Agilent 5977A Series GC/MSD System - Data Sheet
Brochures and specifications | 2014 | Agilent TechnologiesInstrumentation
The combination of gas chromatography (GC) with mass selective detection (MSD) has become a cornerstone technique in analytical chemistry for separating, identifying and quantifying complex mixtures. The Agilent 7890B/5977A Series GC/MSD system represents a mature and high-performance platform that addresses demanding applications in environmental analysis, forensics, food safety, pharmaceuticals and petrochemical research.
This data sheet presents the design features, performance specifications and software capabilities of the Agilent 7890B gas chromatograph coupled with the 5977A Mass Selective Detector. It aims to inform users about sensitivity, selectivity, stability and the range of detection modes available, as well as the system’s throughput and automation options.
The system delivers industry-leading signal-to-noise ratios and sub-femtogram detection limits (10 fg IDL for Extractor source). Mass axis stability is better than 0.10 u over 48 h. EI scan S/N ratios exceed 1,500:1 (Extractor source), while PCI and NCI modes achieve S/N of 125:1 and 600:1, respectively. With optional accurate mass software, mass accuracy reaches ±0.005 u and spectral accuracy exceeds 99%. The integrated instrument control and communication between GC and MSD enhance method development, autotuning and safety.
Key advantages include ultra-high sensitivity for trace analysis, versatile ionization modes for a broad compound range, rapid method development supported by software intelligence, and eco-friendly features that reduce energy consumption. The system is well suited for environmental monitoring, forensic toxicology, food contaminant screening, QA/QC workflows and research in semivolatile organics.
Advancements are expected in real-time data processing with machine learning, further miniaturization of GC/MS devices for field deployment, expanded accurate mass workflows, and deeper integration with laboratory automation. Emerging applications include untargeted metabolomics, comprehensive two-dimensional GC/MS and on-site environmental screening.
The Agilent 7890B/5977A GC/MSD system offers a robust, high-throughput solution with unmatched sensitivity and stability. Its combination of flexible ionization modes, advanced software and eco-efficient design positions it as a leading choice for demanding analytical laboratories.
Agilent Technologies Inc. Agilent 5977A Series GC/MSD System Data Sheet, Publication 5991-1838EN, June 3, 2014.
GC/MSD, GC/SQ
IndustriesManufacturerAgilent Technologies
Summary
Importance of the Topic
The combination of gas chromatography (GC) with mass selective detection (MSD) has become a cornerstone technique in analytical chemistry for separating, identifying and quantifying complex mixtures. The Agilent 7890B/5977A Series GC/MSD system represents a mature and high-performance platform that addresses demanding applications in environmental analysis, forensics, food safety, pharmaceuticals and petrochemical research.
Objectives and Overview of the Data Sheet
This data sheet presents the design features, performance specifications and software capabilities of the Agilent 7890B gas chromatograph coupled with the 5977A Mass Selective Detector. It aims to inform users about sensitivity, selectivity, stability and the range of detection modes available, as well as the system’s throughput and automation options.
Instrumental Methodology and Used Instrumentation
- Gas Chromatograph: Agilent 7890B with oven temperature range from ambient +4 °C to 450 °C, supporting up to 20 ramps and 21 plateaus.
- Mass Selective Detector: Agilent 5977A featuring an Extractor-type or inert EI source, optional PCI and NCI capabilities, with ion source temperatures of 150–350 °C and a monolithic hyperbolic quadrupole (mass range 1.6–1,050 u).
- Autosamplers: Agilent 7693, 7650, CombiPAL and 7697 headspace, with compatibility for third-party devices.
- Data System Software: MassHunter Acquisition and Analysis or Classic ChemStation, including target deconvolution, spectral matching, and libraries (NIST, Wiley, pesticide, toxicology, indoor air, etc.). Accurate mass measurements available via the Cerno MassWorks add-on.
Main Results and Discussion
The system delivers industry-leading signal-to-noise ratios and sub-femtogram detection limits (10 fg IDL for Extractor source). Mass axis stability is better than 0.10 u over 48 h. EI scan S/N ratios exceed 1,500:1 (Extractor source), while PCI and NCI modes achieve S/N of 125:1 and 600:1, respectively. With optional accurate mass software, mass accuracy reaches ±0.005 u and spectral accuracy exceeds 99%. The integrated instrument control and communication between GC and MSD enhance method development, autotuning and safety.
Benefits and Practical Applications
Key advantages include ultra-high sensitivity for trace analysis, versatile ionization modes for a broad compound range, rapid method development supported by software intelligence, and eco-friendly features that reduce energy consumption. The system is well suited for environmental monitoring, forensic toxicology, food contaminant screening, QA/QC workflows and research in semivolatile organics.
Future Trends and Applications
Advancements are expected in real-time data processing with machine learning, further miniaturization of GC/MS devices for field deployment, expanded accurate mass workflows, and deeper integration with laboratory automation. Emerging applications include untargeted metabolomics, comprehensive two-dimensional GC/MS and on-site environmental screening.
Conclusion
The Agilent 7890B/5977A GC/MSD system offers a robust, high-throughput solution with unmatched sensitivity and stability. Its combination of flexible ionization modes, advanced software and eco-efficient design positions it as a leading choice for demanding analytical laboratories.
References
Agilent Technologies Inc. Agilent 5977A Series GC/MSD System Data Sheet, Publication 5991-1838EN, June 3, 2014.
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