C1 – C3 amines - Analysis of impurities in trimethylamine
Applications | 2011 | Agilent TechnologiesInstrumentation
Gas chromatography analysis of C1–C3 amine impurities in trimethylamine ensures high chemical purity required for industrial and research applications.
Detecting mono- and di-methylamine traces prevents performance issues and safety concerns in downstream processes.
This study demonstrates a rapid GC-capillary method to separate and quantify methylamine impurities in bulk trimethylamine.
The goal is to achieve clear resolution of mono-, di-, and tri-methylamine within an 18-minute runtime.
The analysis employs an Agilent CP-Volamine fused-silica column (0.32 mm×60 m, WCOT) with helium as the carrier gas at 100 kPa.
The temperature program starts at 40 °C (10 min), ramps at 20 °C/min to 250 °C, with a split ratio of 1:50 in the injector held at 180 °C.
Detection is by flame ionization (FID) at 250 °C, using a 1 µL liquid injection of bulk trimethylamine.
The method resolves mono-methylamine, di-methylamine, and tri-methylamine peaks in under 18 minutes, with distinct retention times for each compound.
Peak identification confirms baseline separation and reproducible quantification suitable for quality control.
The procedure delivers fast turnaround, high sensitivity, and reliable impurity profiling for manufacturing and research laboratories.
Its straightforward setup and robust performance make it ideal for routine quality assurance of amine reagents.
Advances may include coupling to mass spectrometry for structural confirmation and trace-level detection.
Integration with automated sampling and data processing could further streamline high-throughput impurity screening.
This GC-capillary method provides an efficient, reproducible approach to separate and quantify methylamine impurities in trimethylamine, supporting stringent quality requirements.
GC, GC columns, Consumables
IndustriesEnergy & Chemicals
ManufacturerAgilent Technologies
Summary
Significance of the topic
Gas chromatography analysis of C1–C3 amine impurities in trimethylamine ensures high chemical purity required for industrial and research applications.
Detecting mono- and di-methylamine traces prevents performance issues and safety concerns in downstream processes.
Objectives and Study Overview
This study demonstrates a rapid GC-capillary method to separate and quantify methylamine impurities in bulk trimethylamine.
The goal is to achieve clear resolution of mono-, di-, and tri-methylamine within an 18-minute runtime.
Methodology and Instrumentation
The analysis employs an Agilent CP-Volamine fused-silica column (0.32 mm×60 m, WCOT) with helium as the carrier gas at 100 kPa.
The temperature program starts at 40 °C (10 min), ramps at 20 °C/min to 250 °C, with a split ratio of 1:50 in the injector held at 180 °C.
Detection is by flame ionization (FID) at 250 °C, using a 1 µL liquid injection of bulk trimethylamine.
Main Results and Discussion
The method resolves mono-methylamine, di-methylamine, and tri-methylamine peaks in under 18 minutes, with distinct retention times for each compound.
Peak identification confirms baseline separation and reproducible quantification suitable for quality control.
Benefits and Practical Application
The procedure delivers fast turnaround, high sensitivity, and reliable impurity profiling for manufacturing and research laboratories.
Its straightforward setup and robust performance make it ideal for routine quality assurance of amine reagents.
Future Trends and Potential Applications
Advances may include coupling to mass spectrometry for structural confirmation and trace-level detection.
Integration with automated sampling and data processing could further streamline high-throughput impurity screening.
Conclusion
This GC-capillary method provides an efficient, reproducible approach to separate and quantify methylamine impurities in trimethylamine, supporting stringent quality requirements.
References
- Agilent Technologies, Inc. C1–C3 amines: Analysis of impurities in trimethylamine. Application Note A01585; 2011.
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