<div><p><strong>In 2025, two outstanding young female researchers, Drs. Filipa Oliveira and Stella Gonsales, both originally from outside the Czech Republic, received prestigious JUNIOR STAR grants from the Czech Science Foundation (GAČR). JUNIOR STAR enables early career researchers to establish their own independent research groups and significantly advance their scientific careers. Their projects reflect cutting-edge research in materials science and sustainable chemistry, highlighting the international reach and welcoming research environment at UCT Prague.</strong></p><p><strong>Dr. Stella Gonsales is also a&nbsp;laureate of the Dagmar Procházková Fund, which supports promising scientific projects in sustainable and advanced organic chemistry. Another recipient of this grant is Dr.&nbsp;Anna Valunchene, whose research complements UCT Prague’s&nbsp;sustainability goals. This dual funding underlines Stella’s&nbsp;remarkable achievements and the wide scope of innovative research at UCT Prague.</strong></p><p><strong>Both Filipa and Stella are actively looking for motivated students and researchers to join their teams, offering a&nbsp;unique opportunity to work at the forefront of science in a&nbsp;vibrant and supportive environment.</strong></p></div><div><h3><strong>Interview with Filipa Oliveira: Pioneering tubular MXenes for supercapacitor energy storage</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_2_da6e538579.jpeg" alt="VŠCHT Prague: JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science: Filipa Oliveira" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_2_da6e538579.jpeg 235w," sizes="100vw" width="1500" height="999"></p><h5><strong>Congratulations on receiving the JUNIOR STAR grant. What does this achievement mean for you and how will it influence your next steps?</strong></h5><p>Thank you. It’s&nbsp;a huge achievement to receive this prestigious grant. It gives me the opportunity to establish my own research group here at UCT Prague. The JUNIOR STAR program supports talented young scientists in building their teams and accessing resources. This means I&nbsp;now have the support to focus fully on my research about tubular MXenes and their application in supercapacitors.</p><h5><strong>Why are tubular MXenes so innovative for energy storage?</strong></h5><p>MXenes are a family of 2D materials with a layered, accordion-like structure and known for their excellent electrical conductivity. Our innovation is to produce them with a tubular morphology, combining the high conductivity and redox activity in superior ion-transport tubular architectures. Their open, hollow structure increases surface area, ion diffusion and charge transport. This could translate to faster, more efficient supercapacitors, critical for sustainable energy technologies.</p><h5><strong>How did your scientific interest lead you to this field?</strong></h5><p>Global challenges around green energy made me focus on materials that can improve energy storage. MXenes stood out because changes in the composition and structure can significantly change their properties. I&nbsp;was curious about how tuning different metallic elements in a&nbsp;tubular morphology can impact how MXenes perform and how to optimize them for practical applications.</p><h5><strong>What challenges have you encountered?</strong></h5><p>One major challenge is their stability: MXenes oxidize quickly which deteriorates performance. Another challenge is understanding how synthesis conditions of both MXenes and their precursors (MAX phases) must be adapted to create and preserve tubular morphologies since their synthesis mechanisms differ from conventional MXenes. Additionally, effectively communicating the project in the funding proposal to show to reviewers why I&nbsp;should obtain this funding was also a&nbsp;challenge, but thanks to mentorship and collaboration, I&nbsp;overcame these hurdles.</p><h5><strong>What motivates you most about working at UCT Prague?</strong></h5><p>The support from colleagues and the excellent technical infrastructure make it a&nbsp;great place to work. Also, being a&nbsp;former member of Professor Sofer’s&nbsp;leading group in 2D&nbsp;materials is inspiring and led me to this achievement.</p><h5><strong>How do&nbsp;you see your professional development going in the future?</strong></h5><p>The grant will help me build my own team, acquire equipment, and develop collaborations. My long-term vision is to contribute significantly to sustainable energy solutions and scientific progress both locally and internationally.</p><h5><strong>You are looking for new team members. What kind of students or scientists do&nbsp;you need?</strong></h5><p>We are currently welcoming enthusiastic master's&nbsp;students, PhD candidates, and postdocs who are passionate about materials science and eager to explore new frontiers in MXenes and energy storage. If you love curiosity-driven research and want to be part of a&nbsp;growing international team, we encourage you to join us.</p><h3><strong>Interview with Stella Gonsales: Catalysis as a&nbsp;key to polymer recycling</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_3_3d0ded6274.jpeg" alt="VŠCHT Prague: JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science: Stella Gonsales" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_VSCHT_Praha_V_prestizni_soutezi_GACR_uspely_dve_zahranicni_vedkyne_z_VSCHT_3_3d0ded6274.jpeg 233w," sizes="100vw" width="1499" height="1000"></p><h5><strong>Congratulations on your JUNIOR STAR grant and also being awarded the Dagmar Procházková Fund. What does receiving both mean to you and how will they shape your work?</strong></h5><p>Thank you. Both grants are hugely important. The JUNIOR STAR grant allows me to expand my group and resources for research into catalytic recycling of polymers, while the Dagmar Procházková Fund supports complementary projects such as synthesizing new biodegradable polymers. Together, they help tackle the plastic waste problem from multiple scientific angles.</p><h5><strong>Could you explain your research in layperson’s&nbsp;terms?</strong></h5><p>Most plastics have strong carbon-carbon bonds. We insert more cleavable double bonds into polymers that can be broken down by catalytic reactions called olefin metathesis, making recycling on a&nbsp;molecular level more feasible.</p><h5><strong>What makes the JUNIOR STAR grant particularly important for your research and career development?</strong></h5><p>The JUNIOR STAR grant is a&nbsp;prestigious and highly competitive funding opportunity aimed at excellent early-career scientists within eight years of completing a&nbsp;Ph.D. It provides up to 25&nbsp;million CZK over five years, allowing recipients to establish independent research groups and pursue innovative scientific topics. This grant is crucial for building a&nbsp;solid foundation, acquiring necessary equipment, and recruiting talented team members, enabling the pursuit of ambitious projects that can significantly contribute to both the Czech scientific community and global challenges.</p><h5><strong>What collaborations support your research?</strong></h5><p>The collaboration between UCT Prague and the Institute of Organic Chemistry and Biochemistry (IOCB) of the Czech Academy of Sciences primarily provides financial and technical support. The cooperation helps with funding, access to advanced equipment, and operational resources needed for running research projects.</p><h5><strong>What advice would you give young scientists aiming to succeed?</strong></h5><p>I&nbsp;encourage thinking outside the box and combining diverse knowledge you acquire during your career to address complex problems that are exciting and relevant to you.</p><h5><strong>Your laboratory bears the name of Otto Wichterle and was ceremonially opened in the presence of Professor Kamil Wichterle. How does Wichterle’s&nbsp;legacy inspire you personally?</strong></h5><p>Wichterle’<s>’</s>s&nbsp;innovative spirit motivates me to push creative boundaries and pursue novel solutions in sustainable chemistry.</p><h5><strong>What are your visions for the future?</strong></h5><p>I&nbsp;aim to build a&nbsp;research group that advances sustainable polymer recycling, contributing to environmental responsibility and the circular economy.</p><h5><strong>You are recruiting people for your team. What skills do&nbsp;they need to have?</strong></h5><p>We are looking for talented Ph.D. students and postdocs experienced in air-sensitive catalysis techniques. If you want to contribute to transformative research in sustainable chemistry and join a&nbsp;dynamic team, this is a&nbsp;great opportunity.</p></div>

JUNIOR STAR Grants at UCT Prague: Two talented women from abroad driving innovation in science

News from LabRulezGCMS Library - Week 06, 2026

<p><strong>Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from deoxyribonucleic acid (DNA) into ribonucleic acid (RNA) can be initiated. The researchers focused on a specific class of molecules known as alarmones, which are found in cells across a wide range of organisms and whose levels often increase under conditions of cellular stress. The results were published in the prestigious scientific journal </strong><i><strong>Nature Chemical Biology</strong></i><strong>.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Hana Cahová, head of the Chemical Biology of Nucleic Acids research group." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Molecules of ribonucleic acid can carry a variety of chemical modifications at one end, known as caps. In eukaryotic organisms, including human cells, the best-known cap plays an important role in RNA stability and in regulating its subsequent fate. In recent years, however, it has become clear that alternative, non-canonical RNA caps also exist, although their formation and the mechanisms by which they are attached to RNA remain only partially understood. These include alarmone caps, formed by dinucleoside polyphosphate molecules, that protect cellular RNA at moments when the cell is under threat.</p><p>In their study,<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://cahova.group.uochb.cz/en"><strong>Dr. Hana Cahová</strong></a> and colleagues examined bacterial RNA polymerase and investigated how this enzyme can initiate transcription using dinucleoside polyphosphates (NpNs) instead of the standard RNA building blocks. For the first time, the scientists described, at the atomic level, how RNA bearing an alarmone cap can be generated directly at the initiation of gene transcription. They also observed that NpNs bind through a different type of base pairing than is typically observed.</p><p>The work was significantly shaped by <strong>Valentina Serianni from Hana Cahová’s team</strong>, who demonstrated the ability of dinucleoside polyphosphates to initiate gene transcription, and by <strong>Jana Škerlová</strong>, who focused on the structural analysis of RNA polymerase. Using cryogenic electron microscopy data, she showed how dinucleoside polyphosphate molecules bind within the active site of RNA polymerase – that is, the core of the enzyme where genetic information is transcribed. Together, their findings help to elucidate the processes that accompany the transcription of genetic information from DNA to RNA.</p><p>Hana Cahová adds: <i>“We’re describing something that truly occurs in cells and that we’re now able to observe directly at the level of individual molecules. This allows us to answer fundamental questions about cellular processes, such as how cells adapt to stress. RNA plays a central role in this, as it carries the cascade of information underlying any cellular response – for example, to threatening conditions caused by nutrient deprivation or temperature shock.”</i></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Tomáš Kouba, head of the Cryogenic Electron Microscopy core facility." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Cryogenic electron microscopy (cryo-EM) was central to the project. This part of the work was led by<strong> Dr. Tomáš Kouba</strong>, one of the authors of the study. <i>“Cryogenic electron microscopy allows us to freeze biological molecules in a state very close to their natural form and then determine their three-dimensional structure. This makes it possible to look directly into the active centers of enzymes and observe their function down to the atomic level,”</i> he explains.</p><p>Last year, IOCB Prague opened a new <a target="_blank" rel="noopener noreferrer" href="https://cryoem.group.uochb.cz/en"><strong>cryo-EM center</strong></a><strong> </strong>that is unique within the Czech research environment. State-of-the-art cryogenic electron microscopes are housed in a specially designed building and enable the study of biological processes with exceptional structural precision.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg" alt="IOCB Prague: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: This work shows how NpnNs initiate bacterial transcription. Cryo-EM reveals how nucleobases pair with the template: one in canonical and one in reverse Watson–Crick mode, providing a structural basis for their function as non-canonical RNA caps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg 245w," sizes="100vw" width="2000" height="1077"></p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-025-02134-5"><strong>Molecular insight into 5′ RNA capping with Np<sub>n</sub>Ns by bacterial RNA polymerase</strong></a></h4><p>Valentina M. Serianni, Jana Škerlová, Anna Knopp Dubánková, Anton Škríba, Hana Šváchová, Tereza Vučková, Anatolij Filimoněnko, Milan Fábry, Pavlína Řezáčová, Tomáš Kouba &amp; Hana Cahova&nbsp;</p><p>Nat. Chem. Biol. 21 (2026)</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-025-02134-5">https://doi.org/10.1038/s41589-025-02134-5</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>RNA capped with dinucleoside polyphosphates has been discovered in bacteria and eukaryotes only recently. The likely mechanism of this specific capping involves direct incorporation of dinucleoside polyphosphates by RNA polymerase as noncanonical initiating nucleotides. However, how these compounds bind into the active site of RNA polymerase during transcription initiation is unknown. Here, we explored transcription initiation in vitro, using a series of DNA templates in combination with dinucleoside polyphosphates and model RNA polymerase from <i>Thermus</i> <i>thermophilus</i>. We observed that the transcription start site can vary on the basis of the compatibility of the specific template and dinucleoside polyphosphate. Cryo-electron microscopy structures of transcription initiation complexes with dinucleoside polyphosphates revealed that both nucleobase moieties can pair with the DNA template. The first encoded nucleotide pairs in a canonical Watson–Crick manner, whereas the second nucleobase pairs noncanonically in a reverse Watson–Crick manner. Our work provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription.</p></div></div>

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

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The University of Chemistry and Technology, Prague is a natural centre of first-rate study and research in the area of chemistry in Czechia and is one of the country's largest educational and research institutions focused on technical chemistry, chemical and biochemical technologies, material and chemical engineering, food chemistry, and environmental studies.

UCT Prague

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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Organomation MICROVAP Triple Microplate Evaporator

The triple plate MICROVAP microplate evaporator combines three 96 needle manifolds and three heat blocks into a single platform.

<p><strong>The triple plate MICROVAP microplate evaporator combines three 96 needle manifolds and three heat blocks into a single platform. This allows for simultaneous evaporation of up to three 96 well plates. The triple plate MICROVAP’s solid aluminum heating units provide consistent temperature for uniform evaporation rates throughout all three plates.</strong></p><p>Each 96-needle manifold is equipped with its own toggle switch to shut down gas flow when all three microplates are not in use to conserve nitrogen gas, saving laboratories money. A convenient dual band spring hoist assembly ensures ease of use for the operator when lowering and raising the needle manifolds. The digital temperature controller is easy to read and allows temperature to be controlled with an accuracy of <strong>+/- 2 °C up to the maximum temperature of 130°C</strong>. &nbsp;An adjustable <strong>0-100 LPM flow meter</strong> is for precise control over the nitrogen gas delivery system.&nbsp;</p><ul><li><strong>High Throughput: </strong>Evaporate up to three 96 well plates at once</li><li><strong>Ease of Use: </strong>Temperature and gas levels are easily set using the digital temperature controller and gas flow meter</li><li><strong>Precise: </strong>Digital controls allow exact temperature regulation</li><li><strong>Cost-Effective: </strong>Conserve nitrogen by turning gas flow on and off at each plate</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_MICROVAP_Triple_Microplate_Evaporator_2_d67a3e5ffd.jpg" alt="Organomation MICROVAP Triple Microplate Evaporator." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_MICROVAP_Triple_Microplate_Evaporator_2_d67a3e5ffd.jpg 156w," sizes="100vw" width="1400" height="1400"></p><h3><strong>STANDARD FEATURES</strong></h3><ul><li>Adjustable flow meter</li><li>Digital temperature control</li><li>High temperature limit switch</li><li>High pressure tubing</li><li>2-inch x 19-gauge needles</li><li>Nitrogen filter</li><li>Anodized aluminum dry block&nbsp;</li></ul><h3><strong>OPTIONS&nbsp;</strong></h3><ul><li>220v wiring harness (Option Code -2), Cat# 11803-2</li><li>Z-Purge/positive pressure purge case (Option Code -Z), Cat# 11803-Z</li><li>Acid resistant coating on instrument and needles (Option Code -RT), Cat# 11803-RT</li></ul><h3><strong>SPECS</strong></h3><h4><strong>12p N-EVAP (Dry Block)</strong></h4><ul><li><strong>Heater Type</strong>: Dry Block</li><li><strong>Instrument Catalog Number</strong>: 11803</li><li><strong>Number of Sample Plates</strong>: 3</li><li><strong>Overall Dimension (w × d × h)</strong>: 21.0 × 13.0 × 13.0 in / 53.3 × 33.02 × 33.02 cm</li><li><strong>Gas Manifold Layout</strong>: Triple 8 × 12 Array</li><li><strong>Center to Center Spacing Between Positions</strong>: 0.354 in / 9.0 mm</li><li><strong>Microplate Dimensions (w × d)</strong>: 3.375 × 5.0 in / 8.5 × 13 cm</li><li><strong>Gas Flow Control</strong>: Single toggle valve</li><li><strong>Gas Flow Meter Range</strong>: 0–100 L/min</li><li><strong>Stainless Steel Needles (Length × Gauge)</strong>: 2.0 in × 19 ga / 51 mm × 19 ga</li><li><strong>Hoist Assembly</strong>: Dual Band Spring Hoist Assembly</li><li><strong>Standard Gas Input Range</strong>: 30 psig</li><li><strong>Gas Input Range with Optional Pressure Reducing Regulator</strong>: 30–160 psig</li></ul><h5><strong>Heating Device Specs</strong></h5><ul><li><strong>Model Number</strong>: 54243</li><li><strong>Outside Dimensions (w × d × h)</strong>: 24.0 × 9.5 × 3.0 in / 61.0 × 22.9 × 7.6 cm</li><li><strong>Total Wattage</strong>: 540 W</li><li><strong>Temperature Range</strong>: 40–130 °C</li><li><strong>Temperature Controller Type</strong>: Digital Electronic with LED Display</li><li><strong>Controller Accuracy</strong>: ±2 °C</li></ul><h3><strong>ACCESSORIES</strong></h3><ul><li>Pressure reducing regulator, 30-150 psi in, 0-30 psi out</li></ul>

Wiley KnowItAll GC-MS Drug Classification Model Package

The KnowItAll GC-MS Drug Classification Model Package categorizes spectra by drug class—even without a match. Covers opioids, steroids, fentanyls, with 99% accuracy for reliable forensics.

<h4><strong>Efficient Drug Classification with KnowItAll GC-MS Models</strong></h4><p>In drug analysis, rapid identification is essential—especially when new substances outpace reference spectra. The <strong>KnowItAll GC-MS Drug Classification Model Package</strong> helps labs <strong>classify unknown spectra</strong>, even without exact spectral matches.</p><p>With <strong>99% accuracy</strong>, these models cover key drug classes like <strong>opioids, steroids, fentanyls</strong>, and more. Ideal for <strong>forensics, toxicology, and law enforcement</strong>, the package enhances your ability to:</p><ul><li>Classify spectra not found in libraries</li><li>Validate spectral search results</li><li>Make fast, first-pass identifications</li><li>Run batch or automated classifications using the <strong>KnowItAll Automate SDK</strong></li></ul><h5><strong>Included Drug Models:</strong></h5><ul><li>Natural &amp; synthetic opioids</li><li>Fentanyls</li><li>Piperazines</li><li>Benzodiazepines</li><li>Steroids</li><li>Ketamine, cocaine, cathinones &amp; related compounds</li></ul><p><strong>Requirements:</strong> KnowItAll software + AVX-compatible system.<br><strong>Learn more: </strong><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com">sciencesolutions.wiley.com</a></p>

Wiley KnowItAll Solutions for GC-MS

KnowItAll combines advanced tools with Wiley’s trusted spectral databases to identify, analyze, and manage your GC-MS data quickly and reliably in any lab environment.

<h4><strong>KnowItAll GC-MS Solutions – Powerful, Integrated Spectral Analysis</strong></h4><p><strong>KnowItAll GC-MS</strong> from Wiley combines advanced software tools and high-quality spectral data in one intuitive platform—boosting lab efficiency and enabling fast, confident compound identification.</p><h5><strong>Key Features:</strong></h5><ul><li><strong>Automated non-targeted analysis:</strong> MS Expert automatically deconvolutes and analyzes GC-MS data, streamlining workflows.</li><li><strong>Spectral search &amp; processing:</strong> Fast, accurate search tools with features like adaptive search and mixture analysis for complex spectra.</li><li><strong>Comprehensive GC-MS database:</strong> Access over <strong>956,000 spectra</strong> or expand to <strong>1.3 million</strong> with optional NIST integration.</li><li><strong>Data management:</strong> Build and search multi-technique databases (IR, MS, NMR, UV-Vis, Raman) with flexible vendor support.</li><li><strong>Structure drawing &amp; reporting:</strong> Integrated ChemWindow tools for seamless structure handling and report creation.</li><li><strong>Quantitation tool:</strong> Analyze "how much" with built-in quantification, included in the Analytical Edition.</li></ul><h5><strong>Applications:</strong></h5><p>Ideal for workflows in <strong>pharma, forensics, metabolomics, environmental testing, food safety, academia,</strong> and more.</p><h5><strong>Compatibility:</strong></h5><p>Supports most MS instrument formats and remains workflow-stable across hardware changes thanks to its vendor-neutral design.</p>

Comprehensive Hydrocarbon Group-Type Analysis by ASTM D8396 (GC×GC-FID)

At LabRulez, we deliver high-resolution quantification of hydrocarbon group types in complex fuel matrices using GC×GC-FID with thermal modulation, fully compliant with ASTM D8396. 

<p><strong>At LabRulez, we deliver high-resolution quantification of hydrocarbon group types in complex fuel matrices using GC×GC-FID with thermal modulation, fully compliant with ASTM D8396. This method is ideal for samples with boiling points between 36 °C and 451 °C, such as jet fuels, diesel, and synthetic blends.</strong></p><p>✔️ Detailed profiling of <i><strong>n</strong></i><strong>-paraffins, iso-paraffins</strong>, <strong>naphthenes</strong>, and <strong>aromatics (one-ring, two+ rings)</strong><br>✔️ <strong>Custom analysis options available</strong>—targeted compounds or stream-specific reporting upon request.</p><p>This method provides precise and high-resolution profiling of hydrocarbon group types across a broad boiling range (36 °C to 451 °C). Using orthogonal GC×GC separation with polar and non-polar column chemistries, it offers unparalleled resolution of complex fuel matrices. Its performance has been validated through interlaboratory studies, making it ideally suited for quality assurance, process optimization, and regulatory compliance.</p><p><strong>ASTM D8396 </strong>quantifies key hydrocarbon classes—<i>n</i>-paraffins (up to C30), iso-paraffins, naphthenes, one-ring aromatics, and two-ring plus aromatics—with excellent repeatability across diverse fuel types. Results are generated using template-based quantification, ensuring consistency and reproducibility between samples and over time.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Precision_Range_wt_final_5079960ca7.jpg" alt="Table 1: Precision Range (wt. %)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Precision_Range_wt_final_5079960ca7.jpg 245w," sizes="100vw" width="1600" height="631"></p><p>This method may also be applied to other hydrocarbon types—such as <strong>benzene, toluene, and individual </strong><i><strong>n</strong></i><strong>-paraffins by carbon number</strong>—as well as alternative hydrocarbon streams. However, validated precision data is currently limited to the groups above.</p><p><strong>Targeted component analysis</strong> (e.g., BTEX, PAHs, or carbon-specific paraffins) and <strong>customized reporting</strong> are available upon request.</p><h5><strong>Samples suitable for this technique include:</strong></h5><ul><li>Jet fuel (Jet A, A-1, synthetic aviation fuels)</li><li>Paraffinic diesel and HVO (Hydrotreated Vegetable Oil)</li><li>Synthetic fuels (GTL, BTL, FT-diesel)</li><li>Gasoline and reformulated gasoline streams</li><li>Complex refinery intermediates with low olefin content</li></ul><h5><strong>Sample Requirements and Logistics:</strong></h5><ul><li><strong>Sample Volume:</strong> 5 mL&nbsp;</li><li><strong>Typical Turnaround:</strong> 3–5 business days</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Comprehensive_Hydrocarbon_Group_Type_Analysis_by_ASTM_D8396_GC_GC_FID_aea925cd0a.jpg" alt="Comprehensive Hydrocarbon Group-Type Analysis by ASTM D8396 (GC×GC-FID)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Comprehensive_Hydrocarbon_Group_Type_Analysis_by_ASTM_D8396_GC_GC_FID_aea925cd0a.jpg 245w," sizes="100vw" width="600" height="267"></p>

EST Analytical CENTURION Water/Soil Purge and Trap Autosampler

The EST Analytical CENTURION delivers reliable purge and trap VOC analysis with high sample capacity, robust design, and intuitive software for water and soil testing.

<p><strong>The CENTURION is a flexible purge and trap autosampler available in two configurations: a combined water/soil system or a water-only system. Purge and trap technology enables the extraction of volatile organic compounds (VOCs) from samples by purging them with an inert gas onto a sorbent trap, where they are concentrated and subsequently transferred into instruments such as GC or GC/MS for precise analysis.</strong></p><p>Designed for laboratories worldwide, the CENTURION enhances throughput, ensures reliable performance, and simplifies VOC sample preparation. With robust engineering and intuitive software, it helps analysts and technicians maximize efficiency and maintain consistent results across demanding workflows.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/EST_Analytical_CENTURION_Water_Soil_Purge_and_Trap_Autosampler_3_3cb7b848e1.jpg" alt="EST Analytical: CENTURION Water/Soil Purge and Trap Autosampler" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_EST_Analytical_CENTURION_Water_Soil_Purge_and_Trap_Autosampler_3_3cb7b848e1.jpg 141w," sizes="100vw" width="704" height="778"></p><h4><strong>Key Features</strong></h4><h5><strong>Reliable Purge &amp; Trap Performance</strong></h5><ul><li>Proven XYZ autosampler design with heavy-duty rails for stability</li><li>Separate needles for water and soil samples to prevent cross-contamination</li><li>Internal standard addition with <strong>&lt;3% RSD precision</strong></li><li>Engineered for consistent results right from the start</li></ul><h5><strong>Optimized Productivity</strong></h5><ul><li>Supports <strong>up to 100 water samples</strong> and <strong>90 soil samples</strong></li><li>Single calibration method accommodates both water and soil matrices</li><li>Integrated optical sensors reduce vial and syringe handling errors</li><li>Includes methanol extraction capability and optional pH detection</li></ul><h5><strong>User-Friendly Operation</strong></h5><ul><li>Unique software for prioritizing urgent/rush samples</li><li><strong>400:1 dilution capability</strong> for flexible workflows</li><li>Intuitive control software accessible from any PC in the lab</li><li>Programmable soil needle depth to minimize clogging</li><li>Automated hot water rinse cycle to reduce carryover</li></ul><h4><strong>Technical Specifications</strong></h4><ul><li><strong>Configurations</strong>: Water/Soil purge &amp; trap system or Water-only system</li><li><strong>Sample Capacity</strong>: 100 water samples / 90 soil samples</li><li><strong>Dilution Capability</strong>: Up to 400:1</li><li><strong>Carryover Control</strong>: Programmable hot water rinse</li><li><strong>Additional Functions</strong>: Methanol extraction, pH detection (optional)</li><li><strong>Software</strong>: Intuitive, PC-based control with rush sample handling</li></ul>

EST Analytical EVOLUTION 2 Purge and Trap Concentrator

The EST Analytical EVOLUTION 2 concentrator delivers EPA-compliant VOC analysis with patented flow control, faster cycles, and compact, user-friendly design.

<p><strong>Developed with direct input from laboratory users, the EVOLUTION 2 purge and trap concentrator combines USEPA compliance with high productivity, stability, and simplified maintenance. Designed for reliable VOC concentration, it delivers superior performance and minimizes downtime, making it an ideal solution for today’s demanding laboratory environments.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/EST_Analytical_EVOLUTION_2_Purge_and_Trap_Concentrator_2_b841c750b8.jpg" alt="EST Analytical: EVOLUTION 2 Purge and Trap Concentrator" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_EST_Analytical_EVOLUTION_2_Purge_and_Trap_Concentrator_2_b841c750b8.jpg 129w," sizes="100vw" width="570" height="689"></p><h4><strong>Key Features</strong></h4><h5><strong>Engineered for Accuracy</strong></h5><ul><li>Unique 8-port valve pathway ensures advanced moisture control</li><li>Enhanced ventilation system shortens trap cool-down times</li><li>Patented <strong>Desorb Pressure Control (DPC)</strong> for improved chromatography results</li><li>Patented <strong>Desorb Flow Control (DFC)</strong> optimized for USEPA 524 methods</li></ul><h5><strong>Maximized Productivity</strong></h5><ul><li>Faster trap cooling reduces cycle times</li><li>Automated signaling boosts sample throughput</li><li>Innovative flow path design minimizes sample carryover</li><li>Proven <strong>Moisture Reduction Trap (MORT)</strong> technology</li><li>Dual-mode functionality for higher output and flexibility</li></ul><h5><strong>User-Friendly Operation</strong></h5><ul><li>Intuitive, advanced software interface</li><li>Quick-access design with removable covers for trap maintenance</li><li>Compact footprint saves valuable bench space</li></ul><h4><strong>Technical Specifications</strong></h4><ul><li><strong>Compliance</strong>: USEPA 524 and related VOC methods</li><li><strong>Sample Pathway</strong>: 8-port valve with advanced moisture control</li><li><strong>Patented Features</strong>: DPC (Desorb Pressure Control), DFC (Desorb Flow Control), MORT (Moisture Reduction Trap)</li><li><strong>Productivity</strong>: Dual-mode operation, automated cycle optimization</li><li><strong>Design</strong>: Compact footprint, easy maintenance access</li></ul>

EST Analytical AS120 Autosampler

The AS120 GC Autosampler boosts productivity with dual-injector support, 120/200 vial capacity, programmable injections, and seamless GC/GC-MS integration.

<p><strong>The AS120 Autosampler is a cost-effective, fully electric XYZ sampler for GC and GC/MS applications. Driven by stepper motor technology, it combines modern engineering with user-friendly operation, meeting both routine and advanced analytical needs. With high-capacity sample trays, flexible injection modes, and reliable performance, the AS120 ensures laboratories can boost productivity while maintaining precise, consistent results.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/EST_Analytical_AS_120_Autosampler_7cc5a79884.jpg" alt="EST Analytical: AS120 Autosampler" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_EST_Analytical_AS_120_Autosampler_7cc5a79884.jpg 203w," sizes="100vw" width="1056" height="812"></p><h4><strong>Key Features</strong></h4><h5><strong>Maximum Productivity</strong></h5><ul><li>Dual-injector capability for maximum GC throughput</li><li>Automated injector alignment—no manual adjustments required</li><li>Variable injection rate tailored to injector type and analytical method</li><li>Choice of 120- or 200-position sample trays, easily removable for quick loading</li></ul><h5><strong>Durable, Flexible Engineering</strong></h5><ul><li>Robust XYZ syringe mechanism accesses vials, solvents, and standards with precision</li><li>Adjustable parameters: injection volume, speed, dwell times, and solvent flush options</li><li>Supports multiple methods per sequence and dual-column operation</li><li>Fully programmable via intuitive keypad interface</li></ul><h5><strong>Hassle-Free Operation</strong></h5><ul><li>Compatible with screw-cap and crimp-top septum vials</li><li>Simple GC integration with standard remote I/O signals and RS-232 communication</li><li>Quick mounting with keypad-based syringe/injector alignment</li><li>Priority manual sample feature enables urgent “RUSH” sample handling</li></ul><h4><strong>Technical Specifications</strong></h4><ul><li><strong>Drive</strong>: All-electric, stepper motor XYZ system</li><li><strong>Capacity</strong>: 120 or 200 vial tray options</li><li><strong>Compatibility</strong>: GC and GC/MS systems with standard I/O and RS-232 interface</li><li><strong>Injection Modes</strong>: Variable rate, programmable volume, dual-injector support</li><li><strong>Control</strong>: Keypad-driven menu with multiple method programming</li><li><strong>Sample Handling</strong>: Screw-cap or crimp-top septum vials</li></ul>

EST Analytical FLEX 2 Robotic Sampling Platform

The FLEX 2 autosampler streamlines GC/GC-MS workflows with liquid, headspace, and SPME capability, MTX tool change, and Prep Ahead for faster, more reliable VOC analysis.

<p><strong>The FLEX 2 is a versatile GC autosampler designed to handle both sample preparation and sample introduction for GC and GC/MS analysis. Supporting liquid injection, headspace, and SPME, it delivers exceptional accuracy and reproducibility. Its Prep Ahead function improves efficiency by allowing sample preparation during ongoing GC runs, maximizing system utilization and throughput.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/EST_Analytical_FLEX_2_Robotic_Sampling_Platform_3_853e02f151.jpg" alt="EST Analytical: FLEX 2 Robotic Sampling Platform" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_EST_Analytical_FLEX_2_Robotic_Sampling_Platform_3_853e02f151.jpg 168w," sizes="100vw" width="628" height="584"></p><h4><strong>Key Features</strong></h4><h5><strong>Flexible Sample Preparation with Multi Tool Change (MTX)</strong></h5><ul><li>Automated <strong>Multi Tool Change (MTX)</strong> enables seamless switching between tools</li><li>Enhances laboratory productivity, accuracy, and safety by reducing manual prep errors</li><li>Supports dilution, reagent addition, and internal standard spiking with precision</li><li>Can operate as a benchtop preparation station for derivatization and extraction steps</li></ul><h5><strong>Liquid Injection Capabilities</strong></h5><ul><li>Injection range: <strong>0.5–10 μL</strong> (standard syringe) or <strong>50–500 μL</strong> (optional large-volume syringe)</li><li>Supports both standard and large-volume injections (up to 500 μL)</li><li>Programmable injection speed control, from ultra-fast to very slow</li><li>Optional cooled trays available for temperature-sensitive samples</li></ul><h5><strong>Headspace Sampling</strong></h5><ul><li>Injection range: <strong>100–2500 μL</strong> (2.5 mL syringe), <strong>100–1000 μL</strong> (1.0 mL syringe), or <strong>500–5000 μL</strong> (5.0 mL syringe)</li><li>Offers both <strong>orbital</strong> and <strong>oscillating</strong> agitation to improve sample consistency</li><li>Six heated vial positions for <strong>2, 10, or 20 mL vials</strong></li><li>Temperature range: <strong>ambient to 200 °C</strong></li><li>Shaking: orbital (120–750 rpm) or oscillation (190 Hz)</li></ul><h5><strong>Automated SPME</strong></h5><ul><li>Compatible with both traditional and direct immersion SPME methods</li><li>Heated conditioning station:<ul><li>Fiber: <strong>ambient to 350 °C</strong></li><li>Needle: <strong>ambient to 150 °C</strong></li><li>Sweep gas port for conditioning</li></ul></li><li>Heated mixing station: <strong>ambient to 150 °C</strong>, mixing speeds <strong>380–725 rpm</strong></li></ul><h5><strong>Efficiency &amp; Throughput</strong></h5><ul><li><strong>Prep Ahead function</strong> allows ongoing sample prep during GC runs</li><li>Fully automates switching between liquid injection, headspace, and SPME with MTX</li><li>Reduces manual workload and preparation errors while improving reproducibility</li></ul><h4><strong>Technical Specifications</strong></h4><ul><li><strong>Compatible Systems</strong>: GC and GC/MS platforms</li><li><strong>Injection Modes</strong>: Liquid (0.5–500 μL), Headspace (100–5000 μL), SPME (traditional &amp; direct immersion)</li><li><strong>Temperature Ranges</strong>: Headspace up to 200 °C, SPME fiber up to 350 °C, SPME needle up to 150 °C</li><li><strong>Agitation</strong>: Orbital (120–750 rpm) and oscillating (190 Hz)</li><li><strong>Capacity</strong>: Six heated vial positions for 2, 10, or 20 mL vials</li><li><strong>Automation</strong>: Multi Tool Change (MTX), Prep Ahead function</li></ul>

EST Analytical LGX-50 for Methane in Water

The EST LGX-50 automates RSK-175 dissolved gas testing in water, boosting throughput, ensuring ASTM/EPA compliance, and reducing manual sample preparation errors.

<p><strong>The LGX-50 automates the preparation of water samples for headspace analysis of dissolved gases such as methane, ethane, and ethene. Traditionally, RSK-175 testing has been labor-intensive and time-consuming, requiring manual vial preparation. The LGX-50 eliminates this step, streamlining workflows and ensuring compliance with EPA Method 5035 and ASTM D8028. By automating dissolved gas extraction, laboratories can boost throughput, reduce errors, and deliver more consistent results for shale gas and environmental testing.</strong></p><h4><strong>Key Features</strong></h4><h5><strong>Maximized Productivity</strong></h5><ul><li>Fully automates <strong>RSK-175 sample processing</strong></li><li>ASTM D8028 compliant for dissolved gas testing</li><li>Holds up to <strong>50 samples</strong> for high-throughput operation</li><li>Optical sensors prevent vial misplacement and syringe/elevator errors</li><li>Robust XYZ design ensures reliability and consistent performance</li></ul><h5><strong>Simplified Operation</strong></h5><ul><li>Intuitive, user-friendly software designed for quick setup and operation</li><li>Remote access functionality allows labs to monitor sample progress via the server</li><li>Reduces manual preparation steps, increasing accuracy and reproducibility</li></ul><h4><strong>Technical Specifications</strong></h4><ul><li><strong>Compliance</strong>: EPA Method 5035, ASTM D8028</li><li><strong>Capacity</strong>: Up to 50 samples per batch</li><li><strong>Target Compounds</strong>: Methane, ethane, ethene, and other dissolved gases in water</li><li><strong>Automation</strong>: XYZ robotic design with optical sensors for error prevention</li><li><strong>Software</strong>: Intuitive, remote-access capable interface</li></ul>

BaySpec Continuity Portable Mass Spectrometer

Continuity™ is a highly sensitive portable mass spectrometer with built-in MS/MS, broad mass range, and ambient ionization, delivering real-time, lab-quality analysis directly in the field without sample preparation.

<h3><strong>Higher sensitivity portable mass spectrometer</strong></h3><p><strong>Continuity™ - the most sensitive portable mass spectrometer designed to provide quality and reliable mass spectrometer analysis outside of the laboratory. Continuity™ was created to provide even higher sensitivity, greater specificity with built-in MS/MS, and larger mass range coverage than its ground-breaking counterpart Portability™.&nbsp;</strong></p><p>Like its counterpart, Continuity™ requires no sample preparation and is compatible with almost any ambient ionization source including ESI, APCI, TD-ESI, TD-APCI, and DBDI. It allows for a broad range of applications from clinical to drug to chemical and biological threats analysis. The user-friendly interface, rapid deployment, and real-time results make Continuity™ a great solution for fast, dependable, and highly sensitive field analysis for any user in any location. This potable mass spectrometer is the excellent solution for various challenging applications, including vapors/liquids/solids, CWAs/TICs, biological/biomedical, forensic, agriculture, food safety, security, and explosives.</p><h4><strong>Key Features</strong></h4><ul><li>Portable and High Sensitivity</li><li>Vapors, Liquids, Solids</li><li>Ambient Ionization</li><li>MS/MS Analysis</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Field Analysis Ready</li><li>Real-time Results</li></ul><h4><strong>Technical specification</strong></h4><ul><li><strong>Mass Range: </strong>m/z = 50 – 1200 amu&nbsp;&nbsp;</li><li><strong>Detection Limit: </strong>High parts-per-trillion/ picograms</li><li><strong>Mass Resolution: </strong>0.49 amu (FWHM)&nbsp;&nbsp;&nbsp;&nbsp;</li><li><strong>MS/MS Capability:</strong> Yes&nbsp;&nbsp;</li><li><strong>Dimension:</strong> 15 x 15 x 15.5 in&nbsp;&nbsp;&nbsp;</li><li><strong>Weight:</strong> 44 lbs. (20 kg)</li></ul>

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