Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor (Product specifications)

Importance of the Topic

The increasing demand for high-throughput and reproducible sample preparation in analytical chemistry has driven the adoption of automated extraction and concentration platforms.
Accelerated solvent extraction (ASE) addresses challenges in environmental monitoring, food safety, and industrial quality control by delivering efficient recovery of organic analytes while minimizing solvent use and operator intervention.

Study Objectives and Overview

This application note introduces the Thermo Scientific EXTREVA ASE system, a fully automated accelerated solvent extractor combined with an integrated concentrator.
The system is designed to streamline workflows from solid or semi-solid sample loading through extract concentration in chromatography vials, aiming to boost throughput, reduce costs, and enhance data quality in routine analytical laboratories.

Used Instrumentation

• Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor (extraction only or extraction + evaporation configurations)
• Stainless steel extraction cells (1–100 mL) compatible with ASE 150/350
• Savant SpeedVac Refrigerated Vapor Trap for solvent recovery
• Welch vacuum pump (required for evaporation feature)
• Integrated 2D barcode reader for sample tracking
• Chromeleon CDS software or local touch-screen controller

Methodology

The EXTREVA ASE employs a patented gas-assisted solvent delivery mechanism, mixing nitrogen and organic/aqueous solvents at temperatures up to 200 °C and pressures up to 200 psi.
Extraction can run in parallel (up to four channels) or sequentially, with programmable solvent flow rates and purge steps.
Extracts are collected in proprietary glass assemblies, then concentrated in situ via combined heating, vacuum and nitrogen blowdown to dryness or to a preset volume in GC/LC vials.

Main Results and Discussion

• Automated, walk-away operation from sample to vial for up to 16 samples per batch (including evaporation).
• Parallel extraction and concentration reduce hands-on time and streamline scheduling.
• New gas-assisted delivery lowers solvent consumption while maintaining high analyte recovery.
• Artificial-intelligence-driven end-point detection ensures consistent and reproducible concentration.
• Local or CDS-based control enables easy integration into GC, GC/MS, LC or LC/MS workflows.

Benefits and Practical Applications

• Significant labor savings through unattended extraction and concentration.
• Enhanced throughput supports environmental, food safety and industrial QA/QC laboratories.
• Lower solvent costs and reduced waste disposal requirements.
• Flexible extraction modes accommodate diverse sample matrices.
• Accurate sample tracking via barcode reduces data errors.

Future Trends and Applications

• Integration with laboratory robotics and IoT for fully connected workflows.
• Expansion of green solvent protocols to further reduce environmental impact.
• Application of machine-learning algorithms for real-time method optimization.
• Miniaturized extraction formats for trace analysis in clinical and forensic laboratories.

Conclusion

The Thermo Scientific EXTREVA ASE system offers a robust solution for modern analytical laboratories seeking to automate sample preparation, enhance throughput and improve reproducibility.
By combining accelerated solvent extraction with integrated concentration in one platform, the system reduces costs, saves labor and delivers high-quality data for a wide range of applications.