Chromatography & Mass Spectrometry Product Reference Guide

Význam tématu

The integration of advanced chromatography techniques with mass spectrometry, software, and sample preparation expands the analytical capabilities across environmental, pharmaceutical, food safety, clinical and forensic applications. Combining Dionex’s leadership in ion and liquid chromatography with Thermo Scientific’s mass spectrometry and informatics portfolio delivers faster, more sensitive and reliable workflows for complex matrices.

Cíle a přehled studie / článku

This product reference guide aims to present a unified platform of separation and detection tools, covering UHPLC, HPLC, GC, IC, LC-MS, Orbitrap technologies, software solutions, sample preparation systems, and service offerings. Key objectives include demonstrating instrument performance, flexibility, and end-to-end workflows optimized for productivity and data integrity.

Použitá metodika a instrumentace

Modular and integrated systems span the following categories:

• UHPLC and HPLC platforms (UltiMate 3000 series, Accela, SpectraSYSTEM, EASY-nLC, Transcend LX) with flow rates from nanoliters/min to 10 mL/min, pressures up to 1250 bar, and compatibility with standard, RSLC, and nano formats.
• Ion Chromatography (IC and RFIC) systems (ICS-5000, ICS-2100, ICS-1600/1100/900) with reagent-free eluent generation (RFIC-EG/ER), electrolytic suppressors, and high-precision autosamplers.
• Gas Chromatography (TRACE GC, FOCUS GC) and GC-MS platforms (ISQ, ITQ series) plus ICP-MS (XSERIES 2) for volatile organics, pesticides, and elemental analysis.
• Hybrid LC-MS and MS/MS systems: triple quadrupoles (TSQ Quantum, Vantage), ion traps (LCQ Fleet, LTQ XL, Velos Pro), and high-resolution Orbitrap-based instruments (Exactive, Q Exactive, Orbitrap Velos Pro, Elite).
• Software for data acquisition, processing, and enterprise integration: Chromeleon CDS, Xcalibur, Atlas, LIMS solutions, and application-specific packages (Proteome Discoverer, SIEVE, MetWorks).
• Automated sample preparation: Accelerated Solvent Extraction (ASE), AutoTrace SPE, on-line SPE-LC, evaporators (Rocket) and cartridge-based cleanup (OnGuard, InGuard).
• Service and support options: installation, preventive maintenance, support plans, compliance certification, training, and multi-vendor management.

Hlavní výsledky a diskuse

The combined portfolio delivers:

• UHPLC performance at standard HPLC cost, enabling high-throughput separations with improved resolution, faster run times, and broad flow-rate flexibility.
• Reagent-free IC with on-demand eluent generation, minimizing manual operations and ensuring consistent, low-noise baselines.
• Mass spectrometry solutions offering unmatched sensitivity, dynamic range, and mass accuracy from entry-level triple-quadrupoles to ultra-high resolution Orbitrap platforms.
• Seamless software integration across chromatography and MS instruments, supporting 21 CFR Part 11 compliance and enterprise-wide data management.
• Automated sample prep workflows reducing solvent use, labor, and variability while increasing throughput and reproducibility.

Přínosy a praktické využití metody

The synergy of separation technologies and detection systems enables:

• Rapid method development and routine walk-up analyses for diverse matrices.
• High confidence in qualitative and quantitative results through lower detection limits and improved reproducibility.
• Reduced operational costs via automation of eluent preparation, sample cleanup, evaporation, and instrument maintenance.
• Scalable workflows from research to regulated QC environments with comprehensive support and training.

Budoucí trendy a možnosti využití

Emerging opportunities include:

• Increased automation and remote operation with digital workflows and AI-driven data analysis.
• Enhanced multi-omics integration using high-resolution MS and automated sample prep for proteomics, metabolomics, and lipidomics.
• Miniaturization and microfluidic separation technologies to further reduce sample and solvent consumption.
• Cloud-based informatics and expanded LIMS integration for global laboratories and decentralized testing.

Závěr

The Thermo Scientific and Dionex combined portfolio offers a comprehensive, flexible, and future-ready suite of instrumentation, software, and services. By integrating advanced chromatography, mass spectrometry, and informatics, laboratories can achieve higher throughput, greater confidence, and lower cost-of-ownership across a wide range of analytical applications.

Reference

• No specific literature references were cited in the source document.