RM F MIX-1 - ASTASOL® - CH CE822P Calibration standard solution for chromatography in CERTAN® capillary bottle

Importance of the topic

The availability of reliable calibration standards for chlorinated phenols and related analytes is essential for accurate chromatographic analysis in environmental and industrial laboratories. High-quality reference materials ensure traceability, improve data comparability across laboratories, and support regulatory compliance in water quality monitoring, food safety, and chemical manufacturing quality control.

Objectives and Overview of the Study

This identification sheet describes ASTASOL®-CH CE822P, a certified calibration standard solution containing 23 phenolic compounds at 100 ± 1 µg/ml in 2-propanol. The main objective is to document the formulation, traceability, and quality control procedures for this reference material following ISO Guide 31 and ISO 17034:2017 guidelines.

Methodology and Preparation

• Gravimetric preparation: Each pure analyte is precisely weighed using an electronic microbalance (Mettler MT5) to account for purity deviations from 100%.
• Dissolution and dilution: Analytes are dissolved and quantitatively transferred into class A volumetric flasks. Dilution and weighing tolerances are controlled to remain within ± 0.5% overall uncertainty contributions.
• Quality control: The nominal composition is verified by comparison to an independent internal standard solution to confirm concentration accuracy.

Used Instrumentation

• Mettler MT5 electronic microbalance (readability 0.000001 g, automatic calibration)
• Class A calibrated volumetric flasks
• Amber glass CERTAN® bottles for storage and stability

Main Results and Discussion

The developed standard solution demonstrates an assigned concentration of 100 µg/ml for each of the 23 analytes at 20 °C with an expanded uncertainty of ± 1 µg/ml (k = 2). Stability testing indicates that, under storage at 5–10 °C in the dark, analyte concentrations remain within specification for at least two years. Rapid handling at ambient temperature minimizes exposure-induced degradation.

Benefits and Practical Applications

• Ensures precise calibration for gas or liquid chromatography methods targeting phenolic pollutants.
• Supports environmental monitoring laboratories and industrial QA/QC by providing traceable standards.
• Reduces analytical variability and enhances comparability of results across different laboratories and instruments.

Future Trends and Opportunities

The growing demand for multi-analyte reference materials highlights opportunities to expand certified panels to emerging contaminants and to develop aqueous and solvent-based mixes for direct injection in modern chromatography systems. Automation in preparation and expanded uncertainty characterization using Monte Carlo simulations can further refine accuracy.

Conclusion

ASTASOL®-CH CE822P offers a rigorously prepared and certified solution for phenolic compound analysis, combining gravimetric traceability, stringent quality control, and long-term stability. Its implementation in chromatographic workflows enhances data reliability and regulatory compliance.