<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 6th April 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, BaySpec, </strong>poster by <strong>MDCW / William &amp; Mary </strong>and<strong> </strong>brochure by<strong> Shimadzu!</strong></p><h3><strong>1. Agilent Technologies: High-Throughput BTEX Analysis in Nail Products by SPME and GC/TQ</strong></h3><p><strong>Minimal steps, maximum precision</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_btex_analysis_nail_products_spme_gctq_5994_9009en_agilent_24ef32dd13.pdf"><strong>Full PDF for download</strong></a></li></ul><p>BTEX compounds—benzene, toluene, ethylbenzene, and xylenes—are volatile aromatic hydrocarbons widely used as solvents in industrial and consumer products. Among these, toluene is the most prevalent in nail polish formulations, where it serves as a solvent to dissolve resins and pigments, ensuring smooth application, uniform color dispersion, and rapid drying. Historically, these properties made toluene a preferred ingredient in nail coatings, including traditional polishes, gel formulations, and nail art products. However, its inclusion presents challenges for regulatory compliance and product reformulation. In response to these challenges, the California Department of Toxic Substances Control (DTSC) has listed nail products containing toluene as Priority Products under the Safer Consumer Products Regulations.1 Manufacturers selling such products in California must submit a Priority Product Notification and conduct an Alternative Analysis if toluene concentrations exceed the 100-ppm threshold.&nbsp;</p><p>To support compliance and ensure accurate monitoring of BTEX levels in nail products, robust analytical methods are essential. Solid phase microextraction (SPME) coupled with gas chromatography/triple quadrupole mass spectrometry (GC/TQ) has emerged as a preferred approach for volatile organic compound analysis due to its solvent-free sample preparation, high sensitivity, and compatibility with complex cosmetic matrices. The 8890 GC with 7000 Series GC/TQ offers enhanced detection capabilities through dynamic multiple reaction monitoring (dMRM), enabling precise quantification of BTEX compounds at trace levels, below regulatory thresholds. This platform provides the analytical rigor required for method validation, including limits of detection, recovery, and precision, ensuring compliance with California's stringent performance criteria and supporting industry efforts toward improving consumer product&nbsp;quality.&nbsp;</p><h4><strong>Experimental</strong></h4><h5><strong>GC/TQ analysis&nbsp;</strong></h5><p>Analyses were performed on an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890+GC"><strong>8890 GC</strong></a> coupled to a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7000"><strong>7000 Series GC/TQ </strong></a>equipped with an EI extractor ion source (Figure 2). The instrument operating parameters are listed in Table 2. The system was operated in splitless mode with an inlet temperature of 200&nbsp;°C, a purge flow of 3 mL/min, and a purge flow to split vent of 50&nbsp;mL/min at 2&nbsp;minutes. Carrier gas was helium at a constant flow of 0.693&nbsp;mL/min with a total flow of 53.7 mL/min. The chromatographic separation was accomplished on an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=DB-624+Ultra+Inert+column"><strong>Agilent J&amp;W DB-624 Ultra Inert column</strong></a> (20&nbsp;m × 0.18&nbsp;mm, 1&nbsp;µm, part number 121-1324UI). The oven program started at 40&nbsp;°C (hold 2&nbsp;minutes), ramped at 35&nbsp;°C/min to 160&nbsp;°C, and held for 2.58&nbsp;minutes, giving a total run time of 8.0&nbsp;minutes. The transfer line was maintained at 230&nbsp;°C, with the ion source at 230&nbsp;°C and quadrupoles at 150&nbsp;°C.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>A rapid, high-throughput headspace‑SPME GC/TQ method was developed for quantifying BTEX in nail product matrices, using a 100-µm PDMS Agilent Smart SPME fiber on an Agilent 8890 GC with Agilent 7000 Series GC/TQ. The method provides solvent-free extraction, 8-minute chromatographic runs, and an ~11-minute total cycle time, enabling high-throughput analysis with robust selectivity in dMRM mode. Quality control results demonstrated mean recoveries of 100 to 107% with RSDs ≤ 8%, meeting method acceptance criteria for compliance-focused testing for toluene. Integration of Smart SPME automation and the intelligent features of the 8890 GC and 7000 Series GC/TQ allows a practical, defensible solution for routine laboratories monitoring BTEX in nail products. Calibration performance showed high linearity and low variance across the working ranges, with all compounds meeting initial calibration criteria via R² ≥ 0.995 or average RF RSD ≤ 20%. Combined with the short cycle time and automated fiber tracking, this workflow is ideally suited for routine compliance testing of BTEX in nail products using the 8890 GC and 7000&nbsp;Series GC/TQ.</p><h3><strong>2. BaySpec: Detection of residual pesticides on fruits and vegetables using Portability miniature mass s pectrometer</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Bay_Spec_App_Note_Portability_Pesticides_4a7311fb3e.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Pesticides are used in a variety of different ways during the production of food. Ranging from preventing crop damage by insects, rodents and molds during growth to prolonging storage of food after harvest. Because of the frequent usage, the residual pesticides are often found in many agricultural products and their monitoring and control is an important step in achieving and maintaining overall food safety in the modern society.&nbsp;</p><p>Mass spectrometry in connection with different separation techniques currently represents the main analytical approach for determination of residual pesticides in food. Traditionally, samples need to be collected and send to a laboratory for analysis using techniques such as GC-MS or HPLC-MS, which are costly and time-consuming. In addition, the conventional mass spectrometry usually requires laborious sample pretreatment, which does not allow for immediate in-situ sample determination. Presented here is an application of Thermal Desorption ElectroSpray Ionization (TD-ESI) for pesticide screening coupled to a portable mass spectrometer.&nbsp;</p><p>TD-ESI is a mass spectrometry technique from the family of ambient ionization methods that utilizes very simple probing of different surfaces with no or limited sample pretreatment while it is still noted for its selective and sensitive detection capabilities. In TD-ESI a solid surface or a liquid sample is touched by a simple metallic probe that absorbs the analyte. The probe is then inserted into a heated tube and the desorbed analyte is carried by gas flow into an orthogonally mounted electrospray. The electrospraty plume extracts the analyte and further ionization and ion introduction follows the conventional electrospray mechanism.&nbsp;</p><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2219"><strong>Bayspec’s Portability mass spectrometer</strong></a> is less than 10kg highly portable and battery operated linear ion trap mass spectrometer with atmospheric pressure inlet (API). When TD-ESI is combined with PortabilityTM then it is possible to perform fast in-field detection of analytes including residual pesticides, directly of the surfaces of fresh food products without any sample pre-treatment. Fast pesticide screening by Portability mass spectrometer can immediately disclose fake organic food products as well as to discover elevated levels of residual pesticides.&nbsp;</p><p>TD-ESI-MS was used to rapidly screen residual pesticides on the surfaces of different fruits and vegetables. Direct sampling probe was used to introduce analytes from surfaces of unprocessed samples. Due to short analysis times (1-5s a sample), the technique allows for fast screening for applications in food and environmental safety. MS (as well as MS/MS) analyses can be performed on surface-residual pesticides at ppm and sub-ppm levels. The miniaturized TD-ESI ion source compatible with Portability is available from BaySpec. This ion source mounts on the Portability front inlet and does not require any additional support, external power or gases. The simple intuitive software interface is operated by touch screen and makes the instrument extremely easy to control. The external TD-ESI source is fully integrated into the main software environment and the hyphenated system is thus very user-friendly, does not require excessive training and can be operated by persons with no previous mass spectrometry experiences.</p><h3><strong>3. MDCW / William &amp; Mary: Volatile Characterization of American Foulbrood Disease Using Comprehensive Two-Dimensional Gas Chromatography</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_15_Christensen_39521e3391.pdf"><strong>Full PDF for download</strong></a></li></ul><p>American foulbrood (AFB) is a deadly disease spread by Paenibacillus larvae bacterial spores, targeting the brood stage of Apis mellifera honey bees. Broods perish in a matter of days after exposure to the spores, forming infected colloidal scales in the hive that adult bees cannot remove. 1,2 The spores are extremely persistent and resistant to typical treatment methods, which standardized the immediate euthanasia of bees and destruction of the hive and associated equipment by burning. 3 In an effort to expedite identification of the spores, scent-detection dogs have been trained for use in apiaries. Furthermore, gammairradiation has been tested as a proposed treatment method as it would offer a nondestructive alternative to sterilization.</p><p>The goals of this study were to use comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC×GC-TOFMS) to characterize the volatiles associated with AFB disease for understanding scent detection and to measure the effectiveness of gamma-irradiation in sterilizing these volatiles.</p><h4><strong>Methods</strong></h4><p>Samples included blanks, material from healthy comb, aged unsterilized diseased scales, fresh unsterilized diseased scales, and diseased scales sterilized with the proposed treatment method of gamma-irradiation. These samples were stored in headspace vials (Figure 3) in the freezer when not in use. No sample preparation was required before injection with solidphase microextraction using the LPAL-3 (CTC Analytics).</p><p>Analysis was performed using a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37"><strong>Pegasus BT4D</strong></a> (LECO Corporation) according to the parameters described below in Table 1. <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/41"><strong>ChromaTOF software</strong></a> (LECO Corporation) was used to analyze the chromatographic data. Preliminary identifications were assigned to peaks using a minimum signal to noise of 200 and a minimum stick count of 3.</p><h4><strong>Conclusions</strong></h4><p>GC×GC-TOFMS can be used to distinguish the volatile profiles of A. mellifera samples at different stages of infection with AFB disease. Future Directions for Research:&nbsp;</p><ul><li>Discrimination of volatiles specific to AFB from non-specific volatiles&nbsp;</li><li>Characterization of AFB-specific volatiles for scent-detection purposes&nbsp;</li><li>Measurement of gamma-irradiation sterilization success in removing AFB volatiles</li></ul><h3><strong>4. Shimadzu: Screening System for Phthalate Esters, Brominated Flame Retardants and Other Regulated Substances Py-Screener Ver.3</strong></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c146_e507_45f041b0d7.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Py-Screener"><strong>Py-Screener™ Ver. 3</strong></a> can screen for 7 types of phthalate esters and brominated flame retardants (PBBs, PBDEs), including substances regulated under the RoHS Directive. In addition, it can also test for PIP (3:1), which is regulated under the US TSCA (Toxic Substances Control Act), as well as UV-328, Dechlorane Plus (DP), and short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs), which are regulated under the Stockholm Convention (POPs Convention) on Persistent Organic Pollutants (POPs). These regulated compounds, thermally extracted from the sample by Pyrolysis-GC-MS (Py-GC-MS), are selectively detected and quantified. Py-Screener Ver. 3 consists of dedicated software for easy screening, special standard samples, and a sampling tool kit, making it simple to operate even for first-time users.</p><h5><strong>Shimadzu Corporation’s Solutions for Complying with International Hazardous Substance Regulations</strong></h5><p>When manufacturing and exporting products, it is necessary to comply with the chemical and hazardous substance regulations established by each country. Products contain many parts and use various materials and substances. Therefore, it is the manufacturer’s responsibility to manage the entire supply chain to ensure that harmful substances are not contained. Shimadzu Corporation provides analysis solutions that comply with these regulations.</p><h5><strong>Applicable Systems and Software</strong></h5><ul><li><strong>GC-MS: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2020+NX"><strong>GCMS-QP™2020 NX</strong></a>, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2020"><strong>GCMS-QP2020,</strong></a> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2010+Ultra"><strong>GCMS-QP2010 Ultra</strong></a></li><li><strong>Pyrolyzer:</strong> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=42&amp;search=EGA%2FPY-3030D"><strong>EGA/PY-3030D</strong></a> multi-shot pyrolyzer</li><li><strong>Autosampler:</strong> AS-2020E, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=42&amp;search=AS-1020E"><strong>AS-1020E auto-shot sampler&nbsp;</strong></a></li><li><strong>GC-MS Workstation:</strong> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMSsolution"><strong>GCMSsolution</strong></a>™ (Ver. 4.60SP2 or later) + <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=LabSolutions+Insight"><strong>LabSolutions Insight</strong></a>™ (Ver. 5.0 or later)</li><li><strong>Py Workstation:</strong> EGA-PY3030 program (Ver. 1.54 or later)</li></ul>

News from LabRulezGCMS Library - Week 15, 2026

Microplastics and Nanomaterials: Understanding Emerging Contaminants in Environmental Testing

<div><div><div><p><strong>Our immune system is incredibly powerful: among other things, it can recognize and destroy cancer cells. But tumors can be just as effective at avoiding detection – they build “invisibility shields” to protect themselves from attack.</strong></p></div></div><div><p>One breakthrough in cancer therapy has been immune checkpoint inhibitors (ICIs), drugs that reactivate immune T cells and help them fight tumors again. However, only about 20–50% of patients respond well to this treatment. Researchers are therefore seeking alternative therapeutic strategies. A small and well-known molecule called adenosine plays a key role in these efforts.</p><p>When tumor cells are stressed or dying, they release ATP, which is normally a signal that something is wrong in the tissue. But in the tumor microenvironment, ATP gets rapidly broken down by two enzymes, CD39 and CD73. Released adenosine acts like a chemical “calm-down” signal, binds to immune cells (T cells, NK cells, and others), and tells them to slow down, reducing their ability to kill cancer cells. Targeting CD73 therefore represents a promising strategy for developing new cancer treatments.</p></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg" alt="IOCB Prague: Development of potent inhibitors to boost the immune system's ability to fight cancer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg 245w," sizes="100vw" width="661" height="363"></p><p>At IOCB Prague, interdisciplinary teams led by Jan Řezáč, Jan Konvalinka, and Michal Hocek used a newly developed high-throughput screening method to test over 5,000 compounds, identifying two ribonucleoside derivatives as promising CD73 inhibitors.</p><p>The scientists then improved the compounds’ activity by carefully modifying the ribonucleoside scaffold with bulky (het)aryl groups. Further optimization improved the pharmacokinetic properties of these compounds, yielding inhibitors with low clearance, long half-life, high solubility, and strong selectivity over related enzymes such as CD39.</p><p>In cellular experiments, the compounds reduced adenosine production in cancer cells, restored T cell activation, and showed no toxicity toward human fibroblasts. The most active compound showed a single-digit picomolar inhibition constant (Ki).</p><p>These findings establish a strong foundation for further in vivo efficacy and combination studies, which will explore the therapeutic potential of this novel inhibitor class.</p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707"><strong>Potent Competitive Inhibitors of Ecto-5′-nucleotidase (CD73) based on 6-(Het)aryl-7-deazapurine Ribonucleoside 5′-O-Bisphosphonates</strong></a></h4><p>Ugnė Šinkevičiu̅tė, Magdalena Šímová, Radek Staník, Lenka Poštová Slavětínská, Kristýna Blažková, Pavel Šácha, Martin Lepšík, Jan Řezáč, Jan Konvalinka, Tereza Ormsby, Michal Tichý, Michal Hocek</p><p><i><span><strong>ACS Pharmacol. Transl. Sci.</strong></span></i><strong> </strong><span><strong>2026, 9, 1, 191–213</strong></span></p><p><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">https://pubs.acs.org/doi/10.1021/acsptsci.5c00707</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>CD73 generates immunosuppressive adenosine in the tumor microenvironment and is a promising target for cancer immunotherapy. We have designed and systematically studied diverse 2-substituted 7-deazapurine ribonucleoside 5′-<i>O</i>-bisphosphonates bearing a variety of (het)aryl groups at position 6 and discovered their highly potent and selective CD73 inhibition activity. The most active compounds (with single-digit picomolar <i>K</i><sub>i</sub>) contained bicyclic (het)aryl groups at position 6 in combination with chlorine at position 2. Further optimization of pharmacokinetic properties identified inhibitors with low clearance, long half-life, high solubility, and excellent selectivity over CD39 and NTPDase3. They effectively suppressed adenosine formation in MDA-MB-231 cells, rescued CD8<sup>+</sup> T cell activation, and were nontoxic to human fibroblasts. Overall, their profile compares favorably with <strong>AB680</strong>, a CD73 inhibitor currently in phase I/II clinical trials.</p></div>

Development of potent inhibitors to boost the immune system's ability to fight cancer

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Poster

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Thermo Scientific™ ISQ™ 7000 Single Quadrupole GC-MS System

Robust single quad GC-MS with advanced ion sources, NeverVent™ tech, SmartTune, and flexible software. Delivers sensitive, high-throughput routine analysis.

<h4><strong>Unstoppable GC-MS performance for routine, regulatory, and high-throughput analysis</strong></h4><p><strong>The ISQ 7000 GC-MS system delivers reliable, scalable, and ultra-sensitive performance for routine analysis in food safety, environmental, clinical, and forensic laboratories. Designed to maximize uptime and analytical confidence, it features advanced ion source options, easy maintenance with NeverVent™ technology, and intuitive software tools like SmartTune and AutoSIM.</strong></p><h3><strong>Key Features and Benefits</strong></h3><h4>🚀 <strong>Unstoppable Sensitivity</strong></h4><ul><li>Advanced Electron Ionization (AEI) source for femtogram-level detection</li><li>Robust ExtractaBrite™ ion source, fully removable under vacuum</li><li>Dual-filament design and S-shaped ion optics reduce neutral and chemical noise</li><li>Simultaneous full-scan and SIM acquisition modes</li></ul><h4>⚙️ <strong>Unstoppable Uptime</strong></h4><ul><li><strong>NeverVent™ technology</strong> with Vacuum Probe Interlock (VPI) and V-Lock for maintenance without venting</li><li>Heated ion optics and RF lens protect quadrupole from matrix contamination</li><li>Reliable quadrupole design: solid, non-coated rods and maintenance-free performance</li><li>Up to <strong>98% downtime reduction</strong> for routine interventions (e.g. source cleaning)</li></ul><h4>🧠 <strong>Smart Automation and Ease of Use</strong></h4><ul><li><strong>SmartTune</strong> for guided, fast, and consistent system tuning</li><li><strong>AutoSIM</strong> and <strong>Timed-SIM (t-SIM)</strong> for efficient method creation</li><li><strong>Retention Time Alignment (RTA)</strong> tool for consistent results across column changes</li><li>Deconvolution tools for untargeted compound identification</li></ul><h4>🧪 <strong>Flexible Analytical Capabilities</strong></h4><ul><li>EI, PCI, NCI ionization modes (with optional dual reagent gas switching)</li><li>Mass range: 1.2–1100 u; scanning speed up to 240 scans/s</li><li>Optional Direct Insertion and Direct Exposure probes for solid samples</li><li>Software-switchable ionization modes in a single analysis</li></ul><h4>🖥️ <strong>Integrated Software and Data Handling</strong></h4><ul><li>Full control via <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/76"><strong>Chromeleon™ CDS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/77"><strong>TraceFinder™</strong></a></li><li>Preloaded application libraries and eWorkflows (e.g. US EPA, clinical, toxicology)</li><li>Auto-calibration, QA/QC tools, and compliance-ready (21 CFR Part 11)</li><li>Seamless LIMS connectivity and user-guided reporting tools</li></ul><h4>🔁 <strong>Sample Introduction Options</strong></h4><ul><li>Compatible with <strong>AI/AS 1310</strong>, <strong>TriPlus 300</strong> (HS), and <strong>TriPlus RSH</strong> autosamplers</li><li>Robotic workflows including dilution, standard addition, and derivatization</li><li>Ideal for trace analysis in complex matrices and high-throughput environments</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/application::product.product/isq-7000-trace-1310-triplus-rsh-left-1200x1200.jpg-650_s.webp" alt="Thermo Scientific™ ISQ™ 7000 Single Quadrupole GC-MS System" width="382" height="382"></p>

Thermo Scientific ISQ™ 7610 Single Quadrupole GC-MS

Thermo Scientific ISQ™ 7610 Single Quadrupole GC-MS. Simplified operation, automated workflows, and extended dynamic range deliver consistent results from system to system in every laboratory.

<p><strong>To stay ahead, analytical testing laboratories need the ultimate confidence of a GC-MS system that easily and reliably produces trusted results, day after day. For this, you can count on the Thermo Scientific™ ISQ™ 7610 Single Quadrupole GC-MS System. Simplified operation, automated workflows, and extended dynamic range deliver consistent results from system to system in every laboratory. Thermo Scientific™ NeverVent™ technology, extended-life detector, and intelligent software eliminate unnecessary downtime to maximize sample throughput. To ensure you are ready for any analytical challenge, the system is upgradeable from entry-level to advanced configurations. Now you can take the lead with rapid return on investment (ROI) for your regulated GC-MS analyses.</strong></p><h4><strong>Unstoppable confidence in quantitative performance</strong></h4><p>Delivers femtogram-level sensitivity so you consistently meet required detection limits as you run samples, whether you run in SIM mode or Full Scan. The ISQ 7610 GC-MS features a unique ion path that neutral particles cannot navigate and a choice of an ExtractaBrite or AEI ion source, depending on your sensitivity needs. The instrument’s XLXR detector which is an electron multiplier detector has an extended lifetime and extended dynamic range. Extended dynamic range capability enables labs to combine methods allowing analysis of low- and high-concentration compounds in a single run.</p><h4><strong>The right choice for any workflow</strong></h4><p>The intuitive <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/chromatography/chromatography-data-systems-cds.html">Thermo Scientific Chromeleon Chromatography Data System (CDS)</a> is available to help streamline quantitative workflows and ready-to-use Thermo Scientific eWorkflows can be downloaded from the <a target="_blank" rel="noopener noreferrer" href="https://appslab.thermofisher.com/">Thermo Scientific Appslab Library of Analytical Applications</a> to jump-start your method development. For U.S. EPA-based environmental applications, the Environmental Analysis Extension pack provides a set of GC-MS e-workflow and reporting templates.</p><h4><strong>Unstoppable instrument uptime for full-time productivity</strong></h4><p>The robust design of the ISQ 7610 GC-MS ensures that the system can work continuously to produce the highest quality results possible. High matrix tolerance minimizes routine maintenance, but when maintenance is required, the NeverVent technology available with the ExtractaBrite ion source enables source cleaning, column replacement or injector maintenance without requiring downtime to vent the instrument, so more time can be spent producing results.</p><h4><strong>Ease of use that helps you stay ahead</strong></h4><p>Automated software for instrument tuning, method development, targeted quantification and untargeted screening workflows make the ISQ 7610 GC-MS system easy to learn and enables quick transition to this system from other platforms. The ISQ 7610 Single Quadrupole GC-MS System features user-centric innovations including instrument health monitoring assists you in determining when maintenance is needed to avoid unnecessary downtime. As a result, you maximize instrument utilization, sample throughput, and ultimately ROI.</p><h4><strong>Unstoppable confidence in your future</strong></h4><p>To ensure you are ready for any analytical challenge, the ISQ 7610 Single Quadrupole GC-MS System is fully upgradable from entry-level to advanced configurations. Now you can be confident that your laboratory can adapt to new challenges using the same investments in GC-MS technology.</p><h3><span><strong>Specifications</strong></span></h3><ul><li><span><strong>Mass Range: </strong>1.2–1100 u with unit mass resolution&nbsp;</span></li><li><span><strong>Type:&nbsp;</strong>Single Quadrupole GC-MS</span></li><li><span><strong>Detectors:&nbsp;</strong>Triple off-axis Thermo Scientific™ DynaMax™ XTEND XR detection system, with off-axis 10 kV dynode, discrete dynode electron multiplier and electrometer, linear from 0 to 110 μA</span></li><li><span><strong>Modes:&nbsp;</strong>Electron Impact Ionization (EI), with Full Scan (FS), SIM, and FS/SIM, Simultaneous within the same injection</span></li><li><span><strong>Scanning Capabilities:&nbsp;</strong>Fast Quadrupole Scanning up to 20,000 U/s</span></li><li><span><strong>Source Type:</strong>&nbsp;Advanced Electron Ionization (AEI) Source for Ultra-Sensitivity and Robustness</span></li><li><span><strong>Item Description:&nbsp;</strong>Scalable GC-MS platform, fully upgradable from a base configuration to an advanced highly sensitive configuration</span></li><li><span><strong>Description:</strong>&nbsp;ISQ 7610 Large Turbo, No VPI with AEI</span></li><li><span><strong>Mass Stability:&nbsp;</strong>Better than 0.1 u/48 hours/∆T ≤2 K</span></li><li><span><strong>Dimensions:</strong>&nbsp;46 x 36 x 69 cm (18 x 14 x 27 in) (H x W x D)</span></li><li><span><strong>Mass Analyzer:&nbsp;</strong>Dual-stage mass filter with off-axis ion guide pre-filter for noise reduction and solid, homogeneous non- coated, maintenance-free quadrupole rods</span></li></ul>

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