TurboVap LV and TurboVap II - Evaporation Rates at Specified Conditions

Significance of TurboVap Evaporation Technology

Controlled solvent evaporation is a fundamental step in sample preparation across analytical chemistry, environmental testing and pharmaceutical laboratories. Precise and reproducible concentration of analytes without thermal degradation or contamination is critical for downstream qualitative and quantitative analyses.

Study Objectives and Overview

This application note characterizes solvent evaporation rates using two generations of the TurboVap system (LV and II). It provides a comparative data set for common organic and aqueous solvents under defined water bath temperatures and inert gas flows, supporting method development and throughput optimization.

Methodology and Instrumentation

• Evaporation systems: New TurboVap LV and New TurboVap II
• Sample volumes: 10 mL in 16 × 100 mm tubes (LV), 180 mL in 200 mL tubes with 1 mL endpoint stem (II)
• Water bath temperatures: 35 °C to 70 °C (LV), 40 °C to 90 °C (II)
• Inert gas flow: 1.4 to 2.0 L/min (LV), 2.3 to 4.0 L/min (II)
• Replicates: n=8 for LV trials, n=3 for II trials

Main Results and Discussion

Evaporation times decrease with increasing temperature and gas flow. For TurboVap LV, acetonitrile evaporated in 44 min at 35 °C (1.6 L/min) and 13 min at 70 °C (1.6 L/min). Dichloromethane was quickest at 12 min (35 °C, 1.9 L/min). Water required up to 190 min at 50 °C (2.0 L/min). TurboVap II handled larger volumes, achieving acetone evaporation in 28 min (55 °C, 2.5 L/min) and dichloromethane in 37 min (40 °C, 2.8 L/min). The data illustrate how thermal energy and gas flow synergistically enhance solvent removal efficiency.

Practical Benefits and Applications

The TurboVap platforms deliver reproducible dry-down processes, minimize sample loss and thermal decomposition, and support high-throughput workflows. They are suitable for environmental residue analysis, pharmaceutical QC, food safety testing and preparative concentration tasks across diverse solvent chemistries.

Future Trends and Applications

• Automation integration for seamless sample preparation pipelines
• Adaptive gas mixtures to protect oxidation-sensitive analytes
• Inline sensors for real-time monitoring of solvent evaporation endpoints
• Microscale and high-density formats for minimal sample volumes
• Solvent recovery modules to support green chemistry objectives

Conclusion

The comparative evaluation of TurboVap LV and II demonstrates that precise control of bath temperature and inert gas flow yields rapid and consistent evaporation across a wide range of solvents and volumes. These findings enable laboratories to tailor evaporation protocols for maximum throughput and data integrity.