<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 25th May 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application note by<strong> Shimadzu, </strong>presentation by <strong>MDCW / University of Washington</strong> and poster by <strong>Waters Corporation!</strong></p><h3><strong>1. MDCW / University of Washington: Implementing Tile-Based Fisher Ratio Analysis of GC×GC-TOFMS Data to Obtain a Master Peak Table of All Detected Analyte Compounds in Many Petroleum-Based Samples</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_9_Halvorsen_136808e314.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>This presentation describes the development of a new chemometric workflow for processing <strong>GC×GC-TOFMS (comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry)</strong> data from petroleum-derived fuels. The work was conducted by researchers from the University of Washington in collaboration with Chevron Technical Center and focuses on creating a comprehensive <strong>Master Peak Table (MPT)</strong> containing all detectable analytes across multiple fuel sample classes. The motivation was that moving from conventional GC to GC×GC dramatically increased chromatographic peak capacity and resolution, but also created a need for more sophisticated data analysis methods capable of handling the much larger number of detected compounds.</p><p>The analytical platform employed <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37"><strong>GC×GC-TOFMS</strong></a> with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1289"><strong>thermal-flow modulator</strong></a> and a TOF mass spectrometer detector. Fuel samples were analyzed using an <strong>Rxi-1 column (30 m × 0.25 mm × 0.25 μm)</strong> in the first dimension and an <strong>Rxi-17MS column (2.0 m × 0.18 mm × 0.20 μm)</strong> in the second dimension. The sample set included multiple petroleum products such as hydrobates, reformates, naphthas, FCC gasoline, and blank samples. Log-scale chromatograms revealed numerous late-eluting trace compounds and significant compositional differences between fuel batches that were not readily visible in conventional chromatographic representations.</p><p>To process these highly complex datasets, the researchers implemented a <strong>tile-based Fisher Ratio (F-ratio) chemometric approach</strong> using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348"><strong>ChromaTOF Tile software</strong></a>. The method divides GC×GC chromatograms into small tiles and identifies regions where analyte signals differ significantly between sample classes by comparing between-class and within-class variance. Instead of relying solely on F-ratio ranking, the workflow incorporates statistical testing against blank samples. Three blank chromatograms were used to establish tile-specific confidence intervals and p-test thresholds, allowing the system to determine whether detected signals represent genuine compounds rather than background noise. This strategy enabled the creation of a unified master peak table while minimizing problems caused by retention-time shifts and reducing the need for manual user intervention.</p><p>Application of the method generated <strong>719 statistically significant analyte hits</strong> across the fuel classes and demonstrated excellent reproducibility, with only <strong>6.3% of classifications showing inconsistent behavior among replicates</strong>. Detected compounds included hydrocarbons and aromatic species such as <strong>1-methylnaphthalene, 1,2,4-trimethylbenzene, β-vatirenene, 2-octene, and tetramethylheptadecane</strong>, whose occurrence patterns aligned well with expected fuel chemistry. The resulting master peak table contained both shared and sample-specific compounds and provided a much more comprehensive representation of petroleum composition than conventional workflows. The authors conclude that the approach should be broadly applicable to other complex sample types and could be extended using alternative chemometric metrics beyond Fisher Ratio analysis to address different experimental objectives.</p><h3><strong>2. Shimadzu: A Simple Method for Determination of β-Sitosterol as a Marker of Vegetable Oil Adulteration in Ghee by GC</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_06_sip_gc_042_en_f4c307005b.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>ShimadzuNexis GC-2030 can be effectivelyused for determination of adulteration of Ghee with vegetable oil.</li><li>The NexisGC-2030 easily meets the acceptancecriteria as per the proposed FSSAI method no.01.097:2022.</li><li>This method is suitable for routine food industry analysis and academic research.</li></ul><p>The most common milk product in Indian cuisine is ghee or clarified butter. Due to its high cost, ghee is adulterated with vegetable oil, to gain commercial benefits. β-sitosterol, a common phytosterol, found in a variety of natural sources, including vegetable fat or oil from plants (Figure 1). It is used as a marker of vegetable oil adulteration in ghee<sup>1</sup>.</p><p>The primary goal of this study is to assess the vegetable oil adulteration in ghee by analyzing β-Sitosterol as a marker using gas chromatography (GC). This will establish a foundation for the rapid detection of ghee adulteration. In this study, a simple, sensitive, and inexpensive method is developed for extraction of β-Sitosterol from ghee which is then subjected to gas chromatography with flame ionization detection for quantitation. The effects of several important parameters influencing the extraction efficiencies of β-Sitosterol including water-immiscible organic solvent (type and volume), volume of water, sonication time, surfactant (type and concentration), and organic modifier (type and volume) were investigated. This method is ideal for routine analysis in the food industry during the manufacturing, processing, and commercial testing of milk fat samples, or for academic research purposes.</p><h4><strong>&nbsp;Sample Preparation and Analysis Conditions</strong></h4><p>Standard and sample preparations were conducted following the guidelines outlined in the proposed FSSAI method No. 01.097:20222. The analysis was performed using a Shimadzu <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2030"><strong>Nexis GC-2030</strong></a> equipped with a Flame Ionization Detector (FID), as shown in Figure 2. The specific configuration and analytical conditions used during the study are provided in Table 1.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>A gas chromatography–based method using GC-2030 was developed for the estimation of β-Sitosterol in ghee. The method exhibits a detection limit of 2 %, enabling the identification of vegetable oil adulteration in ghee at levels as low as 2 %. At this adulteration level, the signal of β-Sitosterol achieved a signal-to-noise (S/N) greater than 3, confirming the reliability of detection at the established limit. This method provides a reliable and effective approach for the quantification of β-Sitosterol, which serves as a marker for vegetable oil adulteration in ghee.</p><h3><strong>3. Waters Corporation: Multidimensional Characterization of Short Chain Chlorinated Paraffins (SCCPs) with GC-APCI and Cyclic Ion Mobility</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009386_3232568115.pdf"><strong>Full PDF for download</strong></a></li></ul><p>This poster presents a multidimensional analytical approach for the characterization of <strong>short-chain chlorinated paraffins (SCCPs)</strong>, a class of persistent environmental pollutants included in the Stockholm Convention due to their environmental persistence and bioaccumulation potential. SCCPs are highly complex mixtures of chlorinated hydrocarbons containing thousands of possible congeners, making their analysis particularly challenging. The study evaluates the use of <strong>gas chromatography coupled with atmospheric pressure chemical ionization, cyclic ion mobility spectrometry, and high-resolution mass spectrometry (GC-APCI-IMS-HRMS)</strong> as a powerful platform for improved SCCP characterization.</p><p>The analytical instrumentation consisted of a modified <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890"><strong>Agilent 8890 gas chromatograph</strong></a> equipped with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=7&amp;search=Rxi-5SilMS"><strong>Rxi-5SilMS capillary column</strong></a><strong> (30 m × 0.25 mm × 0.25 μm)</strong> and connected to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/202"><strong>Waters SELECT SERIES Cyclic IMS</strong></a><strong> high-resolution mass spectrometer</strong> using an <strong>Atmospheric Pressure GC (APGC) ion source</strong>. Unlike conventional electron ionization methods, APCI was operated in negative-ion mode with a chloroform modifier, promoting the formation of characteristic <strong>[M+Cl]⁻ molecular ions</strong>. This significantly reduced fragmentation and provided strong molecular-ion signals, improving both qualitative identification and quantitative analysis of SCCP homologues.</p><p>Using three commercial SCCP technical mixtures (51.5%, 55%, and 63% chlorine content), the researchers demonstrated that GC-APCI-HRMS could selectively detect SCCP homologues according to carbon-chain length and degree of chlorination. Although substantial chromatographic overlap was observed among many homologues, the addition of <strong>ion mobility spectrometry (IMS)</strong> introduced a valuable extra separation dimension. Distinct drift-time versus m/z trendlines were observed for compounds sharing the same number of chlorine atoms, allowing homologues to be grouped and characterized more effectively than by chromatographic retention and mass spectrometry alone. The IMS data also enabled estimation of the relative abundance of individual homologue groups within each technical mixture.</p><p>The authors further explored the resolving power of the <strong>cyclic IMS device</strong> by employing multiple ion-mobility passes (up to eight cycles) to investigate individual SCCP congeners. While complete separation of individual congeners within a homologue group was not achieved, higher ion-mobility resolution revealed measurable differences between early- and late-eluting species and provided additional insight into compositional differences among SCCP mixtures. The study concludes that combining <strong>GC-APCI, cyclic ion mobility spectrometry, and high-resolution mass spectrometry</strong> offers a powerful multidimensional workflow for the characterization of complex chlorinated paraffin mixtures and may improve environmental monitoring and future regulatory analysis of these challenging contaminants.</p></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 22, 2026

<p><strong>Low analyte recovery is one of the most common challenges encountered during Solid Phase Extraction (SPE) sample preparation. In this Phenomenex Video Tip, Genevie Hodson, Senior Manager of Technical Support and Applications at Phenomenex, explains a practical troubleshooting approach for situations where analyte recovery after an </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=6&amp;manufacturerItems=50"><strong>SPE </strong></a><strong>procedure is lower than expected.</strong></p><p>The key objective of troubleshooting is not simply to identify that recovery is low, but to determine exactly where the analyte was lost during the extraction process. Once the point of loss has been identified, corrective actions can be implemented systematically.</p><h3><strong>Fundamental Principle of SPE Recovery Troubleshooting</strong></h3><h4><strong>Determine Where the Analyte Is Going</strong></h4><p>The most important step when troubleshooting low recovery is to identify the location of the missing analyte.</p><p>The process begins with the assumption that the sample originally contained 100% of the target analyte. If the final recovery is lower than expected, some portion of the analyte has been lost during SPE processing.</p><p>To identify the loss point, each fraction generated during the SPE procedure must be collected and analyzed separately.</p><h5><strong>Fractions to Collect</strong></h5><p>During the SPE workflow, the following fractions should be collected individually:</p><ul><li><strong>Load fraction (flow-through)</strong></li><li><strong>Wash fraction(s)</strong></li><li><strong>Elution fraction</strong></li></ul><p>Each collected fraction is transferred into a vial and analyzed using the laboratory’s analytical method.</p><p><strong>The analytical results reveal whether the analyte is:</strong></p><ul><li>Present in the load fraction</li><li>Present in one of the wash fractions</li><li>Present in the elution fraction</li><li>Missing from all collected fractions</li></ul><p>The location of the analyte provides direct information about the root cause of the recovery problem and guides the next troubleshooting steps.</p><h4><strong>Scenario 1: Analyte Detected in the Load Fraction</strong></h4><h5><strong>What It Means</strong></h5><ul><li>If the analyte appears in the load fraction, it was not retained by the SPE sorbent during sample loading.</li><li>Instead of binding to the stationary phase, the analyte passed directly through the cartridge.</li></ul><h5><strong>Possible Causes</strong></h5><ol><li><strong>Incorrect Phase Selection</strong></li></ol><ul><li>The selected SPE sorbent may not be appropriate for the analyte being extracted.</li><li>If the analyte cannot interact effectively with the sorbent chemistry, retention will not occur.</li></ul><ol start="2"><li><strong>Excessively Strong Sample Solvent</strong></li></ol><ul><li>The sample may be dissolved in a solvent that is too strong.</li><li>A strong sample solvent can prevent proper interaction between the analyte and the sorbent, causing breakthrough during loading.</li></ul><ol start="3"><li><strong>Incorrect pH Conditions</strong></li></ol><ul><li>Retention often depends on maintaining the analyte in the correct ionization state.</li><li>If the sample pH is not appropriate, the analyte may not interact correctly with the sorbent and therefore will not be retained.</li></ul><ol start="4"><li><strong>Sorbent Overload</strong></li></ol><ul><li>The SPE cartridge may have received:<ul><li>Too much analyte</li><li>Too much sample matrix</li></ul></li><li>When sorbent capacity is exceeded, analytes can break through the cartridge and appear in the load fraction.</li></ul><h5><strong>Corrective Action</strong></h5><p>When overload is suspected, increasing the amount of sorbent can improve analyte retention and prevent breakthrough.</p><h4><strong>Scenario 2: Analyte Detected in the Wash Fraction</strong></h4><h5><strong>What It Means</strong></h5><p>If the analyte appears in the wash fraction, it was initially retained but subsequently removed during the washing step.</p><h5><strong>Possible Causes</strong></h5><ol><li><strong>Wash Solvent Too Strong</strong></li></ol><ul><li>The most common cause is an overly aggressive wash solvent.</li><li>A wash solution with excessive elution strength can remove the analyte before the intended elution step.</li></ul><ol start="2"><li><strong>Incorrect pH During Washing</strong></li></ol><ul><li>When pH control is required for retention, the same conditions must be maintained throughout the process.</li><li>A pH change during washing may alter analyte retention and cause premature elution.</li></ul><h5><strong>Corrective Action</strong></h5><p><strong>Review:</strong></p><ul><li>Wash solvent composition</li><li>Wash solvent strength</li><li>pH conditions during washing</li></ul><p>Adjustments should ensure that the analyte remains retained until the elution step.</p><h4><strong>Scenario 3: Analyte Missing from All Fractions</strong></h4><h5><strong>What It Means</strong></h5><ul><li>If the analyte is not found in the load fraction, wash fractions, or elution fraction, it is likely still retained on the SPE sorbent.</li><li>In this situation, the analyte has not been effectively eluted from the cartridge.</li></ul><h5><strong>Possible Cause</strong></h5><p><strong>Elution Solvent Not Strong Enough</strong></p><ul><li>The final elution solvent may lack sufficient strength to remove the analyte from the sorbent.</li><li>As a result, the analyte remains bound to the stationary phase and never reaches the collection vial.</li></ul><h4><strong>Corrective Action</strong></h4><ul><li>Increase the strength of the elution solvent during the final SPE elution step.</li><li>A stronger solvent can improve analyte desorption and recovery.</li></ul><h3><strong>Summary of Low Recovery Troubleshooting Strategy</strong></h3><p>The recommended troubleshooting workflow consists of four steps:</p><h4><strong>1. Collect All SPE Fractions</strong></h4><p><strong>Gather:</strong></p><ul><li>Load fraction</li><li>Wash fraction(s)</li><li>Elution fraction</li></ul><h4><strong>2. Analyze Each Fraction Separately</strong></h4><p>Use the analytical method to determine where the analyte is located.</p><h4><strong>3. Identify the Root Cause</strong></h4><div><div><h5><strong>Analyte Location&nbsp;&nbsp;/&nbsp;&nbsp;Likely Cause</strong></h5><ul><li><strong>Load fraction:</strong> Incorrect phase, strong sample solvent, incorrect pH, sorbent overload</li><li><strong>Wash fraction: </strong>Wash solvent too strong, incorrect pH</li><li><strong>Not found in any fraction:</strong> Incomplete elution from sorbent</li></ul></div></div><h4><strong>4. Apply Corrective Measures</strong></h4><p><strong>Modify:</strong></p><ul><li>Sorbent selection</li><li>Sample solvent composition</li><li>pH conditions</li><li>Sorbent amount</li><li>Wash solvent strength</li><li>Elution solvent strength</li></ul><h3><strong>Other Common SPE Issues</strong></h3><p>In addition to low recovery, several other SPE-related problems are commonly encountered.</p><p><strong>These include:</strong></p><ul><li>Contamination</li><li>Reproducibility Problems</li><li>Flow-Related Issues</li></ul><h3><strong>Conclusion</strong></h3><p>Successful troubleshooting of low SPE recovery depends on identifying where the analyte is lost during the extraction process. Collecting and analyzing individual SPE fractions provides a systematic method for locating the analyte and determining the underlying cause of poor recovery.</p><p>Whether the analyte passes through during loading, elutes during washing, or remains bound to the sorbent after extraction, fraction-based investigation enables targeted corrective actions. This structured approach allows SPE methods to be optimized efficiently and helps restore acceptable analyte recovery.</p>

SPE Troubleshooting: Understanding and Resolving Low Recovery in Solid Phase Extraction

<p><strong>New edition of the Wiley Registry of Mass Spectral Data expands compound coverage to over 915,500 reference spectra, strengthening a foundational layer of Wiley’s scientific data and research intelligence portfolio.</strong></p><p>Wiley, a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation and learning, today released the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/887"><strong>Wiley Registry of Mass Spectral Data 2026</strong></a>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Registry_of_Mass_Spectral_Data_2026_bc408d8245.jpg" alt="Wiley: Registry of Mass Spectral Data 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Registry_of_Mass_Spectral_Data_2026_bc408d8245.jpg 110w," sizes="100vw" width="1527" height="2162"></p><p>As AI-driven research pipelines become standard practice across pharmaceuticals, materials science and forensic investigation, the quality of reference data underpinning those pipelines determines whether results are trusted—or stall at the verification stage.</p><p>The Wiley Registry of Mass Spectral Data 2026 addresses this issue directly: <strong>One of the world’s largest and most trusted mass spectral reference databases</strong> for identifying unknown chemical compounds, it is now expanded and validated to meet the analytical demands of modern, AI-assisted laboratory workflows.</p><p>Laboratories face increasingly complex analytical challenges—from detecting emerging environmental contaminants to identifying novel substances in forensic investigations. As a result, having access to a comprehensive, rigorously validated spectral database has become foundational to getting results right. It is also a critical validation layer for AI-driven workflows.</p><p>The Wiley Registry database helps scientists and researchers around the world with <strong>environmental testing, forensic investigation, food safety research, drug analysis, defense research, homeland security</strong>, and more, providing critical reference data for identifying and analyzing chemical compounds and materials.</p><p>The new edition represents a significant expansion of the collection, which now contains <strong>more than 915,500 reference spectra</strong>—the unique chemical “signatures” used to identify substances—making it among the most comprehensive databases of its kind. <strong>More than 42,000 new GC-MS spectra</strong> representing <strong>34,100 compounds </strong>have been added, with data from laboratories, world patents and peer-reviewed scientific literature. Each spectrum is validated to the same rigorous standard, ensuring that the data perform reliably whether a researcher is running a manual comparison or feeding it into an automated identification pipeline.</p><p>The Wiley Registry is part of Wiley’s growing portfolio of scientific data and research intelligence solutions, which includes spectral databases, chemistry and materials literature, and analytical tools designed to support researchers and organizations from discovery through to applied outcomes. Wiley spectral database solutions are trusted by the world’s top pharmaceutical companies and many Fortune 500 organizations—reflecting Wiley’s mission to transform knowledge into actionable intelligence, equipping researchers with the rigorous reference data that drives real-world scientific discovery.</p><p><strong>Updated every three years,</strong> the Wiley Registry is among the company’s longest-standing data products, with a history spanning decades of continuous development.</p><p>“<i>The Wiley Registry is a foundational layer of intelligence for any laboratory conducting GC-MS analysis—and increasingly, for the AI-assisted workflows being built around that analysis</i>,” said Armughan Rafat, Wiley senior vice president and chief AI &amp; data analytics officer. “<i>By expanding compound coverage and applying consistent quality measures across the collection, we help analysts provide a deterministic layer to move from unknown to identified faster.</i>”</p><p>Available in the most common instrumentation manufacturer formats, the Wiley Registry of Mass Spectral Data 2026 also offers bundled options to access even more data with its <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/885"><strong>Wiley Registry/NIST</strong></a> and the <strong>KnowItAll GC-MS Library collection</strong> for labs seeking the most comprehensive coverage and workflow integration. The Wiley Registry is also available as a KnowItAll subscription for continued access to new data as they are added to the collection.</p><p>Spectral databases contain detailed “<strong>fingerprints</strong>” of substances captured through analytical techniques such as <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/934"><strong>mass spectrometry (MS)</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1271"><strong>Raman spectroscopy</strong></a>, enabling researchers to identify unknown materials by comparing their spectral signatures against validated reference spectra. This data is essential for quality control, research verification and discovery across industries from pharmaceuticals to materials science.</p><blockquote><p>For more information about the Wiley Registry of Mass Spectral Data 2026, please <a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/solutions/technique/gc-ms/wiley-registry-of-mass-spectral-data/"><strong>visit this website</strong></a>.</p></blockquote><h4><strong>About Wiley</strong></h4><p>Wiley (NYSE: WLY) is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&amp;D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning. Visit us at Wiley.com.</p>

Wiley releases the 2026 edition of the Wiley Registry of Mass Spectral Data to expand GC-MS identification intelligence

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Thermo Scientific™ EA IsoLink™ IRMS System

With the Thermo Scientific™ EA IsoLink™ IRMS Platform, leverage familiar technology and existing expertise for expanded CNSOH isotope analysis, allowing all elemental analysis on a single platform.

<h3><strong>All your elemental analysis on one platform</strong></h3><p><strong>The EA IsoLink IRMS Platform leverages the existing technological platform of the EA IsoLink IRMS System and FlashSmart EA.</strong></p><h4><strong>More freedom. More flexibility.</strong></h4><p>With the<strong> Thermo Scientific™ EA IsoLink™ IRMS Platform</strong>, you can leverage familiar technology and your staff’s existing know-how for <strong>expanded CNSOH isotope analysis</strong>, enabling you to perform all your elemental analysis on one technological platform. With <strong>different configurations</strong> to choose from, your lab can get the capabilities it needs today, with flexibility for the future. Featuring software- driven automation and scalability to grow as you do.</p><h4><strong>Choose the configuration that’s right for you.</strong></h4><p>The<strong> EA IsoLink IRMS</strong> System is an automated, easy-to-use solution for <strong>isotopic analysis of carbon, nitrogen, sulfur, oxygen and hydrogen</strong> - using bulk samples powered by chromatography-driven technology with high sensitivity on small samples. Available in basic configurations with upgradeability options, this platform offers high throughput and unattended operation, so your lab can get more done in less time.</p><h4><strong>The EA IsoLink IRMS System features:</strong></h4><ul><li><strong>Thermo Scientific™ Flash™ IRMS EA</strong> for sample preparation for IRMS analysis</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2231"><strong>Thermo Scientific™ ConFlo IV</strong></a> Universal Interface</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2232"><strong>Thermo Scientific™ DELTA™ Q IRMS</strong></a></li></ul><h4><strong>The FlashSmart EA features:</strong></h4><ul><li><strong>Thermo Scientific™ FlashSmart™ EA</strong> for weight percentage characterization of CNSHO</li></ul><h3><strong>EA IsoLink CN and CN/OH</strong></h3><ul><li>A powerful solution for <strong>C and N, O and H analysis</strong> - upgradeable for <strong>S analysis</strong></li></ul><h3><strong>EA IsoLink OH</strong></h3><ul><li>Offering dedicated<strong> oxygen and hydrogen analysis </strong>- with scalability to expand your capabilities to <strong>C, N and S</strong></li></ul><h3><strong>EA IsoLink CNSOH</strong></h3><ul><li>A fully automated single system for <strong>C, N and S analysis </strong>by flash combustion, and <strong>O and H analysis</strong> by high temperature conversion</li></ul><h4><strong>Connectivity with Thermo Scientific™ IRMS Portfolio</strong></h4><p>The <strong>Flash EA Series</strong> connected to the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2232"><strong>DELTA Q IRMS</strong></a><strong> </strong>provides precise and sensitive measurement of the isotope fingerprints - <strong>C, N, S, O and H isotopes </strong>- a unique chemical signature of samples. This helps you gain unique insights into food history and origin, as well as environmental pollutants, forensics and geosciences.</p><figure class="image"><img style="aspect-ratio:650/552;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_EA_Iso_Link_IRMS_System_2_01d3ed421c.jpg" alt="Thermo Scientific™ EA IsoLink™ IRMS System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_EA_Iso_Link_IRMS_System_2_01d3ed421c.jpg 184w," sizes="100vw" width="650" height="552"></figure><h3><strong>More automation. More scalability. All in a single platform.</strong></h3><p><strong>Delivering proven performance with unprecedented robustness and ease of use, the EA IsoLink IRMS Platform can help your lab drive efficiency, improve cost-effectiveness, and minimize training for new operators.</strong></p><h4><strong>Low cost per sample for reduced operational costs</strong></h4><p><strong>Less helium consumption:</strong> Helium consumption is reduced by more than 60% for NCS and NC sample analysis, and reduced by more than 30% for OH sample analysis (compared with previous systems).</p><p><strong>Less replication:</strong> Because the EA IsoLink IRMS System measures high and low concentrations in the same sample (wide dynamic range), it reduces the need for replicate analysis (e.g., high carbon and low sulfur, such as in food authenticity or ecology applications).</p><p><strong>High throughput:</strong> Fast analysis provides high sample throughput, resulting in lower cost per sample.</p><h4><strong>High sensitivity driven by chromatography - even for the smallest sample size</strong></h4><p><strong>Temperature-ramped GC:</strong> Equipped with a temperature-ramped GC feature, the EA IsoLink System gives your lab the highest performance on small sample sizes through optimal baseline separation of analyte gases and sharp peak shapes.</p><p><strong>Performance synergies:</strong> The combination of in-line flash combustion technology and temperature-ramped GC separation significantly improves the performance for all your EA-IRMS applications.</p><h4><strong>System modularity for future-proof investment</strong></h4><p>The <strong>EA IsoLink IRMS</strong> System’s modular design provides the highest flexibility for all applications - enabling you to <strong>adapt and scale</strong> to new analyses in the future. Through smart upgrade paths, you can easily modify the system to increase performance and productivity as your needs grow over time. Boost your CN system with an S upgrade or add CNS to your OH isotope fingerprints.</p><p><strong>Thermo Scientific™ MAS Plus Autosampler</strong> provides a 125-position helium-purged sample chamber, low blank autosampler for CNS and OH analysis.</p><p><strong>Thermo Scientific™ AS 1610 Liquid Autosampler</strong> offers a versatile solution for injecting liquid samples.</p><p>Macro reactors enable CNS Analysis of large sample sizes (greater than 60 mg) and higher throughput on standard sample sizes to mg range.</p><h4><strong>Added flexibility with flash EA series</strong></h4><p>The flexibility of the Flash EA Series helps you meet growing analytical needs in<strong> IRMS and Organic Elemental Analysis</strong> (OEA).</p><p>The <strong>FlashSmart Elemental Analyzer</strong> for OEA delivers accuracy and precision with internationally recognized certifications. Its straightforward modular design offers a variety of optimized application configurations, including <strong>CHN, CHNS, S, N/Protein, CN, CNS, CHNS/O and more</strong>. High throughput with <strong>24/7</strong> operation, low cost per sample and optimized helium consumption are all driven by our fully automated dedicated OEA software, Thermo Scientific™ EagerSmart™ Data Handling Software, which can grow with your analytical needs without need for an upgrade.</p><h4><strong>Smart automation for ease of use</strong></h4><p>Because of its <strong>intelligent software</strong> and intuitive design, the EA IsoLink Platform allows operators to leverage familiar technology for higher productivity.</p><p><strong>Software Platform: </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>The Thermo Scientific™ Qtegra™ Intelligent Scientific Data Solution</strong> </a>(ISDS) Software provides seamless control and automation for unattended operation and improved productivity. Regardless of operator skills or the final application, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>Qtegra ISDS Software</strong></a> offers logical, streamlined interface allowing straight forward measurement set-up through analytical Workflows. The software includes auto-stop, standby modes, and other features to minimize intervention. It also allows for integrated data evaluation strategies, customized reports and method development. All of the auto-diagnostics ensure important aspects of the instrument are monitored, maximizing uptime.</p><p><strong>Thermo Scientific™ smartEA option:</strong> This option allows you to focus on your research by combining ease-of-use and unattended analysis to deliver high-precision results. The smartEA option uses the analyzer’s <strong>Thermal Conductivity Detector </strong>(TCD) trace to define the required sample dilutions in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2231"><strong>ConFlo IV Universal Interface</strong></a>. The straightforward automated workflow allows you to analyze very small amounts, such as nitrogen and sulfur, along with highly abundant elements, such as carbon - all from the same sample.</p><h3><strong>Addressing a world of applications</strong></h3><p><strong>For origin and authenticity questions, the EA IsoLink IRMS Platform provides precise and sensitive measurement of the isotope fingerprints - C, N, S, O and H isotopes - a unique chemical signature of samples, helping you gain unique insights into their history and origin.</strong></p><h4><strong>Food authenticity and origin</strong></h4><p><strong>Is the label declaration on my food correct?</strong></p><p>From fruits and vegetables, to wine, honey and coffee, the EA IsoLink IRMS Platform provides isotopic fingerprints ideally suited to determining food integrity.</p><ul><li>Food adulteration</li><li>Food and beverage origin</li><li>Agronomy</li></ul><h4><strong>Environmental</strong></h4><p><strong>What is the source of pollution in the soil, water or air?</strong></p><p>An assessment of individual organic pollutants particles in air contamination (e.g. PM2.5) will be traced with C, N, and S isotope fingerprints.</p><ul><li>Marine science</li><li>Ecology and biology</li><li>Petroleum and exploration</li></ul><h4><strong>Geosciences</strong></h4><p><strong>What was the weather like thousands of years ago?</strong></p><p>By analyzing materials such as sediments, ice cores and speleothems, researchers can understand epochal changes in vegetation, rainfall patterns and temperature.</p><ul><li>Soil science</li><li>Palaeoclimatology research</li></ul><h4><strong>Forensics</strong></h4><p><strong>How can we investigate provenance and dietary preferences?</strong></p><p>From tracing explosives, illegal drugs, counterfeit currency, animal tissues such as ivory, dietary preferences and crime scene evidence, forensic investigations based on isotope fingerprints examine samples’ origin.</p><ul><li>Archaeology</li><li>Provenance</li></ul><h3><strong>Connectivity for origin and authenticity</strong></h3><p>Your lab can focus on isotopic investigations by taking advantage of having one partner and one platform for your elemental and isotope analysis. Thanks to the connectivity of the<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2232"><strong>DELTA Q IRMS</strong></a> and the connecting peripherals that are fully controlled by the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>Qtegra ISDS Software</strong></a>, you can also leverage the high throughput, unattended operation and flexibility for demanding analysis, regardless of the applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_EA_Iso_Link_IRMS_System_2_dcb8a3d338.jpg" alt="Thermo Scientific™ EA IsoLink™ IRMS System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_EA_Iso_Link_IRMS_System_2_dcb8a3d338.jpg 245w," sizes="100vw" width="1464" height="933"></p>

Thermo Scientific Triton Series Multicollector Thermal Ionization Mass Spectrometer (TIMS)

High-precision multicollector TIMS for demanding isotope ratio analysis, delivering exceptional sensitivity, stability, and accuracy for ultra-small and low-abundance samples.

<p><strong>The Thermo Scientific™ Triton™ Series Multicollector Thermal Ionization Mass Spectrometer (TIMS) is a high-precision platform designed for the most demanding isotope ratio measurements. Built on more than two decades of continuous development, the Triton Series combines field-proven TIMS performance with state-of-the-art detection and ion-optical technologies to deliver exceptional accuracy, stability, and sensitivity—especially for small samples and low-abundance isotopes.</strong></p><p>At the heart of the Triton Series is a <strong>high-stability thermal ionization source</strong>, optimized for maximum ion transmission and minimal kinetic energy spread. This ensures highly reproducible ion beams for both single- and double-filament techniques, enabling precise isotope ratio analysis across a wide range of elements and applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Triton_Series_Multicollector_Thermal_Ionization_Mass_Spectrometer_TIMS_2_e9fa5e958e.jpg" alt="Thermo Scientific Triton Series Multicollector Thermal Ionization Mass Spectrometer (TIMS)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Triton_Series_Multicollector_Thermal_Ionization_Mass_Spectrometer_TIMS_2_e9fa5e958e.jpg 182w," sizes="100vw" width="650" height="558"></p><h3><strong>Advanced detection and ion optics</strong></h3><p>The Triton Series integrates multiple complementary detector technologies to address diverse analytical challenges:</p><ul><li><strong>10¹³ Ω Amplifier Technology</strong> extends the lower detection limits, delivering faster response times, extremely low noise, and significantly improved internal precision for small ion beams.</li><li><strong>Retarding Potential Quadrupole (RPQ) lenses</strong> provide exceptional abundance sensitivity by suppressing scattered ions and mass tailing, enabling accurate quantification of minor isotopes even next to intense ion beams.</li><li><strong>Multi Ion Counting (MIC) packages</strong> allow simultaneous detection of the lowest-intensity ion beams using SEM and CDD ion counters, with flexible configurations tailored to nuclear, geochronological, and geochemical applications.</li><li><strong>Stable, linear SEM and CDD ion counters</strong> ensure reliable measurements for ultra-low sample amounts and rare isotopes.</li><li><strong>High-performance Faraday cups</strong> guarantee uniform response, long operational lifetime, and excellent linearity for high-precision static and dynamic measurements.</li><li><strong>Movable multicollector array</strong> supports up to nine Faraday cups with precise alignment over a wide mass range, extendable to static Ca and Li isotope measurements.</li><li><strong>Virtual amplifier technology</strong> enables cancellation of gain factor uncertainties through amplifier rotation, achieving low-ppm external reproducibility in efficient static measurement modes.</li></ul><h3><strong>Designed for the most demanding isotope ratio applications</strong></h3><p>The Triton Series is ideally suited for applications where ultimate precision and high abundance sensitivity are essential, including:</p><ul><li>Radiogenic and stable isotope geochemistry</li><li>Geochronology (U–Pb, Pb–Pb, Rb–Sr, Sm–Nd, Lu–Hf systems)</li><li>Nuclear safeguards and nuclear forensic isotope analysis</li><li>Environmental and cosmochemical research</li><li>Analysis of ultra-small sample amounts and isotopically scarce materials</li></ul><p>Available in configurations such as <strong>Triton XT</strong> and <strong>Triton Plus</strong>, tailored to different performance priorities within high-precision isotope ratio analysis, the Thermo Scientific Triton Series TIMS offers a flexible, future-proof solution that continues to set the benchmark for thermal ionization mass spectrometry.</p>

Thermo Scientific ConFlo IV Universal Continuous Flow Interface

Universal continuous flow interface for IRMS enabling automated multi-device control, higher throughput, lower costs, and stable, unattended isotope analysis.

<p><strong>Thermo Scientific™ ConFlo IV Universal Continuous Flow Interface is a versatile continuous flow interface designed to significantly expand the application range of stable isotope laboratories using isotope ratio mass spectrometry (IRMS). The ConFlo IV system enables seamless connection of multiple sample preparation devices, delivering fully automated, stable, and highly reproducible measurements.</strong></p><p>The system features <strong>intelligent management of all required reference gases, automatic sample-size recognition, precise matching of sample and reference signals, and advanced self-diagnostics</strong>. These capabilities reduce operator involvement, lower operating costs, and increase overall laboratory throughput.</p><h3><strong>Key features</strong></h3><ul><li><strong>Management of multiple devices</strong><br>Automated switching between different sample preparation units, including activation, deactivation, and reference gas changes, maximizes IRMS utilization.</li><li><strong>Continuous, unattended operation</strong><br>Application switching can occur at any time without operator intervention; preparation devices can be regenerated and reloaded while other analyses are running.</li><li><strong>Maximized performance and efficiency</strong><br>Using reference gases instead of bulk reference materials reduces operating costs by nearly 50 % while increasing sample throughput by almost 50 %.</li><li><strong>Enhanced accuracy and stability</strong><br>Automatic adjustment of reference gas pulse intensities equalizes conditions between sample and reference gases, improving precision and long-term reliability.</li><li><strong>Advanced data quality control</strong><br>Critical system parameters affecting data quality are automatically monitored across all sample sequences.</li><li><strong>Single-interface control</strong><br>All connected preparation and inlet devices are controlled through one interface, with the ability to add new samples or entirely new applications without interrupting ongoing data acquisition.</li></ul>

Thermo Scientific DELTA Q Isotope Ratio Mass Spectrometer

High-performance IRMS combining exceptional sensitivity, robust design, and intuitive Qtegra ISDS software for food authenticity, environmental, forensic, and research isotope applications.

<p><strong>The Thermo Scientific™ DELTA™ Q Isotope Ratio Mass Spectrometer (IRMS) represents a new evolutionary step in isotope ratio analysis, combining outstanding analytical performance with intuitive operation powered by </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489"><strong>Qtegra™ Intelligent Scientific Data Solution (ISDS)</strong></a><strong> software.&nbsp;</strong></p><p>The DELTA Q IRMS is designed for seamless integration with a wide range of Thermo Scientific peripherals, making it a highly flexible platform for applications such as <strong>food authenticity testing, environmental and forensic analysis, doping control, and advanced scientific research</strong>.</p><h4><strong>Outstanding sensitivity</strong></h4><ul><li>Sensitivities of up to <strong>800 molecules per CO₂ ion</strong> in dual-inlet mode and <strong>1,000 molecules per ion</strong> in continuous-flow mode.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DELTA_Q_Isotope_Ratio_Mass_Spectrometer_2_671e47510f.jpg" alt="Thermo Scientific DELTA Q Isotope Ratio Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DELTA_Q_Isotope_Ratio_Mass_Spectrometer_2_671e47510f.jpg 197w," sizes="100vw" width="650" height="517"></p><h4><strong>Versatility for diverse applications</strong></h4><ul><li>Support for up to <strong>10 collectors</strong> in multiple configurations, covering all IRMS applications up to <strong>m/z 96</strong>.</li><li><strong>Simultaneous mass range up to ±25%</strong>, enabling efficient multi-isotope measurements.</li><li>Compatibility with <strong>preconcentrators, elemental analyzers, GC interfaces, LC interfaces</strong>, and continuous-flow inlets.</li><li><strong>On-line H₂ capability</strong> for hydrogen isotope analysis.</li></ul><h4><strong>Highly robust and reliable design</strong></h4><ul><li>A <strong>monolithic analyzer</strong> with fixed alignment of all ion-optical components, including the electromagnet, ensuring exceptional long-term stability and robustness.</li><li>Integrated signal amplifiers and digitizers minimize external connections and increase reliability.</li><li>Fixed-position ion optics eliminate the need for realignment during installation or routine maintenance.</li><li>Optimized pumping strategy enables <strong>single-stage turbo pumping</strong> for all standard continuous-flow applications.</li><li>Comprehensive, automated diagnostics driven by <strong>Qtegra ISDS software</strong> support continuous performance monitoring.</li></ul><h4><strong>Compact and user-friendly design</strong></h4><ul><li>Compact footprint requiring minimal laboratory space.</li><li>Dedicated space for online peripherals on top of the instrument.</li><li>Dual inlet, µ-volume, and multiport interfaces are neatly integrated inside the system.</li><li>Continuous-flow interfaces can be fully controlled from the front panel.</li><li>All pumps are located internally, reducing noise and laboratory clutter.</li></ul><h4><strong>Qtegra™ ISDS Software</strong></h4><ul><li>Significantly increases laboratory productivity with <strong>automatic Get Ready functionality</strong>, ready-to-use templates, and built-in quality control tools.</li><li>Intelligent, optimized workflows guide users from sample to result while allowing flexible switching between system configurations.</li><li>Ensures full <strong>data integrity and traceability</strong> for raw data, metadata, and reported results.</li></ul><h4><strong>ACT label certification</strong></h4><p>The DELTA Q IRMS is certified with the <strong>ACT Environmental Impact Label</strong> from My Green Lab, providing transparent, third-party verified information on environmental impact across manufacturing, energy and water use, packaging, and end-of-life considerations—supporting sustainable laboratory procurement and reduced carbon footprint.</p>

Products from category IRMS focused on GC/MSD - page 1

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