Thermo Scientific Chromatography Columns and Consumables 2016-2017

Importance of the topic

Precision sampling and secure sample containment are essential in chromatographic analysis to ensure reproducible results, minimize contamination, and achieve low detection limits, particularly in trace analysis and high-throughput environments.

Objectives and overview

This document presents the Thermo Scientific Chromacol portfolio of glass vials, closures and crimping tools designed for chromatography. It provides an overview of product types, their material composition, features for autosampler compatibility and workflow efficiency.

Methodology and instrumentation

• Borosilicate glass formulations (standard and Gold grade) characterized by low expansion and high purity to minimize active sites and background contamination.
• Comprehensive testing for compatibility with a wide range of GC and HPLC autosamplers from leading manufacturers.
• Utilization of precision-machined PTFE and glass vial sleeves to adapt various vial formats to common tray dimensions.

Used instrumentation

Chromacol vials and closures are compatible with most GC and HPLC autosamplers, including instruments from Agilent, Beckman, CTC, Gilson, Knauer, Shimadzu, Spark Holland, Thermo Scientific, Varian, VWR/Merck and Waters.

Key results and discussion

• Wide range of vial sizes (0.1 mL to 40 mL) with residual volumes as low as 1 µL for micro and high-recovery applications.
• Gold grade glass demonstrates superior chemical resistance and minimal extractables.
• Closure options include crimp, snap and screw caps with various septa materials to suit temperature and chemical requirements.
• Electronic and manual crimping/decrimping tools enhance workflow reproducibility and ergonomics.

Benefits and practical applications

• Reduced sample loss and carry-over for trace and ultra-trace analyses.
• Secure, leak-resistant seals for pressurized headspace and high-temperature applications.
• Standardized vial dimensions and sleeves simplify method transfer across laboratories.
• Convenience kits and instrument-specific accessory kits accelerate sample preparation and reduce inventory complexity.

Future trends and applications

Advances in automation will drive demand for vials and closures optimized for robotic handling and remote operations. Innovations in sealing materials and integrated sensor technologies may enable real-time monitoring of sample integrity and headspace pressure.

Conclusion

The Chromacol range provides a comprehensive solution for chromatographic sample containment, combining material purity, dimensional precision and compatibility with diverse autosampler platforms, thereby enhancing analytical reliability and laboratory efficiency.