Agilent GC/MS columns and supplies application compendium

Importance of the Topic

GC MS plays a crucial role in trace level and complex matrix analysis across regulated and emerging fields. The compendium addresses demands for high throughput, low detection limits and robust workflows that support productivity and data accuracy in modern laboratories.

Objectives and Scope

This compendium presents application specific recommendations for GC MS columns supplies and optimized methods covering industries such as cannabis testing energy and chemicals environmental analysis food and agriculture forensic toxicology metabolomics and pharmaceutical impurity studies. It aims to guide users in selecting the right columns and consumables to meet analytical requirements.

Methodology and Instrumentation

Agilent evaluated a range of GC systems including Intuvo 9000 8890 and 7890B coupled to mass spectrometers such as single quadrupole triple quadrupole ion trap and accurate mass Q TOF. Key consumables include low bleed columns HP 5ms UI DB 5ms DB 35ms UI DB UI8270D and specialty sample preparation tools such as QuEChERS SPME headspace and Captiva EMR. Workflows were validated for parameters including linearity precision limits of detection and robustness.

Key Results and Discussion

• Cannabis testing methods achieved ppb level quantitation of cannabinoids pesticides mycotoxins and terpenes with robust inert flow paths and backflushing strategies.
• Energy and chemical applications delivered improved sulfur compound profiling and fuel marker analysis using multidimensional GC and ion mobility techniques.
• Environmental workflows covered targeted volatile semivolatile and non targeted screening of pollutants in water soil air and food achieving stringent regulatory criteria.
• Food safety studies demonstrated rapid multiclass pesticide and contaminant screening in complex matrices using miniaturized QuEChERS and advanced MS MS detection.
• Forensic toxicology protocols provided fast sensitive detection of drugs of abuse cannabinoids and designer compounds in biological samples with effective source cleaning.
• Metabolomics experiments delivered reproducible profiling of short chain fatty acids and untargeted biomarkers using high resolution Q TOF detection.
• Pharmaceutical impurity analyses identified extractable leachables and genotoxic impurities with accurate mass workflows and extended calibration ranges.

Benefits and Practical Applications

• Enhanced productivity with increased sample throughput and simplified workflows.
• Improved sensitivity and selectivity enabling trace level quantitation in challenging matrices.
• Reduced maintenance and extended column lifetime through inert flow paths and advanced liners.
• Compliance with global regulatory standards across multiple industries.
• Flexible method adoption supported by CrossLab service for instrument and workflow optimization.

Future Trends and Opportunities

Advances in multidimensional gas chromatography high resolution accurate mass spectrometry and artificial intelligence driven data analysis will expand non targeted screening capabilities. Continued development of automated sample preparation micro extraction and miniaturized workflows will further increase laboratory efficiency and broaden applications in emerging fields such as exposomics metabolomics and real time monitoring.

Conclusion

The Agilent GC MS columns and supplies compendium offers a comprehensive collection of validated methods and consumable recommendations that address critical analytical challenges. By leveraging optimized instrumentation and advanced workflows laboratories can achieve superior performance reliability and compliance across diverse applications.

Instrumentation

• GC systems Agilent Intuvo 9000 8890 7890B
• MS detectors single quadrupole 5975 5977 triple quadrupole 7000 7010 ion trap 220 and accurate mass 7250 Q TOF
• Columns HP 5ms UI DB 5ms DB 35ms UI DB UI8270D DB 1701 VF 624ms VF EUPAH Select PAH CP Sil
• Sample preparation SPME headspace QuEChERS Captiva EMR lipid solid phase extraction

References

Agilent application compendium GC MS columns and supplies October 2021