STRam Raman spectrometer for analyses through non-transparent packaging

Importance of the Topic

Raman spectroscopy provides a rapid, non-destructive approach to identify and characterize materials through opaque containers, supporting quality control, supply chain security, and regulatory compliance in pharmaceutical, chemical and industrial sectors.

Objectives and Study Overview

This document details the standard scope of delivery and optional accessories for the STRam Raman spectrometer package, enabling users to configure the system for specific analytical workflows.

Methodology and Instrumentation

The STRam system integrates a 785 nm excitation source, fiber-optic probe for remote sampling and dedicated software for data acquisition and material identification.

• BWSpec general spectroscopy software for instrument control, data acquisition, real-time peak analysis and trending
• STRam probe: fiber-optic probe with 105 µm excitation and 300 µm collection fibers, adhesive sealed quartz window, accessories (focus adapter, surface regulator, calibration cap)
• Polystyrene reference material for performance validation
• Laser safety goggles and carrying case

Main Findings and Discussion

Although no quantitative results are reported, the comprehensive accessory suite supports versatile sampling modes, inline and immersion measurements, and seamless integration with chemometric and identification software libraries, ensuring accurate material verification across diverse applications.

Benefits and Practical Applications

The STRam package enables:

• Non-invasive, through-barrier analysis of sealed products
• Rapid material identification using user and third-party libraries
• Compliance with FDA 21 CFR Part 11 when using BWID Pharma Raman ID software
• Adaptation to laboratory, field, and industrial environments via modular probes and flow cells

Future Trends and Opportunities

Advancements may include higher-sensitivity detectors, expanded spectral libraries, AI-driven analysis, and miniaturized probes for real-time process monitoring and remote diagnostics in logistics and manufacturing.

Conclusion

The STRam Raman spectrometer system delivers a flexible, field-ready solution for non-destructive analysis through opaque packaging, combining robust hardware, dedicated software, and extensive accessory options to address regulatory and quality assurance needs.

Instrumentation used

The key components:

• STRam Raman spectrometer (785 nm excitation)
• BWSpec and BWID software suites
• Lab-grade fiber-optic probe with sealing window
• Polystyrene validation standard