Metrohm NanoRam-1064 handheld Raman spectrometer
Brochures and specifications | 2021 | MetrohmInstrumentation
Reliable verification of raw materials is critical in pharmaceutical production to guarantee product safety and efficacy. Handheld Raman spectroscopy provides a non-destructive, rapid identification technique that supports regulatory compliance and accelerates materials release across the lab, warehouse, and field.
This document presents the NanoRam-1064, a state-of-the-art portable Raman instrument designed to simplify material identification workflows. Key objectives include minimizing fluorescence interference, enabling through-container analysis, and offering a user-friendly interface for non-technical operators.
The NanoRam-1064 leverages a 1064 nm laser excitation source to reduce fluorescence in colored or opaque samples. Analysis is conducted by collecting Raman spectra in the 176–2500 cm-1 range. Robust multivariate algorithms, based on representative spectra and p-value statistics, deliver reliable pass/fail verification and mixture analysis.
Testing demonstrates that the NanoRam-1064 delivers low-noise spectra with fast measurement times, effectively identifying materials that exhibit strong fluorescence on other systems. The device distinguishes between different cellulose types, polysorbates, and coatings such as Opadry. Onboard libraries and user-defined methods support rapid library transfer and method validation.
The adoption of handheld Raman analyzers is expected to grow within Pharma 4.0, enabling real-time process monitoring and supply chain screening. Advances in cloud-based libraries, AI-enhanced chemometrics, and integration with digital quality platforms will expand applications into food safety, environmental testing, and forensic analysis.
The NanoRam-1064 offers a robust, fluorescence-minimizing handheld Raman solution for accurate and efficient raw material verification. Its compliance with major pharmacopeial standards and ease of use make it an essential tool for modern analytical workflows.
RAMAN Spectroscopy
IndustriesManufacturerMetrohm
Summary
Importance of the Topic
Reliable verification of raw materials is critical in pharmaceutical production to guarantee product safety and efficacy. Handheld Raman spectroscopy provides a non-destructive, rapid identification technique that supports regulatory compliance and accelerates materials release across the lab, warehouse, and field.
Objectives and Overview
This document presents the NanoRam-1064, a state-of-the-art portable Raman instrument designed to simplify material identification workflows. Key objectives include minimizing fluorescence interference, enabling through-container analysis, and offering a user-friendly interface for non-technical operators.
Methodology
The NanoRam-1064 leverages a 1064 nm laser excitation source to reduce fluorescence in colored or opaque samples. Analysis is conducted by collecting Raman spectra in the 176–2500 cm-1 range. Robust multivariate algorithms, based on representative spectra and p-value statistics, deliver reliable pass/fail verification and mixture analysis.
Instrumentation Used
- 1064 nm laser with 420 ± 30 mW output power and thermoelectric cooling for stability
- Spectral range of 176–2500 cm-1, high-brightness touch screen display
- Sampling accessories: point & shoot adaptor, vial holder, immersion probe, bottle adaptor, right-angle adaptor, large spot adaptor
- Embedded NOS-1064 software for onsite operation and NID EX PC software for data management and LIMS integration
- Wireless (Wi-Fi) and USB connectivity, barcode scanner, rechargeable Li-ion battery (>4 h), IP65 protection
Main Results and Discussion
Testing demonstrates that the NanoRam-1064 delivers low-noise spectra with fast measurement times, effectively identifying materials that exhibit strong fluorescence on other systems. The device distinguishes between different cellulose types, polysorbates, and coatings such as Opadry. Onboard libraries and user-defined methods support rapid library transfer and method validation.
Benefits and Practical Applications
- Non-destructive, through-container measurements preserve sample integrity
- Intuitive touch-screen workflow and single-handed operation reduce training requirements
- Compliance with USP <858>, EP 2.2.48, JP 2.26, and Chinese Pharmacopeia guidelines
- Integration with cGMP workflows, IQ/OQ/PQ documentation, and audit-ready data handling
Future Trends and Potential Uses
The adoption of handheld Raman analyzers is expected to grow within Pharma 4.0, enabling real-time process monitoring and supply chain screening. Advances in cloud-based libraries, AI-enhanced chemometrics, and integration with digital quality platforms will expand applications into food safety, environmental testing, and forensic analysis.
Conclusion
The NanoRam-1064 offers a robust, fluorescence-minimizing handheld Raman solution for accurate and efficient raw material verification. Its compliance with major pharmacopeial standards and ease of use make it an essential tool for modern analytical workflows.
References
- United States Pharmacopeia, General Chapter <858> Raman Spectroscopy
- European Pharmacopoeia 2.2.48 Raman Spectroscopy
- Japanese Pharmacopoeia 2.26 Raman Spectroscopy
- People’s Republic of China Pharmacopeia Guidelines on Raman Spectroscopy
- B&W Tek, NanoRam-1064 Documentation, Doc-Rev: 280001290-D (2021)
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