In the lab, generating high-quality data is only half the challenge. Processing, reporting and reviewing that data efficiently and in a controlled manner is where the battle for cost-effectiveness and regulatory compliance can be won and lost. That’s why labs have Standard Operating Procedures (SOP) that outline how data should be analysed, reported and reviewed to ensure consistency, productivity and conformity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Work_Smarter_Review_Faster_with_Chromeleon_CDS_cover_7f2444553e.jpg" alt="Thermo Fisher Scientific: Work Smarter, Review Faster with Chromeleon CDS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Work_Smarter_Review_Faster_with_Chromeleon_CDS_cover_7f2444553e.jpg 244w," sizes="100vw" width="1600" height="1025">Thermo Scientific <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon Chromatography Data System (CDS)</a> provides a series of tools to aid data processing and reporting while ensuring adherence to regulatory and data integrity guidelines. It also includes another powerful tool, called View Settings, that help streamline and control data review by providing an easy way to walk reviewers through the various aspects of the data that should be examined.<h4>A smarter way to work</h4>One of the View Settings key capabilities is to allow users to configure and save custom collections of panes in the Chromeleon Chromatography Studio. Multiple View Settings files can be created and added to a sequence, each providing different views of the data so that every analyst, reviewer, or supervisor can interact with the data in a way that suits their role which may include emphasizing chromatograms, displaying calibration graphs, highlighting result tables, or presenting system suitability information. This tailored approach reduces time spent navigating between windows or searching for key metrics, enhancing focus, reducing cognitive load and improving accuracy.<h4>Guiding the review process step by step</h4>Beyond user customization, one of the most practical applications of View Settings is mapping them directly to each step of the SOP-driven review process. For many analysts, daily review involves repeating the same checks in the same order. With View Settings, each stage—like retention time verification, blank injection review, QC checks, and calibration curve validation—can have its own dedicated layout and the reviewer simply clicks between them.Each layout displays only the data required for that step, removing distractions and reinforcing SOP adherence. Clicking a peak in one pane instantly highlights related results in others, helping analysts quickly spot issues or trends.Out-of-specification results can also be flagged, allowing analysts to focus their attention where it’s needed most. This targeted approach helps streamline decision-making and reduces review time without compromising quality.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=eVlYCOzFiSg">Thermo Scientific Chromeleon CDS view settings</a>See how Chromeleon CDS enables users to create custom view settings to guide data review and ease training requirements</blockquote><h4>Consistency across the lab</h4>Beyond individual productivity, View Settings support lab-wide consistency. They can be saved, shared, and embedded in eWorkflow™ templates to standardize review processes across teams and sites. When procedures change, updated layouts can be rolled out with minimal disruption.They also simplify onboarding. New users can get up to speed faster, with pre-configured layouts, reducing complexity and cutting training time.<h4>Real benefits, every day</h4>So, what do labs gain from using View Settings?<ul><li>Faster data review, with only the data you need at each step</li><li>Reduced training time, thanks to guided, intuitive layouts</li><li>Fewer errors, as users follow structured review paths</li><li>Improved consistency, especially across large teams or global sites</li><li>Flexible control, with tools to update and deploy views centrally</li><li>Regulatory compliance, with easily documented steps and audit trails</li></ul><h4>Final thoughts</h4>As labs handle more data and complexity, tools that simplify the user experience aren’t optional — they’re essential. Chromeleon View Settings make data review faster, smarter, and more consistent. They might not be the flashiest feature — but in a well-run lab, they could be one of the most valuable.<h5>Want to learn more about time-saving features within Chromeleon software?</h5>Take a look at our <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/eventRegistration/EventLobbyServlet?target=reg20.jsp&amp;eventid=5017954&amp;sessionid=1&amp;key=370D77F31338CF6F6F92F8321937735E&amp;groupId=6227300&amp;sourcepage=register">Chromeleon knowledge byte webinar series</a> or visit the <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/chromatography/chromatography-learning-center/chromeleon-cds-information.html">Chromeleon university</a> for more how-to-videos.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">Visit us on LinkedIn</a>: #Chromeleon #Software #LabProductivityZoe JulianZoe Julian is a Product Marketing Manager for Chromatography and Mass Spectrometry software at Thermo Fisher Scientific. With over 12 years' experience of working with chromatography and mass spectrometry techniques with a background in GC and GC-MS(/MS) organic environmental analysis, she has helped many laboratories and industries improve their workflows through a unique understanding of their challenges. Transitioning to a focus on Chromeleon CDS she has shown customers how software solutions can improve their productivity and support their day-to-day operations.</blockquote>

Work Smarter, Review Faster with Chromeleon CDS

<blockquote>For part 1, please visit: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/6407">How Hot is TOO Hot? - Part 1</a></blockquote>For gas chromatographers, dealing with high temperatures is normal. One of the most frequent questions we receive from customers is: What is the maximum temperature a GC column can reach? In this technical tip, we will take a step back and clarify it from the basics.All columns have a specific temperature range within which they are stable and functional for extended periods of time, depending on the stationary phase, the material of the capillary tubing used, and the film thickness. Usually, the temperature limits are printed on the box, the metal label on the cage of the column, or they are reported on the QC certificate. If you are not able to find them and you are not sure what the temperature limits of your column are, please reach out to your technical sales consultant.&nbsp;<blockquote>Please note: exceeding the temperature limits might lead to permanent damage to the column and loss of performance.</blockquote><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Zebron_GC_Column_Benefits_52246188ae.jpg" alt="Phenomenex: Zebron GC Column Benefits" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Zebron_GC_Column_Benefits_52246188ae.jpg 245w," sizes="100vw" width="1297" height="742">The maximum temperature is usually made up of two numbers (e.g. 340/360 °C). Sometimes, there may be a single value. The lower temperature is called the maximum isothermal temperature. This is the highest temperature that the column can be exposed to for an extended period. The higher temperature is called the maximum program temperature. The column can be left at this temperature for approximately 10 minutes. After the column is exposed to excessive temperatures, the degree of performance loss is dependent on the temperature, the duration of the exposure, the stationary phase, and the amount of oxygen in the carrier gas. Greater damage occurs with longer exposure times, larger temperature excesses, higher oxygen concentrations, and a lack of carrier gas flow.Within the maximum temperature limits, columns usually also have a minimum temperature limit (e.g - 60 °C). Below the minimum temperature, the stationary phase loses its chromatographic properties, broadening peaks. However, there is no permanent damage; peaks regain their shape when the column is heated back above the lower temperature limit. Cryocooling a column to focus a sample at the front of the column does not damage a column. Still, columns below their minimum temperatures may be more brittle, so they should be handled with care.<h5>Zebron™ Inferno GC Columns</h5>Zebron Inferno columns allow you to push your standard analysis up to 430 °C for increased lab productivity and improved performance – especially if you struggle with high boiling compounds, contaminants, or carry-overs.<ul><li>Download brochure <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/application::paper.paper/3abd1967-c2b9-4f6a-998c-f910910c1b8a.pdf">HERE</a></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Zebron_Inferno_GC_Columns_How_it_works_8a767f68a7.jpg" alt="Phenomenex: Zebron Inferno GC Columns - How it works" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Zebron_Inferno_GC_Columns_How_it_works_8a767f68a7.jpg 245w," sizes="100vw" width="978" height="564"><h5>Zebron ZB-1XT SimDist GC Columns</h5>Glass Infusion™ technology for higher efficiency and greater column-to-column reproducibility also ensures increased accuracy for high temperature simulated distillation at temperatures up to 450 °C.<ul><li>More information HERE</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Zebron_ZB_1_XT_Sim_Dist_GC_Columns_dd3e7f0c32.jpg" alt="Phenomenex: Zebron ZB-1XT SimDist GC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Zebron_ZB_1_XT_Sim_Dist_GC_Columns_dd3e7f0c32.jpg 146w," sizes="100vw" width="677" height="722">

How Hot is TOO Hot? - Part 2

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 17th November 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you applicaton notes by Agilent Technologies, EST Analytical and Shimadzu!<h3>1. Agilent Technologies: Accurate Identification and Quantification of Pesticide Residues in Ghee</h3>Analysis by QuEChERS with GC/MS/MS using the Agilent 8890 GC and Agilent 7010 GC/TQ<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_pesticide_ghee_gc_5994_8399en_agilent_1cbd787002.pdf">Full PDF for download</a></li></ul>India is one of the largest producers of milk, contributing about 23% of global milk production.1 The dairy processing sector includes a wide range of products, such as milk, butter, cheese, ghee, yogurt, flavored milk, lactose-free dairy products, and value-added products like ice creams and yogurts. Amongst these, ghee production is significant because of its popularity, low cost of production, and versatile use. According to the Food Safety and Standards Authority of India (FSSAI), ghee is mentioned as a "product obtained exclusively from milk, cream or butter by a process that almost completely removes water and non-fat solids; it has a specially developed flavor and physical structure".2 Milk‑producing animals can be exposed to pesticides through their diet, such as feed and fodder containing pesticide residues, or through the direct application of pesticides for controlling ectoparasites on their bodies, in animal sheds, and in milk processing areas. Due to their persistent and lipophilic nature, pesticides tend to accumulate in the fat-rich tissues of animals. The FSSAI has specified maximum residue levels (MRLs) for 55 pesticides, and a tolerance limit of 0.01&nbsp;mg/kg for the remaining pesticides for which an MRL has not been&nbsp;fixed.&nbsp;Ghee consists of 98.9% fat, irrespective of the animal source. Among the short- and medium-chain saturated fatty acids, all samples contain butyric (C4:0), caproic (C6:0), caprylic (C8:0), and capric acid (C10:0).3 Since its introduction, the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=QuEChERS">QuEChERS method</a> has been widely used for the analysis of pesticides in several matrices. Some modifications to the original QuEChERS method have been introduced to ensure efficient extraction of pH-dependent compounds, to minimize degradation of susceptible compounds (such as base- and acid-labile pesticides), and to expand the spectrum of matrices covered. Ghee matrix has a very high lipid load, making it a difficult commodity for analysis pesticide residues. The primary challenge lies in obtaining an extract that contains the target analytes while minimizing the amount of fat. Co-extracted lipids in the extracts can be removed, to a high degree, by a freezing-out step or a C18 cleanup.&nbsp;During sample extraction, the sample is often diluted. To obtain a quantification limit of 0.01 mg/kg, the instrument should be able to detect the residues at a lower concentration. This application note addresses these requirements by combining a sample preparation technique covering multiclass pesticides, target-specific multiple reaction monitoring (MRM) data acquisition, and efficient software to simplify quantitative analysis. The Agilent 7010 triple quadrupole GC/MS system enabled trace-level detection and confident quantitation of 150 pesticides in ghee.<h4>Experimental&nbsp;</h4><h5>Equipment&nbsp;</h5>An Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890+GC">8890 GC</a> coupled to a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7010+GC%2FTQ">7010 GC/TQ</a> system equipped with high efficiency source was used for the analysis. The GC system was equipped with a multimode inlet with air cooling and midcolumn backflush based on an Agilent purged Ultimate union controlled by a pneumatic switching device. The method parameters are displayed in Table 1.<h4>Conclusion</h4>The limits of quantitation (LOQs) for the target list of over 150 compounds ranged from 2.5 to 5 mg/kg for the ghee matrix. To minimize interferences from the ghee matrix, numerous multiple reaction monitoring (MRM) transitions were employed. This approach helped to accurately identify and quantify the target compounds despite the complex sample matrix. The samples were diluted five-fold to ensure that the analytes were within the required detection range of the instrument. This dilution also helped in reducing the matrix effects, leading to more reliable results. The average analyte recoveries were between 70 and 130%, indicating that the method has good accuracy and precision. This range of recoveries demonstrates the method’s robustness and suitability for routine analysis of these compounds.<h3>2. EST Analytical: Analysis of Coffee Flavors by Purge and Trap Sampling</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Purge_and_Trap_Analysis_of_Coffee_Flavors_by_Purge_and_Trap_Sampling_ca25beef60.pdf">Full PDF for download</a></li></ul>Most of us who drink coffee know our preferences. We know which blend we like, what strength and definitely what we like in our coffee. However, most of us do not think about the flavors that go into our coffee that help us define our preferences. Coffee manufacturers, on the other hand are working diligently to create a new blend or a more satisfying flavor that would make us want to choose their coffee over another maker.&nbsp;This study will look at four different blends of coffee and some of the compounds that contribute to the flavor of the blend. Using purge and trap sampling, the flavor compounds were purged out of the coffee and trapped onto an adsorbent trap. The analytes were then transferred to a Gas Chromatograph/Mass Spectrometer (GC/MS) for analysis. The study focused on six flavor compounds. The spicy smoky aroma of 2-methylfuran, the spicy caramel, almond odor of 5-methylfurfural, the buttery scent provided by the addition of 2,3-butanedione and 2,3- pentanedione and the impact of the two and three methyl butanals giving the dark chocolate malty flavor to the coffee.<h4>Experimental:&nbsp;</h4>The EST Analytical <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2160">Encon Evolution Purge and Trap Concentrator</a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2159">Centurion WS Autosampler </a>were interfaced to a GC/MS. The Centurion WS was run in the soil mode and the purge and trap concentrator was configured with a Vocarb 3000 (K) analytical trap. The column selected for this study was an Rtx-1 60m x 0.25mm x 1µm. Listed in Tables 1 and 2 are the experimental parameters used for this study.<h4>Conclusion:&nbsp;</h4>The lightest roast had the most buttery and dark chocolate/malty flavors while the darkest roast had more of the smoky flavor. Surprisingly, the darkest roast and the medium roast had similar proportions of the flavor compounds with the exception of the smoky flavor. While the light roast had large amounts of the flavors tested for, the chromatography of the light roast was much simpler than that of the darker roasts. Overall, the Encon Evolution Purge and Trap Concentrator in conjunction with the Centurion WS Autosampler proved to be an excellent system for sampling coffee. The results were reproducible and provided a lot of information on the flavors of the respective coffees.<h3>3. Shimadzu: Analysis of Ethanol in E10 Gasoline Using Polyarc Microreactor for GC</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01033_en_d4ee66bd4f.pdf">Full PDF for download</a></li></ul>The flame ionization detector (FID) can detect almost all organic compounds, and the sensitivity of the obtained chromatograms displays a correlation with concentration and number of carbon atoms in the compound. However, as a weakness of FID, its sensitivity decreases when an organic compound contains oxygen atoms, asin the case of alcohols.&nbsp;The Polyarc microreactor improvessensitivity for alcohols and other compounds containing oxygen atoms (hereinafter, oxygenated compounds), allowing calibration using a single compound. Research and use of biofuels has accelerated in recent years, and more sensitive quantitative analysis of oxygenated compounds in multiple compoundsis now required.&nbsp;This Application News introduces an example of an analysis of a sample simulating E10 gasoline, in which 10 % ethanol by volume concentration was added to gasoline, demonstrating that enhanced sensitivity for oxygenated compounds can be achieved by adding Polyarc to the instrument configuration. The accuracy of the quantitative analysis was also verified using a general standard sample (alkane).<h4>Polyarc Microreactor</h4>Polyarc is a post-column type microreactor that is introduced between the column and the detector (FID). The organic compounds separated and eluted by the column are decomposed to methane by the Polyarc reactor in a two-stage oxidationreduction reaction (Fig. 1). Since the decomposed methane is detected by the FID, the uniform sensitivity for the carbon number can be obtained, regardless of the type of functional groups in a sample.<h4>Effective Carbon Number</h4>As mentioned above, the sensitivity of the FID detector varies depending on the types of functional groups in organic compounds. The detection sensitivity by the FID can be estimated based on the concept of the effective carbon number (ECN), which is an index showing how many carbon atoms in a compound function effectively. Depending on the type of functional groups contained in a compound, the carbon ratio in the molecule changes, and this causes changesin the sensitivity ofthe FID. For example, both ethane (C2H6) and ethanol (C2H5OH) contain the same number of carbon atoms of 2, but the sensitivity of the FID for ethanol is only 75 % of itssensitivity for ethane because the primary hydroxyl group (-OH) behaves as -0.5 carbon atoms in terms of its contribution to the ECN. This meansthe ECNof ethanol is 1.5. Table 1 shows several examples of other functional groups with ECNslowerthan the number of carbon atoms.<h4>Analysis Conditions</h4>In this Application News, sensitivity for ethanol when the Polyarc was added and when using only the FID was compared using an E10 sample, in which 10 v/v% ethanol was added to gasoline, simulating a biofuel which has attracted attention in recent years, and quantitativity for ethanol was confirmed. In the quantitative analysis, it was also carried out by the external standard method using a hydrocarbon (dodecane; C12) with a concentration of 1 w/v% as a standard sample. The analytical instrument was a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GC-2030">GC-2030</a> (SPL/FID) model gas chromatograph with the Polyarc added (Fig. 2). Table 2 shows the analysis conditions.<h4>Conclusion</h4>E10 gasoline was analyzed using an FID detector and an added Polyarc microreactor, confirming that oxygenated compounds can be analyzed with high sensitivity. This study also confirmed that a uniform reaction of organic compounds can be obtained in the FID, and peak broadening can be suppressed by standardizing the response of sensitivity. Table 6 introduces several of the advantages that are possible by adding the Polyarc microreactor. The Polyarc converts all organic compounds to methane having the same number of carbon atoms (mol), enabling highsensitivity detection for compounds with low detection sensitivity by FID alone. In addition, since sensitivity is standardized, quantitation is possible using only one arbitrary calibration curve, regardless of the type of analysis compound. As a result, it is now possible to analyze compounds that were difficult to analyze by FID until now.

News from LabRulezGCMS Library - Week 47, 2025

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