Bruker BRAVO HANDHELD RAMAN SPECTROMETER

Importance of Handheld Raman Spectrometry

Handheld Raman spectrometers play a critical role in rapid, non-destructive analysis of raw materials across pharmaceutical, forensic, art conservation and industrial quality control sectors. By delivering high-quality spectra in field or production environments, these instruments support timely decision-making, reduce the need for complex sample preparation and enhance compliance with regulatory standards.

Objectives and Overview

This application note presents the BRAVO handheld Raman spectrometer, designed to provide fast, reliable identification and verification of raw materials. Key objectives include:

• Ensuring high spectral quality under diverse conditions
• Mitigating fluorescence interference for broader applicability
• Facilitating intuitive workflows for non-specialist users
• Maintaining compliance with pharmaceutical regulations

Methodology and Instrumentation

The BRAVO system integrates advanced hardware and software elements:

• SSE™ (Sequentially Shifted Excitation) for patented fluorescence mitigation through controlled laser temperature shifts
• DuoLaser™ excitation at 785 nm and 852 nm for broad spectral coverage and enhanced sensitivity
• Laser Class 1 design eliminating additional safety requirements
• OPUS TOUCH GUI with guided workflows and IntelliTip™ for automatic tip recognition
• Interchangeable measurement tips for powders, tablets, vials, bottles and foils
• WiFi, Ethernet and SyncService for automated data transfer and audit-ready record keeping

Main Results and Discussion

Testing demonstrates that SSE™ extends the range of detectable materials by suppressing fluorescence from challenging samples. DuoLaser™ excitation ensures clear identification across a wide Raman shift range. The combination of robust hardware and user-friendly software yields rapid verification results, supported by libraries of over 20,000 spectra and the ability to create custom libraries.

Benefits and Practical Applications

The BRAVO system delivers:

• Fast, accurate raw material screening in production and research labs
• Reduced safety overhead with Class 1 laser operation
• Efficient workflow via guided on-screen procedures and accessory tips
• Regulatory compliance (21 CFR Part 11, USP, Ph. Eur.) with full audit trails and validation documentation
• Remote control capability comparable to benchtop instruments

Future Trends and Opportunities

Looking ahead, integration with cloud-based analytics and AI-driven spectral interpretation will further streamline decision-making. Expanding reference libraries through community-sourced data and enhancing miniaturization could open new applications in environmental monitoring, counterfeit detection and on-site clinical diagnostics.

Conclusion

The BRAVO handheld Raman spectrometer combines innovative fluorescence mitigation, dual-wavelength excitation and intuitive software to deliver high-performance material verification. Its versatile design and compliance features make it a valuable tool for industries requiring reliable, rapid spectroscopic analysis.