLink™ IRMS Platform</strong>, you can leverage familiar technology and your staff’s existing know-how for <strong>expanded CNSOH isotope analysis</strong>, enabling you to perform all your elemental analysis on one technological platform. With <strong>different configurations</strong> to choose from, your lab can get the capabilities it needs today, with flexibility for the future. Featuring software- driven automation and scalability to grow as you do.</p><h4><strong>Choose the configuration that’s right for you.</strong></h4><p>The<strong> EA IsoLink IRMS</strong> System is an automated, easy-to-use solution for <strong>isotopic analysis of carbon, nitrogen, sulfur, oxygen and hydrogen</strong> - using bulk samples powered by chromatography-driven technology with high sensitivity on small samples. Available in basic configurations with upgradeability options, this platform offers high throughput and unattended operation, so your lab can get more done in less time.</p><h4><strong>The EA IsoLink IRMS System features:</strong></h4><ul><li><strong>Thermo Scientific™ Flash™ IRMS EA</strong> for sample preparation for IRMS analysis</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2231"><strong>Thermo Scientific™ ConFlo IV</strong></a> Universal Interface</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2232"><strong>Thermo Scientific™ DELTA™ Q IRMS</strong></a></li></ul><h4><strong>The FlashSmart EA features:</strong></h4><ul><li><strong>Thermo Scientific™ FlashSmart™ EA</strong> for weight percentage characterization of CNSHO</li></ul><h3><strong>EA IsoLink CN and CN/OH</strong></h3><ul><li>A powerful solution for <strong>C and N, O and H analysis</strong> - upgradeable for <strong>S analysis</strong></li></ul><h3><strong>EA IsoLink OH</strong></h3><ul><li>Offering dedicated<strong> oxygen and hydrogen analysis </strong>- with scalability to expand your capabilities to <strong>C, N and S</strong></li></ul><h3><strong>EA IsoLink CNSOH</strong></h3><ul><li>A fully automated single system for <strong>C, N and S analysis </strong>by flash combustion, and <strong>O and H analysis</strong> by high temperature conversion</li></ul><h4><strong>Connectivity with Thermo Scientific™ IRMS Portfolio</strong></h4><p>The <strong>Flash EA Series</strong> connected to the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2232"><strong>DELTA Q IRMS</strong></a><strong> </strong>provides precise and sensitive measurement of the isotope fingerprints - <strong>C, N, S, O and H isotopes </strong>- a unique chemical signature of samples. This helps you gain unique insights into food history and origin, as well as environmental pollutants, forensics and geosciences.</p><figure class="image"><img style="aspect-ratio:650/552;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_EA_Iso_Link_IRMS_System_2_01d3ed421c.jpg" alt="Thermo Scientific™ EA IsoLink™ IRMS System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_EA_Iso_Link_IRMS_System_2_01d3ed421c.jpg 184w," sizes="100vw" width="650" height="552"></figure><h3><strong>More automation. More scalability. All in a single platform.</strong></h3><p><strong>Delivering proven performance with unprecedented robustness and ease of use, the EA IsoLink IRMS Platform can help your lab drive efficiency, improve cost-effectiveness, and minimize training for new operators.</strong></p><h4><strong>Low cost per sample for reduced operational costs</strong></h4><p><strong>Less helium consumption:</strong> Helium consumption is reduced by more than 60% for NCS and NC sample analysis, and reduced by more than 30% for OH sample analysis (compared with previous systems).</p><p><strong>Less replication:</strong> Because the EA IsoLink IRMS System measures high and low concentrations in the same sample (wide dynamic range), it reduces the need for replicate analysis (e.g., high carbon and low sulfur, such as in food authenticity or ecology applications).</p><p><strong>High throughput:</strong> Fast analysis provides high sample throughput, resulting in lower cost per sample.</p><h4><strong>High sensitivity driven by chromatography - even for the smallest sample size</strong></h4><p><strong>Temperature-ramped GC:</strong> Equipped with a temperature-ramped GC feature, the EA IsoLink System gives your lab the highest performance on small sample sizes through optimal baseline separation of analyte gases and sharp peak shapes.</p><p><strong>Performance synergies:</strong> The combination of in-line flash combustion technology and temperature-ramped GC separation significantly improves the performance for all your EA-IRMS applications.</p><h4><strong>System modularity for future-proof investment</strong></h4><p>The <strong>EA IsoLink IRMS</strong> System’s modular design provides the highest flexibility for all applications - enabling you to <strong>adapt and scale</strong> to new analyses in the future. Through smart upgrade paths, you can easily modify the system to increase performance and productivity as your needs grow over time. Boost your CN system with an S upgrade or add CNS to your OH isotope fingerprints.</p><p><strong>Thermo Scientific™ MAS Plus Autosampler</strong> provides a 125-position helium-purged sample chamber, low blank autosampler for CNS and OH analysis.</p><p><strong>Thermo Scientific™ AS 1610 Liquid Autosampler</strong> offers a versatile solution for injecting liquid samples.</p><p>Macro reactors enable CNS Analysis of large sample sizes (greater than 60 mg) and higher throughput on standard sample sizes to mg range.</p><h4><strong>Added flexibility with flash EA series</strong></h4><p>The flexibility of the Flash EA Series helps you meet growing analytical needs in<strong> IRMS and Organic Elemental Analysis</strong> (OEA).</p><p>The <strong>FlashSmart Elemental Analyzer</strong> for OEA delivers accuracy and precision with internationally recognized certifications. Its straightforward modular design offers a variety of optimized application configurations, including <strong>CHN, CHNS, S, N/Protein, CN, CNS, CHNS/O and more</strong>. High throughput with <strong>24/7</strong> operation, low cost per sample and optimized helium consumption are all driven by our fully automated dedicated OEA software, Thermo Scientific™ EagerSmart™ Data Handling Software, which can grow with your analytical needs without need for an upgrade.</p><h4><strong>Smart automation for ease of use</strong></h4><p>Because of its <strong>intelligent software</strong> and intuitive design, the EA IsoLink Platform allows operators to leverage familiar technology for higher productivity.</p><p><strong>Software Platform: </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>The Thermo Scientific™ Qtegra™ Intelligent Scientific Data Solution</strong> </a>(ISDS) Software provides seamless control and automation for unattended operation and improved productivity. Regardless of operator skills or the final application, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>Qtegra ISDS Software</strong></a> offers logical, streamlined interface allowing straight forward measurement set-up through analytical Workflows. The software includes auto-stop, standby modes, and other features to minimize intervention. It also allows for integrated data evaluation strategies, customized reports and method development. All of the auto-diagnostics ensure important aspects of the instrument are monitored, maximizing uptime.</p><p><strong>Thermo Scientific™ smartEA option:</strong> This option allows you to focus on your research by combining ease-of-use and unattended analysis to deliver high-precision results. The smartEA option uses the analyzer’s <strong>Thermal Conductivity Detector </strong>(TCD) trace to define the required sample dilutions in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2231"><strong>ConFlo IV Universal Interface</strong></a>. The straightforward automated workflow allows you to analyze very small amounts, such as nitrogen and sulfur, along with highly abundant elements, such as carbon - all from the same sample.</p><h3><strong>Addressing a world of applications</strong></h3><p><strong>For origin and authenticity questions, the EA IsoLink IRMS Platform provides precise and sensitive measurement of the isotope fingerprints - C, N, S, O and H isotopes - a unique chemical signature of samples, helping you gain unique insights into their history and origin.</strong></p><h4><strong>Food authenticity and origin</strong></h4><p><strong>Is the label declaration on my food correct?</strong></p><p>From fruits and vegetables, to wine, honey and coffee, the EA IsoLink IRMS Platform provides isotopic fingerprints ideally suited to determining food integrity.</p><ul><li>Food adulteration</li><li>Food and beverage origin</li><li>Agronomy</li></ul><h4><strong>Environmental</strong></h4><p><strong>What is the source of pollution in the soil, water or air?</strong></p><p>An assessment of individual organic pollutants particles in air contamination (e.g. PM2.5) will be traced with C, N, and S isotope fingerprints.</p><ul><li>Marine science</li><li>Ecology and biology</li><li>Petroleum and exploration</li></ul><h4><strong>Geosciences</strong></h4><p><strong>What was the weather like thousands of years ago?</strong></p><p>By analyzing materials such as sediments, ice cores and speleothems, researchers can understand epochal changes in vegetation, rainfall patterns and temperature.</p><ul><li>Soil science</li><li>Palaeoclimatology research</li></ul><h4><strong>Forensics</strong></h4><p><strong>How can we investigate provenance and dietary preferences?</strong></p><p>From tracing explosives, illegal drugs, counterfeit currency, animal tissues such as ivory, dietary preferences and crime scene evidence, forensic investigations based on isotope fingerprints examine samples’ origin.</p><ul><li>Archaeology</li><li>Provenance</li></ul><h3><strong>Connectivity for origin and authenticity</strong></h3><p>Your lab can focus on isotopic investigations by taking advantage of having one partner and one platform for your elemental and isotope analysis. Thanks to the connectivity of the<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2232"><strong>DELTA Q IRMS</strong></a> and the connecting peripherals that are fully controlled by the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>Qtegra ISDS Software</strong></a>, you can also leverage the high throughput, unattended operation and flexibility for demanding analysis, regardless of the applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_EA_Iso_Link_IRMS_System_2_dcb8a3d338.jpg" alt="Thermo Scientific™ EA IsoLink™ IRMS System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_EA_Iso_Link_IRMS_System_2_dcb8a3d338.jpg 245w," sizes="100vw" width="1464" height="933"></p>

Thermo Scientific Triton Series Multicollector Thermal Ionization Mass Spectrometer (TIMS)

High-precision multicollector TIMS for demanding isotope ratio analysis, delivering exceptional sensitivity, stability, and accuracy for ultra-small and low-abundance samples.

<p><strong>The Thermo Scientific™ Triton™ Series Multicollector Thermal Ionization Mass Spectrometer (TIMS) is a high-precision platform designed for the most demanding isotope ratio measurements. Built on more than two decades of continuous development, the Triton Series combines field-proven TIMS performance with state-of-the-art detection and ion-optical technologies to deliver exceptional accuracy, stability, and sensitivity—especially for small samples and low-abundance isotopes.</strong></p><p>At the heart of the Triton Series is a <strong>high-stability thermal ionization source</strong>, optimized for maximum ion transmission and minimal kinetic energy spread. This ensures highly reproducible ion beams for both single- and double-filament techniques, enabling precise isotope ratio analysis across a wide range of elements and applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Triton_Series_Multicollector_Thermal_Ionization_Mass_Spectrometer_TIMS_2_e9fa5e958e.jpg" alt="Thermo Scientific Triton Series Multicollector Thermal Ionization Mass Spectrometer (TIMS)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Triton_Series_Multicollector_Thermal_Ionization_Mass_Spectrometer_TIMS_2_e9fa5e958e.jpg 182w," sizes="100vw" width="650" height="558"></p><h3><strong>Advanced detection and ion optics</strong></h3><p>The Triton Series integrates multiple complementary detector technologies to address diverse analytical challenges:</p><ul><li><strong>10¹³ Ω Amplifier Technology</strong> extends the lower detection limits, delivering faster response times, extremely low noise, and significantly improved internal precision for small ion beams.</li><li><strong>Retarding Potential Quadrupole (RPQ) lenses</strong> provide exceptional abundance sensitivity by suppressing scattered ions and mass tailing, enabling accurate quantification of minor isotopes even next to intense ion beams.</li><li><strong>Multi Ion Counting (MIC) packages</strong> allow simultaneous detection of the lowest-intensity ion beams using SEM and CDD ion counters, with flexible configurations tailored to nuclear, geochronological, and geochemical applications.</li><li><strong>Stable, linear SEM and CDD ion counters</strong> ensure reliable measurements for ultra-low sample amounts and rare isotopes.</li><li><strong>High-performance Faraday cups</strong> guarantee uniform response, long operational lifetime, and excellent linearity for high-precision static and dynamic measurements.</li><li><strong>Movable multicollector array</strong> supports up to nine Faraday cups with precise alignment over a wide mass range, extendable to static Ca and Li isotope measurements.</li><li><strong>Virtual amplifier technology</strong> enables cancellation of gain factor uncertainties through amplifier rotation, achieving low-ppm external reproducibility in efficient static measurement modes.</li></ul><h3><strong>Designed for the most demanding isotope ratio applications</strong></h3><p>The Triton Series is ideally suited for applications where ultimate precision and high abundance sensitivity are essential, including:</p><ul><li>Radiogenic and stable isotope geochemistry</li><li>Geochronology (U–Pb, Pb–Pb, Rb–Sr, Sm–Nd, Lu–Hf systems)</li><li>Nuclear safeguards and nuclear forensic isotope analysis</li><li>Environmental and cosmochemical research</li><li>Analysis of ultra-small sample amounts and isotopically scarce materials</li></ul><p>Available in configurations such as <strong>Triton XT</strong> and <strong>Triton Plus</strong>, tailored to different performance priorities within high-precision isotope ratio analysis, the Thermo Scientific Triton Series TIMS offers a flexible, future-proof solution that continues to set the benchmark for thermal ionization mass spectrometry.</p>

Thermo Scientific ConFlo IV Universal Continuous Flow Interface

Universal continuous flow interface for IRMS enabling automated multi-device control, higher throughput, lower costs, and stable, unattended isotope analysis.

<p><strong>Thermo Scientific™ ConFlo IV Universal Continuous Flow Interface is a versatile continuous flow interface designed to significantly expand the application range of stable isotope laboratories using isotope ratio mass spectrometry (IRMS). The ConFlo IV system enables seamless connection of multiple sample preparation devices, delivering fully automated, stable, and highly reproducible measurements.</strong></p><p>The system features <strong>intelligent management of all required reference gases, automatic sample-size recognition, precise matching of sample and reference signals, and advanced self-diagnostics</strong>. These capabilities reduce operator involvement, lower operating costs, and increase overall laboratory throughput.</p><h3><strong>Key features</strong></h3><ul><li><strong>Management of multiple devices</strong><br>Automated switching between different sample preparation units, including activation, deactivation, and reference gas changes, maximizes IRMS utilization.</li><li><strong>Continuous, unattended operation</strong><br>Application switching can occur at any time without operator intervention; preparation devices can be regenerated and reloaded while other analyses are running.</li><li><strong>Maximized performance and efficiency</strong><br>Using reference gases instead of bulk reference materials reduces operating costs by nearly 50 % while increasing sample throughput by almost 50 %.</li><li><strong>Enhanced accuracy and stability</strong><br>Automatic adjustment of reference gas pulse intensities equalizes conditions between sample and reference gases, improving precision and long-term reliability.</li><li><strong>Advanced data quality control</strong><br>Critical system parameters affecting data quality are automatically monitored across all sample sequences.</li><li><strong>Single-interface control</strong><br>All connected preparation and inlet devices are controlled through one interface, with the ability to add new samples or entirely new applications without interrupting ongoing data acquisition.</li></ul>

Thermo Scientific DELTA Q Isotope Ratio Mass Spectrometer

High-performance IRMS combining exceptional sensitivity, robust design, and intuitive Qtegra ISDS software for food authenticity, environmental, forensic, and research isotope applications.

<p><strong>The Thermo Scientific™ DELTA™ Q Isotope Ratio Mass Spectrometer (IRMS) represents a new evolutionary step in isotope ratio analysis, combining outstanding analytical performance with intuitive operation powered by </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>Qtegra™ Intelligent Scientific Data Solution (ISDS)</strong></a><strong> software.&nbsp;</strong></p><p>The DELTA Q IRMS is designed for seamless integration with a wide range of Thermo Scientific peripherals, making it a highly flexible platform for applications such as <strong>food authenticity testing, environmental and forensic analysis, doping control, and advanced scientific research</strong>.</p><h4><strong>Outstanding sensitivity</strong></h4><ul><li>Sensitivities of up to <strong>800 molecules per CO₂ ion</strong> in dual-inlet mode and <strong>1,000 molecules per ion</strong> in continuous-flow mode.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DELTA_Q_Isotope_Ratio_Mass_Spectrometer_2_671e47510f.jpg" alt="Thermo Scientific DELTA Q Isotope Ratio Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DELTA_Q_Isotope_Ratio_Mass_Spectrometer_2_671e47510f.jpg 197w," sizes="100vw" width="650" height="517"></p><h4><strong>Versatility for diverse applications</strong></h4><ul><li>Support for up to <strong>10 collectors</strong> in multiple configurations, covering all IRMS applications up to <strong>m/z 96</strong>.</li><li><strong>Simultaneous mass range up to ±25%</strong>, enabling efficient multi-isotope measurements.</li><li>Compatibility with <strong>preconcentrators, elemental analyzers, GC interfaces, LC interfaces</strong>, and continuous-flow inlets.</li><li><strong>On-line H₂ capability</strong> for hydrogen isotope analysis.</li></ul><h4><strong>Highly robust and reliable design</strong></h4><ul><li>A <strong>monolithic analyzer</strong> with fixed alignment of all ion-optical components, including the electromagnet, ensuring exceptional long-term stability and robustness.</li><li>Integrated signal amplifiers and digitizers minimize external connections and increase reliability.</li><li>Fixed-position ion optics eliminate the need for realignment during installation or routine maintenance.</li><li>Optimized pumping strategy enables <strong>single-stage turbo pumping</strong> for all standard continuous-flow applications.</li><li>Comprehensive, automated diagnostics driven by <strong>Qtegra ISDS software</strong> support continuous performance monitoring.</li></ul><h4><strong>Compact and user-friendly design</strong></h4><ul><li>Compact footprint requiring minimal laboratory space.</li><li>Dedicated space for online peripherals on top of the instrument.</li><li>Dual inlet, µ-volume, and multiport interfaces are neatly integrated inside the system.</li><li>Continuous-flow interfaces can be fully controlled from the front panel.</li><li>All pumps are located internally, reducing noise and laboratory clutter.</li></ul><h4><strong>Qtegra™ ISDS Software</strong></h4><ul><li>Significantly increases laboratory productivity with <strong>automatic Get Ready functionality</strong>, ready-to-use templates, and built-in quality control tools.</li><li>Intelligent, optimized workflows guide users from sample to result while allowing flexible switching between system configurations.</li><li>Ensures full <strong>data integrity and traceability</strong> for raw data, metadata, and reported results.</li></ul><h4><strong>ACT label certification</strong></h4><p>The DELTA Q IRMS is certified with the <strong>ACT Environmental Impact Label</strong> from My Green Lab, providing transparent, third-party verified information on environmental impact across manufacturing, energy and water use, packaging, and end-of-life considerations—supporting sustainable laboratory procurement and reduced carbon footprint.</p>

Thermo Scientific Prima PRO Process Mass Spectrometer

Thermo Scientific™ Prima PRO is a highly reliable process analyzer designed for fast, precise multi-stream analysis in industrial processes. It delivers high analytical accuracy, stability, and robust performance in demanding process control applications.

<p><strong>The Thermo Scientific™ Prima PRO Process Mass Spectrometer is a highly reliable and versatile gas analyzer designed for fast, precise, multi-stream gas analysis in industrial process environments. Utilizing scanning magnetic sector technology, the system delivers superior analytical accuracy, long calibration intervals, and strong resistance to contamination. These capabilities make it suitable for demanding process control applications across the chemical, petrochemical, biotechnology, semiconductor, and steel industries.</strong></p><p>The integrated Rapid Multi-Stream Sampler (RMS) inlet system enables selection from up to <strong>127 process streams</strong>, allowing a single analyzer to replace multiple gas chromatographs while maintaining high sampling frequency. The intuitive touchscreen interface, configurable user permissions, and flexible model configurations support efficient operation, regulatory compliance, and scalable deployment across diverse industrial workflows.</p><h4><strong>Key features</strong></h4><ul><li><strong>High-precision scanning magnetic sector technology</strong> for real-time gas analysis</li><li><strong>Rapid Multi-Stream Sampling (RMS)</strong> system for up to 127 process streams</li><li><strong>Programmable analytical methods</strong> with universal detector capability</li><li><strong>Optional Variable Pressure Inlet</strong> (1000 mbar to 0.3 mbar) for flexible integration</li><li><strong>Intuitive touchscreen interface</strong> with real-time data visualization</li><li><strong>Advanced security </strong>with multi-role user permissions</li><li><strong>Scalable configurations</strong> for diverse industrial applications</li></ul><h4><strong>Technical specifications</strong></h4><ul><li><strong>Analysis time: </strong>0.3–1.0 s per gas component</li><li><strong>Analyzer type: </strong>Scanning laminated electromagnet, 6 cm radius, 80° deflection</li><li><strong>Area classification:</strong> ATEX / IECEx / UKEx Zone 1 and Zone 2 T3</li><li><strong>Detector: </strong>Faraday and optional Faraday/SEM dual detector</li><li><strong>Dynamic range: </strong>1 ppm – 100% (application dependent)</li><li><strong>Power: </strong>115/230 VAC</li><li><strong>Precision: </strong>Better than 0.1% relative over 24 h</li><li><strong>Resolution: </strong>Switchable collector slits; standard resolving powers 60 (1 mm) and 20 (4 mm); optional higher resolutions</li><li><strong>Stability:</strong> Better than 10% relative over one month</li><li><strong>User interface:&nbsp;</strong><ul style="list-style-type:circle;"><li><strong>Prima PRO 710:&nbsp;</strong>Color touchscreen GUI</li><li><strong>Prima PRO 700:&nbsp;</strong>None (remote operation)</li></ul></li><li><strong>Ambient temperature:</strong> 12–42 °C</li><li><strong>Mass range:</strong> 1–200 amu</li></ul>

Thermo Scientific™ Prima BT Bench Top Process Mass Spectrometer

Achieve high scanning speeds and reproducible measurements with the Thermo Scientific™ Prima BT Bench Top Mass Spectrometer.

<div><div><p><strong>Achieve high scanning speeds and reproducible measurements with the Thermo Scientific™ Prima BT Bench Top Process Mass Spectrometer. Specifically designed for process development laboratories, this real-time process gas analyzer is a highly precise, multi-port magnetic sector analyzer.</strong></p></div><div><p>The <strong>Prima BT Process Mass Spectrometer</strong> offers robust performance in the presence of off-gases and vapors that have the potential to contaminate internal vacuum components. As the ions are extracted from the ion source at high energy, excellent stability is achieved for low molecular weight compounds such as hydrogen and helium.</p><h4><strong>✔️ Key Features</strong></h4><ul><li>Scanning magnetic-sector technology</li><li>16-port Rapid Multistream Sampler (RMS)</li><li>Six-port automatic calibration manifold</li><li>High analytical precision, accuracy and stability</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/pharma-biopharma/manufacturing-control-pharma-biopharma/process-analytical-technology/gasworks-process-analysis-software.html">Thermo Scientific™ GasWorks Software</a></li></ul><h4><strong>Warranty and Service Offering</strong></h4><p>To maintain optimal product performance, you need immediate access to experts worldwide, as well as priority status when your analyzer needs repair or replacement. We offer <strong>comprehensive, flexible support solutions </strong>for all phases of the product life cycle. Through <strong>predictable, fixed-cost pricing</strong>, our services help protect the return on investment and total cost of ownership of your Thermo Scientific products.</p></div><div><p>The <strong>Thermo Scientific Prima BT Bench top Mass Spectrometer </strong>is an industrial laboratory gas analyzer based on scanning magnetic-sector mass spectrometry. Designed for continuous operation in a laboratory environment, the Prima BT mass spectrometer is simple to operate and easy to maintain.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Prima_BT_procesni_MS_pro_analyzu_plynu_1_b38b34871c/Thermo-Prima-BT-procesni-MS-pro-analyzu-plynu-1.jpg" alt="Thermo Scientific™ Prima BT Bench Top Process Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Prima_BT_procesni_MS_pro_analyzu_plynu_1_b38b34871c/thumbnail_Thermo-Prima-BT-procesni-MS-pro-analyzu-plynu-1.jpg 199w," sizes="100vw" width="927" height="726"></p><h3><span><strong>⚙️ Specifications</strong></span></h3><ul><li><strong>Analysis Time:</strong> 0.3 to 1.0 sec. per gas component</li><li><strong>Analyzer Type:</strong> Scanning Magnetic Sector Mass Spectrometer with Enclosed Electron Impact Dual Filament Ion Source</li><li><strong>Area Classification Options:</strong> General Purpose</li><li><strong>Depth (English):</strong> 1.8 ft.</li><li><strong>Depth (Metric):</strong> 0.56 m</li><li><strong>Dynamic Range:</strong> Faraday: 10 ppm to 100 ppm</li><li><strong>Dynamic Range (optional):</strong> Single MCP SEM: 1 ppm to 1000 ppm; Twin MCP SEM: 10 ppb to 1000 ppm</li><li><strong>Height (English):</strong> 1.7 ft.</li><li><strong>Height (Metric):</strong> 0.53 m</li><li><strong>No. of Calibration Gas Inlets:</strong> Up to 6</li><li><strong>No. of Sample Stream Inlets:</strong> Up to 15</li><li><strong>Power:</strong> 115/230 V, Consumption: 1.5 kVA</li><li><strong>Precision:</strong> ≤ 0.1% relative</li><li><strong>Stability:</strong> ≤ 1% relative over one week</li><li><strong>Weight (English):</strong> 220 lb., Additional floor mounting rotary pump: 66 lb.</li><li><strong>Weight (Metric):</strong> 100 kg, Additional floor mounting rotary pump: 30 kg</li><li><strong>Width (English):</strong> 2.8 ft.</li><li><strong>Width (Metric):</strong> 0.86 m</li><li><strong>Ambient Temperature:</strong> 12 °C to 30 °C</li><li><strong>Communication Protocols:</strong> Modbus serial RS232/422/485, Siemens 3964R, VGCP and PVGCP</li><li><strong>Mass Range:</strong> Adjustable, 1 to 150 amu at 1000 eV ion acceleration voltage, 1 to 200 amu at 750 eV ion acceleration voltage</li><li><strong>Product Type:</strong> Prima BT Bench Top Process Gas Analysis Mass Spectrometer</li><li><strong>Unit Size:</strong> Each</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Prima_BT_procesni_MS_pro_analyzu_plynu_2_b4a02abf9d/Thermo-Prima-BT-procesni-MS-pro-analyzu-plynu-2.jpg" alt="Thermo Scientific™ Prima BT Bench Top Process Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Prima_BT_procesni_MS_pro_analyzu_plynu_2_b4a02abf9d/thumbnail_Thermo-Prima-BT-procesni-MS-pro-analyzu-plynu-2.jpg 166w," sizes="100vw" width="1269" height="1189"></p></div></div>

Thermo Scientific Orbitrap™ Exploris™ GC Mass Spectrometer

Transform your data quality to deliver the right answer first time, every time with the Thermo Scientific™ Orbitrap™ Exploris™ GC Mass Spectrometer.

<div><div id="product-description"><strong>Simplify operations and deliver consistently accurate results in analytical testing using the Thermo Scientific™ Orbitrap™ Exploris™ GC Mass Spectrometer. This GC-MS system offers a unique depth of analysis and unparalleled accuracy and precision to improve everyday quantitation, screening and sample profiling. It provides the flexibility to keep pace with ever-changing regulations and explore new analytical opportunities through increased scope and method consolidation. Simple instrument set up and intelligent informatics enable users of all abilities to easily access data-rich information.</strong></div><div><h4><strong>Deliver accurate quantitative results and spend less time reviewing data in high throughput analytical testing</strong></h4><ul><li>Offers the power and flexibility of full-scan high-resolution accurate mass data to quantitative, screening and discovery workflows</li><li>Accelerates data reviewing with multi-point compound identification, including spectral matching, isotope pattern match, retention indices and multiple confirmation ions</li></ul><h4><strong>Be one step ahead of changing demands</strong></h4><ul><li>Provides the flexibility to keep pace with ever-changing regulations and enables you to explore new business opportunities through increased scope and method consolidation</li><li>Offers the option to configure the system with either 30,000 or 60,000 mass resolving power and the ability to add MS/MS capability today or in the future</li></ul><h4><strong>Focus on results, not instrument setup</strong></h4><ul><li>Simple instrument set up and intelligent informatics enable users of all abilities to easily access data-rich information</li><li>Next-generation software, including built-in method templates, provides easy-to-use and flexible options that are fully accessible to all members of the analytical team</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_GC_Mass_Spectrometer_337a570de7.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Orbitrap™ Exploris™ GC Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_GC_Mass_Spectrometer_337a570de7.jpg 245w," sizes="100vw" width="1032" height="617"></p><h4><strong>Benefits that boost productivity</strong></h4><h5><strong>Increase scope</strong></h5><p>Gain the flexibility to quickly add new compounds without compound optimization and decide post acquisition which analytes to measure.</p><h5><strong>Fast system setup</strong></h5><p>Walk up, tune, and calibrate in under five minutes with full confidence that the system is operating at maximum performance for all users.</p><h5><strong>Efficient review and reporting</strong></h5><p>Use multiple points of identification to quickly confirm or reject detections, increasing peace of mind. Spectral matching, isotope patterns, retention indices, and elemental compositions provide high confidence in results.</p><h5><strong>Accurate quantitation</strong></h5><p>Six orders of linear dynamic range covers the concentrations encountered in even the most complex sample matrices.</p><h5><strong>Method consolidation</strong></h5><p>Combine acquisition methods onto a single system, reducing the need for multiple systems and streamlining data processing.</p><h5><strong>Retrospective analysis</strong></h5><p>Interrogate previously acquired high-resolution accurate-mass (HRAM) data in multiple ways to answer additional analytical questions without additional sample injections.</p><h4><strong>Power GC-MS with Thermo Scientific software solutions</strong></h4><ul><li><strong>Chromeleon CDS:</strong> Enterprise-ready, regulatory-compliant quantitation</li><li><strong>TraceFinder software:</strong> High-throughput screening and quantitation</li><li><strong>Compound Discoverer software:</strong> Small-molecule unknown identification</li></ul><h3><strong>Specifications</strong></h3><ul><li><strong>Dynamic Range:</strong> &gt;5000 within a single Orbitrap mass analyzer spectrum</li><li><strong>Mass Range: </strong>30 to 3000 m/z</li><li><strong>Mass Accuracy: </strong>External calibration achieves &lt;3 ppm RMS drift over 24 hours, Internal lock mass calibration achieves &lt;1 ppm RMS drift over 24 hours</li><li><strong>Resolution: </strong>Up to 60,000 at m/z 200</li><li><strong>Scan Rates: </strong>Up to 40 Hz at resolution setting 7,500 at m/z 200</li><li><strong>Description:</strong> Orbitrap Exploris GC Mass Spectrometer, no MS/MS</li></ul></div></div>

Thermo Scientific™ Orbitrap™ Exploris™ GC 240 Mass Spectrometer

Take research capability to a new, unprecedented level of performance with the Thermo Scientific™ Orbitrap Exploris™ GC 240 mass spectrometer and accelerate your scientific discovery. 

<p><strong>Simplify the most complex analytical challenges and achieve excellent data quality with the Thermo Scientific™ Orbitrap™ Exploris™ GC 240 mass spectrometer.&nbsp;</strong></p><p>By delivering <strong>uncompromising qualitative and quantitative information</strong>, this <strong>high-resolution accurate-mass GC-MS system</strong> addresses the evolving requirements of research laboratories for <strong>compound identification and quantitation</strong>. From <strong>discovery profiling</strong>, <strong>metabolomics</strong> and <strong>applied quantification</strong>, scientists gain <strong>unparalleled access to information-rich data and results</strong>.</p><p><strong>Experience breakthrough performance in high resolution GC-MS analysis</strong> to gain the <strong>deepest insights</strong> into your sample.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Orbitrap_Exploris_GC_240_Mass_Spectrometer_1_99d830b929/Thermo-Orbitrap-Exploris-GC-240-Mass-Spectrometer-1.jpg" alt="Thermo Scientific™ Orbitrap™ Exploris™ GC 240 Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Orbitrap_Exploris_GC_240_Mass_Spectrometer_1_99d830b929/thumbnail_Thermo-Orbitrap-Exploris-GC-240-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></p><h5><strong>The Orbitrap Exploris GC 240 mass spectrometer:</strong></h5><ul><li><strong>Enables you to get the right answer first time</strong></li><li><strong>Offers the flexibility to adapt to ever-changing needs</strong> with its <strong>superior mass accuracy, dynamic range and robustness</strong></li><li><strong>Includes intelligent instrument setup and an intuitive user experience</strong> to make it fully accessible for users of all skill levels</li><li><strong>Offers unprecedented 240,000 resolution (at m/z 200)</strong> to deliver <strong>sub-1-ppm mass accuracy</strong> and <strong>sensitivity down to part-per-trillion concentrations</strong></li><li><strong>Maintains system sensitivity at all mass resolution levels</strong>, so there is <strong>no need to compromise between resolution and sensitivity</strong></li><li><strong>Features repeatable performance injection after injection</strong> to enable discoveries to be made across <strong>high sample studies</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Orbitrap_Exploris_GC_240_Mass_Spectrometer_2_8a411289bf/Thermo-Orbitrap-Exploris-GC-240-Mass-Spectrometer-2.jpg" alt="Thermo Scientific™ Orbitrap™ Exploris™ GC 240 Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Orbitrap_Exploris_GC_240_Mass_Spectrometer_2_8a411289bf/thumbnail_Thermo-Orbitrap-Exploris-GC-240-Mass-Spectrometer-2.jpg 156w," sizes="100vw" width="650" height="650"></p><h3><strong>Thermo Scientific™ Orbitrap™ Exploris™ GC 240 Mass Spectrometer Specifications</strong></h3><ul><li><strong>Description:</strong> Orbitrap Exploris GC 240 Mass Spectrometer</li><li><strong>Dynamic Range:</strong> &gt;5000 within a single Orbitrap mass analyzer spectrum</li><li><strong>Mass Accuracy:</strong> External calibration achieves &lt;3 ppm RMS drift over 24 hours, Internal lock mass calibration achieves &lt;1 ppm RMS drift over 24 hours.</li><li><strong>Scan Rates:</strong> Up to 40 Hz at resolution setting 7,500 at m/z 200</li><li><strong>Mass Range:</strong> 30 to 3000 m/z</li><li><strong>Resolution:</strong> Up to 240,000 at m/z 200</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific ISQ™ 7610 Single Quadrupole GC-MS

Thermo Scientific ISQ™ 7610 Single Quadrupole GC-MS. Simplified operation, automated workflows, and extended dynamic range deliver consistent results from system to system in every laboratory.

<p><strong>To stay ahead, analytical testing laboratories need the ultimate confidence of a GC-MS system that easily and reliably produces trusted results, day after day. For this, you can count on the Thermo Scientific™ ISQ™ 7610 Single Quadrupole GC-MS System. Simplified operation, automated workflows, and extended dynamic range deliver consistent results from system to system in every laboratory. Thermo Scientific™ NeverVent™ technology, extended-life detector, and intelligent software eliminate unnecessary downtime to maximize sample throughput. To ensure you are ready for any analytical challenge, the system is upgradeable from entry-level to advanced configurations. Now you can take the lead with rapid return on investment (ROI) for your regulated GC-MS analyses.</strong></p><h4><strong>Unstoppable confidence in quantitative performance</strong></h4><p>Delivers femtogram-level sensitivity so you consistently meet required detection limits as you run samples, whether you run in SIM mode or Full Scan. The ISQ 7610 GC-MS features a unique ion path that neutral particles cannot navigate and a choice of an ExtractaBrite or AEI ion source, depending on your sensitivity needs. The instrument’s XLXR detector which is an electron multiplier detector has an extended lifetime and extended dynamic range. Extended dynamic range capability enables labs to combine methods allowing analysis of low- and high-concentration compounds in a single run.</p><h4><strong>The right choice for any workflow</strong></h4><p>The intuitive <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/chromatography/chromatography-data-systems-cds.html">Thermo Scientific Chromeleon Chromatography Data System (CDS)</a> is available to help streamline quantitative workflows and ready-to-use Thermo Scientific eWorkflows can be downloaded from the <a target="_blank" rel="noopener noreferrer" href="https://appslab.thermofisher.com/">Thermo Scientific Appslab Library of Analytical Applications</a> to jump-start your method development. For U.S. EPA-based environmental applications, the Environmental Analysis Extension pack provides a set of GC-MS e-workflow and reporting templates.</p><h4><strong>Unstoppable instrument uptime for full-time productivity</strong></h4><p>The robust design of the ISQ 7610 GC-MS ensures that the system can work continuously to produce the highest quality results possible. High matrix tolerance minimizes routine maintenance, but when maintenance is required, the NeverVent technology available with the ExtractaBrite ion source enables source cleaning, column replacement or injector maintenance without requiring downtime to vent the instrument, so more time can be spent producing results.</p><h4><strong>Ease of use that helps you stay ahead</strong></h4><p>Automated software for instrument tuning, method development, targeted quantification and untargeted screening workflows make the ISQ 7610 GC-MS system easy to learn and enables quick transition to this system from other platforms. The ISQ 7610 Single Quadrupole GC-MS System features user-centric innovations including instrument health monitoring assists you in determining when maintenance is needed to avoid unnecessary downtime. As a result, you maximize instrument utilization, sample throughput, and ultimately ROI.</p><h4><strong>Unstoppable confidence in your future</strong></h4><p>To ensure you are ready for any analytical challenge, the ISQ 7610 Single Quadrupole GC-MS System is fully upgradable from entry-level to advanced configurations. Now you can be confident that your laboratory can adapt to new challenges using the same investments in GC-MS technology.</p><h3><span><strong>Specifications</strong></span></h3><ul><li><span><strong>Mass Range: </strong>1.2–1100 u with unit mass resolution&nbsp;</span></li><li><span><strong>Type:&nbsp;</strong>Single Quadrupole GC-MS</span></li><li><span><strong>Detectors:&nbsp;</strong>Triple off-axis Thermo Scientific™ DynaMax™ XTEND XR detection system, with off-axis 10 kV dynode, discrete dynode electron multiplier and electrometer, linear from 0 to 110 μA</span></li><li><span><strong>Modes:&nbsp;</strong>Electron Impact Ionization (EI), with Full Scan (FS), SIM, and FS/SIM, Simultaneous within the same injection</span></li><li><span><strong>Scanning Capabilities:&nbsp;</strong>Fast Quadrupole Scanning up to 20,000 U/s</span></li><li><span><strong>Source Type:</strong>&nbsp;Advanced Electron Ionization (AEI) Source for Ultra-Sensitivity and Robustness</span></li><li><span><strong>Item Description:&nbsp;</strong>Scalable GC-MS platform, fully upgradable from a base configuration to an advanced highly sensitive configuration</span></li><li><span><strong>Description:</strong>&nbsp;ISQ 7610 Large Turbo, No VPI with AEI</span></li><li><span><strong>Mass Stability:&nbsp;</strong>Better than 0.1 u/48 hours/∆T ≤2 K</span></li><li><span><strong>Dimensions:</strong>&nbsp;46 x 36 x 69 cm (18 x 14 x 27 in) (H x W x D)</span></li><li><span><strong>Mass Analyzer:&nbsp;</strong>Dual-stage mass filter with off-axis ion guide pre-filter for noise reduction and solid, homogeneous non- coated, maintenance-free quadrupole rods</span></li></ul>

Thermo Scientific TSQ 9610 Triple Quadrupole GC-MS

The Thermo Scientific TSQ 9610 triple quadrupole GC-MS/MS systems is the best-in-class system for ultimate sensitivity and quantitation of targeted compounds. Optimized for high-throughput analytical laboratories.

<div><div id="product-description"><p><strong>To confidently stay ahead, your GC-MS/MS system must deliver ultimate performance while consistently producing trusted quantitative results. For this, turn to the Thermo Scientific™ TSQ™ 9610 Triple Quadrupole GC-MS/MS System. User-centric Thermo Scientific™ NeverVent™ technology, extended-life detector, and intelligent software eliminate unnecessary downtime to maximize your sample throughput and return on investment (ROI). New extended linear dynamic range combined with proven high sensitivity ensures you keep ahead of the toughest regulatory methods and business demands.</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/gas-chromatography-mass-spectrometry-gc-ms/gc-ms-systems/triple-quadrupole-gc-ms.html"><strong>Discover TSQ 9610 GC-MS highlights</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/store/instruments/configurators/trace1600"><strong>Build your GC-MS system</strong></a></li></ul></div><div><h4><strong>Increase instrument uptime</strong></h4><p>Eliminate unnecessary, unplanned instrument downtime to deliver high-confidence quantitative results, day after day. The TSQ 9610 Triple Quadrupole GC-MS/MS System combines unstoppable robustness with the ability to change the GC column and clean the ion source without interrupting analytical workflows.<br><br>Monitor key aspects of your GC-MS system. With Thermo Scientific™ SmartStatus™ instrument tracking within Chromeleon CDS, quickly see whether instruments are ready to run samples, if maintenance is required or if consumables should be replaced. The fully customizable software enables you to make data-driven decisions on when to perform maintenance and avoid unnecessary downtime.</p><h4><strong>Maximize sample throughput</strong></h4><p>When high sample throughput is essential, the system delivers results on time and with ease. Automated workflows and simplified operation ensure every user produces consistent results, sample after sample. Extended linear range and rapid selected reaction monitoring (SRM) scanning enable method consolidation so you can analyze more compounds in a single run. When these capabilities are combined with best-in-class uptime and sensitivity, you stay ahead of any productivity demand.</p><h4><strong>Realize rapid return on investment&nbsp;</strong></h4><p>Ensuring your system delivers results as soon as it’s installed is necessary to achieve rapid ROI. With built-in intelligence that simplifies instrument setup, analytical methods, and everyday operation, the TSQ 9610 Triple Quadrupole GC-MS/MS System is designed for accelerated deployment. Reduced needs for operator training and faster time to full productivity together with maximum sample throughput provide fast return on your instrument</p><h3><strong>TSQ 9610 GC-MS/MS highlights</strong></h3><h4><strong>Unstoppable confidence in quantitative performance</strong></h4><p>Delivering attogram-level sensitivity and best-in-class selected reaction monitoring (SRM) performance, the TSQ 9610 GC‑MS/MS system consistently meets required detection limits as you run samples. Choose the rugged Thermo Scientific ExtractaBrite ion source or the ultra-sensitive, ultra-robust Thermo Scientific Advanced Electron Ionization (AEI) ion source, depending on your sensitivity needs.</p><p>The XLXR electron multiplier detector which extends dynamic range twofold compared to the previous design. Extended dynamic range capability enables labs to combine methods, including calibration curve development, allowing analysis of low- and high-concentration compounds in a single run.</p><div container-id="cq-colctrl-lt0" comp-id="A2"><div><h4><strong>Unstoppable confidence in uptime for full-time productivity</strong></h4><p>The TSQ 9610 GC-MS/MS system is specifically designed for complex sample matrices in high-throughput applications.&nbsp;Using NeverVent technology with the Vacuum Probe Interlock (VPI) and V-Lock source plug, planned maintenance such as changing column and ion source cleaning can be performed without venting the mass spectrometer, increasing uptime. NeverVent technology is available on both the Thermo Scientific ExtractaBrite and the Thermo Scientific NeverVent Advanced Electron Ionization (NV-AEI) sources.</p></div></div><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h4><strong>Unstoppable confidence in your investment</strong></h4><p>Rapid instrument deployment reduces time to results and revenue generation. That’s why the TSQ 9610 Triple Quadrupole GC-MS/MS System includes a comprehensive set of automated tools to provide users with a seamless experience when transitioning from other platforms, developing methods, and analyzing samples. This built-in intelligence reduces operator training needs and time to full productivity for rapid ROI.</p></div></div></div><h4><strong>Unstoppable confidence in sample throughput</strong></h4><p>Maximizing sample throughput is essential to producing results on time. The TSQ 9610 Triple Quadrupole GC-MS/MS System incorporates user-centric innovations that extend service intervals, reduce maintenance, and allow methods consolidation to boost sample throughput while maintaining certainty in quality of results.</p></div></div>

Products focused on GC/MSD distributed by Thermo Fisher Scientific (EMEA) - page 1

Related content

Quantitative Assessment of Chemical Modifications of Macromolecules through Counterion Measurement

Is Curzerene Responsible for the Bioactive Properties of Eugenia uniflora? A Possible Misinterpretation of Bioactive Markers

Regulated Drinking Water Testing: PFAS Detection, Sample Prep & Real Lab Insights