ASMS: Waters Users Meeting 2025
YOUR JOURNEY TO ASMS 2025 STARTS HERE
Join the global mass spectrometry community and industry leaders at the Waters ASMS Users Meeting 2025.
Connect with prominent scientific figures, showcasing cutting-edge science to solve problems that matter. Experts from across industry and academia will be discussing their latest groundbreaking research and the technology.
Together we can help accelerate the benefits of pioneering science.
- Gain knowledge of the latest technologies and software that enable researchers to push the boundaries of science
- Forge deeper connections through networking opportunities with industry experts and thought leaders
- Choose your path with a variety of breakout sessions that allow for closer engagement with topics that bring out your passion for science
- Be the first to see our latest innovations in action
- Share your science with Waters' application and technology experts to explore how we can advance your scientific endeavors together
This event is free to attend, and all lunch and refreshments will be provided, including a drinks reception to close out the day.
ASMS Connecting Science Hub
Still deciding? Check out our ASMS content hub to see all the presentations from 2024.
Keep an eye on your inbox and follow our social channels for more updates, including details of our breakfast seminars.
We look forward to welcoming you in Baltimore.
AGENDA
See our latest agenda* below. More details, including booking links for our breakfast seminars will be published soon. Keep an eye on your inbox and our social channels for updates.
*Agenda is subject to change
11:30 AM-12:30 PM | Registration and Welcome Lunch
Grab and go lunch & networking. Fuel yourself up for the sessions.
12:30 PM-12:45 PM | Welcome & What's New
Kicking off the afternoon with a recap of all our latest developments.
12:45 PM-1:15 PM | Technology Showcase
Innovations driving step-change in performance.
1:15 PM-1:45 PM | Plenary 1 | Guess How Many Samples - Uninterrupted Quan Across Applications
- Mark Roberts (Principal Consulting Product Manager, Waters Corporation)
- David Gordon (Principal Consulting Development Scientist, Waters Corporation)
1:45 PM-2:15 PM | Plenary 2 (More information coming soon)
2:15 PM-2:45 PM | Refreshment Break
2:45 PM-3:15 PM | Plenary 3 | Advancing Proteasome Structural Biology with Charge Detection Mass Spectrometry
The proteasome is a central component of protein degradation pathways across all domains of life. When bound to activators and substrates in various stoichiometries, these complexes can exceed 1 MDa in molecular weight, posing significant challenges for native mass spectrometry analysis using traditional platforms. This presentation will highlight data acquired using a prototype Electrostatic Linear Ion Trap (ELIT)-based Charge Detection Mass Spectrometry (CDMS) instrument, which provides new insights into the stoichiometry of heterogeneous proteasomal complexes. The talk will also emphasize the synergy between CDMS and electron cryomicroscopy in structural biology.
- Prof. Siavash Vahidi (Assistant Professor, Department of Molecular and Cellular Biology, University of Guelph)
3:15 PM-3:45 PM | Plenary 4 (More information coming soon)
3:45 PM-4:00 PM | Main session wrap up and transition to breakouts
4:00 PM-5:00 PM | Breakout Session 1: Advances in Omics & MS Imaging
Part 1: Multimodal Mapping of Tissue and Cellular Metabolism Using DESI-MRM
- Matt Smith (Postdoctoral Researcher, Karolinska Institute Sweden)
4:00 PM-5:00 PM | Breakout Session 2: Characterization of Novel Gene and Protein-based Therapeutics
Analysis of biopharmaceuticals is critical for the development, manufacture and release of safe and efficacious therapeutics. In this rapidly evolving field, Mass Spectrometry (MS) continues to develop as a pivotal analytical technique. This breakout session will delve into the latest advancements and applications of MS and Liquid Chromatography (LC)-MS in biologics analysis. Attendees will gain insights into case studies, from MS characterization and quantification of complex biomolecules to the impact of routine high-resolution LC-MS in drug development and quality control. Key topics will include customer and collaborator presentations on Charge Detection Mass Spec (CDMS), and robust, deployable LC-MS implementation for biotherapeutic development. Join us to explore how new technologies are shaping the future of biologics and enhancing our understanding of these vital medicines.
4:00 PM-5:00 PM | Breakout Session 3: Solving Real-World Problems with Quantitative Mass Spectrometry
Part 1: Environmental Occurrence and Bioaccumulation of PFAS in an Urbanized Estuary Associated with AFFF Sources
Per- and polyfluoroalkyl substances (PFAS) are chemicals of emerging global concern due to their adverse effects on human and environmental health. In New Hampshire’s Great Bay, they are of particular concern because of PFAS-containing aqueous film forming foams (AFFF) used for fire training at the former Pease Air Force Base along with other emerging sources, such as industry discharge and wastewater treatment plant effluent. In this study, ten sites around Great Bay were sampled to investigate PFAS concentrations across different abiotic and biotic media in the estuarine environment including water, sediments, and biota. We sampled ten commonly occurring low trophic species, finding that benthic feeders (snails and crabs) have more PFAS than filter feeders (mussels, oysters, and clams) both in compound abundance and concentration, with the most abundant compounds being the long chain carboxylic acids (C8-C14), PFOS, FOSA, and 7:3FTA. Sediments were also dominated by long chain carboxylic acids and PFOS, as well as MeFOSA and EtFOSA, while surface waters were very low overall. This indicates that even though environmental samples have different profiles and abundance, compounds still readily accumulate in biota. By understanding this abiotic-biotic relationship and uptake pathway, we can better elucidate the bioaccumulation and biomagnification in marine systems to benefit future food web modeling and provide data for public health and environmental agencies and stakeholders.
- Christine Gardiner (Laboratory Manager, Chem Lab, Department of Biological Sciences, Dartmouth College)
Part 2: Enhancing DMPK Assessment of PROTACs Using Advanced Mass Spectrometry Technologies
Proteolysis-targeting chimeras (PROTACs) exploit the ubiquitin–proteasome system for targeted protein degradation, necessitating comprehensive DMPK evaluation for efficient drug development. This presentation highlights the use of the Acquity Premier with Xevo TQ Absolute for high-sensitivity (20pg/mL LLOD) UHPLC-MS/MS quantification in biological matrices, Xevo MRT for high resolution, high sensitivity metabolite identification, and DESI XS with Xevo TQ Absolute for targeted imaging and tissue distribution analysis in an in vivo rat model. The study determined the key pharmacokinetic and metabolic pathways, with linker cleavage and conjugation as primary biotransformations. Urinary elimination was the predominant clearance route, while liver and kidney were the major distribution sites. This integrated analytical workflow offers a powerful approach for accelerating PROTACs in drug discovery.
- Andrew Leightner (Sr. Principal Market Development Manager, Waters Corporation)
5:00 PM-6:00 PM | Cocktail Reception
Where to find us
Renaissance Baltimore Harborplace
202 E Pratt St
Baltimore, MD 21202
