Wiley released a KnowItAll version with many new powerful electron ionization gas chromatography-mass spectrometry (EI GC-MS) capabilities. I have developed FREE training videos and associated handouts covering basic and advanced MS topics that will be helpful to the new user.
Also, a <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Published_Know_It_Al_Start_QRG_2_7114366b93/Published-KnowItAl-Start-QRG-(2).pdf">Quick Reference Guide</a>. is available.
KnowItAll is a vendor neutral data processing solution for spectral analyses which will be very valuable in unknown identifications.
It processes IR, Raman, MS, NMR, and UV data employing a large number of file formats (&gt;170) and a total of 2.5 million reference spectra.
<ul>
<li>~264K IR</li>
<li>~25K Raman</li>
<li>~1.25M EI mass spec</li>
<li>~894K NMR</li>
<li>~30K UV</li>
</ul>
<h3>Highlights:</h3>
<ul>
<li>Deconvolution/very fast library searching of accurate/nominal mass GC-MS data</li>
<li>Easy manual processing of nominal and accurate mass GC-MS data</li>
<li>Fast EI searches of &gt;1.2 million spectra in &lt;0.5 seconds</li>
<li>Amazing adaptive search for unknown ID by extending usefulness of all libraries</li>
<li>Transfer structures and spectra between NIST search and KnowItAll</li>
<li>Easy structure drawing and structure searches</li>
<li>Conversion of NIST user libraries to Wiley format</li>
<li>Easy creation of libraries using links to MS interpreter and PubChem</li>
</ul>
<h2>In the eleventh part we will look at:</h2>
Detailed Handouts including tables of content are available in the <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/making_user_library_efcf492308/making-user-library.pdf">LabRulezGCMS library</a>.
<ul>
<li>Skills Needed from Previous Videos and Handouts</li>
<li>Another Useful Reference on Databases</li>
<li>File Used for Demonstration</li>
<li>Process for Creating User Library (Database)</li>
</ul>
<h3>Future parts will focus on:</h3>
<ul>
<li>Part 1. <a href="https://gcms.labrulez.com/article/2974">KnowIt All Introduction</a></li>
<li>Part 2. <a href="https://gcms.labrulez.com/article/3059">ProcessIt for Manual Processing of EI GC-MS Data</a></li>
<li>Part 3. <a href="https://gcms.labrulez.com/article/3189">SearchIt/MineIt: Similarity Library Search</a></li>
<li>Part 4. <a href="https://gcms.labrulez.com/article/3269">SearchIt/MineIt; Novel New Adaptive Library Search</a></li>
<li>Part 5. <a href="https://gcms.labrulez.com/article/3288">SearchIt/MineIt: Unresolved Peak Analyses and Library Search</a></li>
<li>Part 6. <a href="https://gcms.labrulez.com/article/3302">MS Expert: Deconvolution of Mixtures with Library Search</a></li>
<li>Part 7. <a href="https://gcms.labrulez.com/article/3304">Interchange of Spectra Between KnowItAll and NIST Search</a></li>
<li>Part 8. <a href="https://gcms.labrulez.com/article/3306">Tips for Drawing Structures and Structure Searches in ChemWindow</a></li>
<li>Part 9. <a href="https://gcms.labrulez.com/article/3357">Structure Interchange Between KnowItAll and NIST plus MS Interpreter</a></li>
<li>Part 10. <a href="https://gcms.labrulez.com/article/3359">Converting NIST Libraries to Wiley Format</a></li>
<li>Part 12. Real World Example with IR and MS Combined searches</li>
</ul>

Wiley KnowItAll Mass Spec Training - Part 11. Making a User Library Using NIST MS Interpreter and PubChem

Wiley released a KnowItAll version with many new powerful electron ionization gas chromatography-mass spectrometry (EI GC-MS) capabilities. I have developed FREE training videos and associated handouts covering basic and advanced MS topics that will be helpful to the new user.
Also, a <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Published_Know_It_Al_Start_QRG_2_7114366b93/Published-KnowItAl-Start-QRG-(2).pdf">Quick Reference Guide</a>. is available.
KnowItAll is a vendor neutral data processing solution for spectral analyses which will be very valuable in unknown identifications.
It processes IR, Raman, MS, NMR, and UV data employing a large number of file formats (&gt;170) and a total of 2.5 million reference spectra.
<ul>
<li>~264K IR</li>
<li>~25K Raman</li>
<li>~1.25M EI mass spec</li>
<li>~894K NMR</li>
<li>~30K UV</li>
</ul>
<h3>Highlights:</h3>
<ul>
<li>Deconvolution/very fast library searching of accurate/nominal mass GC-MS data</li>
<li>Easy manual processing of nominal and accurate mass GC-MS data</li>
<li>Fast EI searches of &gt;1.2 million spectra in &lt;0.5 seconds</li>
<li>Amazing adaptive search for unknown ID by extending usefulness of all libraries</li>
<li>Transfer structures and spectra between NIST search and KnowItAll</li>
<li>Easy structure drawing and structure searches</li>
<li>Conversion of NIST user libraries to Wiley format</li>
<li>Easy creation of libraries using links to MS interpreter and PubChem</li>
</ul>
<h2>In the eleventh part we will look at:</h2>
Detailed Handouts including tables of content are available in the <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/white_powder_talk_full_with_long_page_e591038cc5/white_powder_talk_full_with_long_page.pdf">LabRulezGCMS library</a>.
<ul>
<li>KnowItAll Attributes</li>
<li>Standard Identity MS Search Fails</li>
<li>KnowItAll Adaptive Search (Patented)</li>
<li>KnowItAll Adaptive Search Yields Very Useful Results</li>
<li>Shifted Reference Versus Unknown for Hit Quality Index Calculations</li>
<li>Top 3 Hits in Adaptive EI Mass Spec Search - Unknown White Powder</li>
<li>IR Analysis of Solder Using KnowItAll</li>
<li>Results of IR Search Using “Mixture 2” Option</li>
<li>Comparing IR Spectra of Unknown to Components 1 and 2 in Mixture Result</li>
<li>Conclusions</li>
</ul>
<h3>Previous parts were focused on:</h3>
<ul>
<li>Part 1. <a href="https://gcms.labrulez.com/article/2974">KnowIt All Introduction</a></li>
<li>Part 2. <a href="https://gcms.labrulez.com/article/3059">ProcessIt for Manual Processing of EI GC-MS Data</a></li>
<li>Part 3. <a href="https://gcms.labrulez.com/article/3189">SearchIt/MineIt: Similarity Library Search</a></li>
<li>Part 4. <a href="https://gcms.labrulez.com/article/3269">SearchIt/MineIt; Novel New Adaptive Library Search</a></li>
<li>Part 5. <a href="https://gcms.labrulez.com/article/3288">SearchIt/MineIt: Unresolved Peak Analyses and Library Search</a></li>
<li>Part 6. <a href="https://gcms.labrulez.com/article/3302">MS Expert: Deconvolution of Mixtures with Library Search</a></li>
<li>Part 7. <a href="https://gcms.labrulez.com/article/3304">Interchange of Spectra Between KnowItAll and NIST Search</a></li>
<li>Part 8. <a href="https://gcms.labrulez.com/article/3306">Tips for Drawing Structures and Structure Searches in ChemWindow</a></li>
<li>Part 9. <a href="https://gcms.labrulez.com/article/3357">Structure Interchange Between KnowItAll and NIST plus MS Interpreter</a></li>
<li>Part 10. <a href="https://gcms.labrulez.com/article/3359">Converting NIST Libraries to Wiley Format</a></li>
<li>Part 11. <a href="https://gcms.labrulez.com/article/3362">Making a User Library Using NIST MS Interpreter and PubChem</a></li>
</ul>

Wiley KnowItAll Mass Spec Training - Part 12. Real World Example with IR and MS Combined searches

In the week from December 18, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.
<blockquote>
<h4><a href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>
</blockquote>
<blockquote>
👉 Search and filter in more than 3 000 GC, LC and MS webinars.
</blockquote>
<h5>1. Agilent Technologies: The Digital Lab Connection</h5>
<ul>
<li>We, 20.12.2023, 11:00 (CET)</li>
<li><a href="https://gcms.labrulez.com/webinar/2882">Registration</a></li>
</ul>
Using IoT sensor technologies, AI modeling, and advanced analytics, your digital lab can safely capture data.
<h5>2. Gulf Bio Analytical Group: Improving GC×GC workflows for petrochemical analyses</h5>
<ul>
<li>We, 20.12.2023, 13:00 (CET)</li>
<li><a href="https://gcms.labrulez.com/webinar/3332">Registration</a></li>
</ul>
Learn the basics of GC×GC and what it offers over and above standard GC.

Webinars LabRulezGCMS Week 51/2023

In the January 2024, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.
<blockquote>
<h4><a href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>
</blockquote>
<blockquote>
👉 Search and filter in more than 3 000 GC, LC and MS webinars.
</blockquote>
<h5>1. Agilent Technologies: Rapid food and feed analysis through VOC analysis using SICRIT technology</h5>
<ul>
<li>We, 17.1.2024, 20:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3129">Registration</a></li>
</ul>
Recent work undertaking using SICRIT technology for both targeted and untargeted food and feed monitoring tasks.
<h5>2. DataApex: Clarity Tips &amp; Tricks Webinar</h5>
<ul>
<li>Th, 18.1.2024, 09:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3350">Registration</a></li>
</ul>
Learn incredible tricks and tips for maximizing your experience with Clarity Chromatography Software. Dive into advanced functionalities and discover how to elevate your workflows.
<h5>3. Waters Corporation: Empower Tips: Ask Me Anything About Data Flow and Data Process Mapping with Data Governance in Mind</h5>
<ul>
<li>Th, 18.1.2024, 16:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3235">Registration</a></li>
</ul>
Please join us for a lively discussion as we explore data flow and data process mapping with data governance in mind.
<h5>4. Shimadzu Corporation: For the Love of Food! Solutions for Contaminants From PFAS to Heavy Metals</h5>
<ul>
<li>Th, 25.1.2024, 07:30 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3357">Registration</a></li>
</ul>
Gear up for an exciting session leading to the heart of food safety analysis, focusing on 3 crucial aspects: organic contaminants identification, elemental analysis, and the pressing issue of PFAS.
<h5>5. Agilent Technologies: Session 4 – OpenLab CDS for MS Data</h5>
<ul>
<li>Tu, 30.1.2024, 18:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3220">Registration</a></li>
</ul>
Learn how to set up calculations in the Custom Calculator and Intelligent Reporter.
<h5>6. Agilent Technologies: Unlocking Pesticide Analysis Excellence: Proven Tactics for Optimal Results with Helium and Hydrogen</h5>
<ul>
<li>We, 31.1.2024, 17:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3010">Registration</a></li>
</ul>
Expert strategies for enhancing analytical performance in the analysis of pesticides in challenging food matrices with the 7000E GC/TQ and the 7010C GC/TQ.

Webinars LabRulezGCMS January 2024

Robert Hanus, leader of the <a href="https://hanus.group.uochb.cz/cs">Chemistry of Social Insects research group</a> at IOCB Prague, has been enrolled in the Hop On Facility program of the European Commission. This facility helps researchers from countries that entered the EU in later rounds of enlargement to join ongoing projects being conducted by colleagues in original member states. Robert is thus joining the European project SMELLODI, which is being pursued by a consortium of seven research centers and technology institutes from Germany, Israel, and Finland. The goal is to establish the foundations for the digitization of human body odors. In the future, the technology could enhance diagnostic and health monitoring capabilities. 
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_UOCHB_se_nove_podili_na_evropskem_projektu_digitalizace_lidske_telesne_vune_1e4b23ff57/UOCHB-Tomas-Bellon-UOCHB-se-nove-podili-na-evropskem-projektu-digitalizace-lidske-telesne-vune.jpg" alt="IOCB Prague/Tomáš Belloň: IOCB Prague newly participates in the European project of digitization of human body odour"/>
<a href="https://smellodi.eu/">SMELLODI</a>, a three-year EIC Pathfinder Open funded project with a grant of nearly three million euros, is initiating a new era of digitizing human olfaction. The project focuses on intelligent electronic recognition and transmission of body odors.
Robert explains: “Our current understanding doesn’t yet allow us to upload odors and, say, send them halfway around the world and then have them regenerated there the way we can with images and sounds.”
In addition to essential cutting-edge technology, IOCB Prague is bringing to the SMELLODI project a wealth of knowledge in the field of chemical analysis of volatile substances. Robert’s research group uses a modern two-dimensional gas chromatograph, which is not only extremely sensitive and capable of separating individual components of odors but is also equipped with an olfactometric port. Researchers can thus send selected components of an odor directly into a person’s nose and track their subjective reactions to them.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Projekt_SMELLODI_Chytry_elektronicky_cich_0f354ddff1/UOCHB-Projekt-SMELLODI-Chytry-elektronicky-cich.jpg" alt="IOCB Prague/SMELLODI project: Smart electronic sense of smell"/>
Robert says he became involved in the project by coincidence. His group primarily uses gas chromatography to study the chemical communication of insects and for recording chemical profiles on the bodies of insects. Nonetheless, in a joint project with colleagues at the Faculty of Science, Charles University, they discovered that the method can also be used to differentiate and quite accurately describe the body odors of individual people. The determination on the part of Robert and his colleagues to pursue activities not directly relating to their original research aims soon put them in the company of leading European experts in the field.
The enthusiasm of Robert’s team is shared by the director of IOCB Prague, Prof. Jan Konvalinka: “It’s extraordinarily interesting to find out that chemical substances decide who smells good or bad to us and what things evoke either positive or negative emotions in us. It’s fascinating to watch how Robert’s work on insect pheromones can be applied to human body odors.”
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Robert_Hanus_Ph_D_vedouci_vedecke_skupiny_Chemie_spolecenskeho_hmyzu_v_UOCHB_ea61dbd077/UOCHB-Tomas-Bellon-Robert-HanusPh.D.-vedouci-vedecke-skupiny-Chemie-spolecenskeho-hmyzu-v-UOCHB.jpg" alt="IOCB Prague/Tomáš Belloň: Robert Hanus,Ph.D. - leader of the Chemistry of Social Insects research group at IOCB Prague"/>
Robert adds: “Thanks to the Hop On program, even at more than forty years of age I can begin exploring a completely different area of research. Grant agencies would hardly provide separate funding for an individual with no professional history in a given field. In the Hop On Facility project, however, a key criterion is the significance of a new partner for the entire consortium. Clearly, it makes sense to constantly strive for something new.”
Part of the Horizon Europe framework program, the Hop On Facility offers applicants from thirteen EU countries, among them Czechia, an opportunity to join ongoing grant projects. A list of suitable projects is posted on the Funding &amp; Tender Opportunities Portal (FTOP), and the European Commission updates it each week with new offers. Proposals for a new partner in an ongoing research endeavor are assessed by a group of independent experts, and the addition of a new partner must facilitate achievement of the original goals without diverting the project.
<blockquote>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Specializovane_GC_MS_systemy_GC_GC_TOFMS_LECO_Pegasus_4_D_2_e7cd6d85f9/UOCHB-Specializovane-GC-MS-systemy-GCGC-TOFMS-LECO-Pegasus-4D-2.jpg" alt="IOCB Prague/Specialized GC-MS systems: GC×GC-TOFMS LECO Pegasus 4D"/>
</blockquote>
<blockquote>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Specializovane_GC_MS_systemy_GC_GC_TOFMS_LECO_Pegasus_4_D_631bd6ec28/UOCHB-Specializovane-GC-MS-systemy-GCGC-TOFMS-LECO-Pegasus-4D.jpg" alt="IOCB Prague/Specialized GC-MS systems: GC×GC-TOFMS LECO Pegasus 4D"/>
</blockquote>

IOCB Prague to contribute to a European project on the digitization of human body odors

In the next 14 days, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.
<blockquote>
<h4><a href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>
</blockquote>
<blockquote>
👉 Search and filter in more than 3 000 GC, LC, MS and Spectroscopy webinars.
</blockquote>
<h5>1. Wasson-ECE Instrumentation: The Next Frontier for Process GC Webinar</h5>
<ul>
<li>Fr, 12.1.2024, 15:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3379">Registration</a></li>
</ul>
Prezentace se bude týkat nejnovější produktové řady společnosti Wasson-ECE, procesních plynových chromatografů Eclipse, nejvýkonnějších procesních analyzátorů dostupných pro uhlovodíkový průmysl.
<h5>2. Agilent Technologies: Rapid food and feed analysis through VOC analysis using SICRIT technology</h5>
<ul>
<li>We, 17.1.2024, 20:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3129">Registration</a></li>
</ul>
Recent work undertaking using SICRIT technology for both targeted and untargeted food and feed monitoring tasks.
<h5>3. DataApex: Clarity Tips &amp; Tricks Webinar</h5>
<ul>
<li>Th, 18.1.2024, 09:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3350">Registration</a></li>
</ul>
Learn incredible tricks and tips for maximizing your experience with Clarity Chromatography Software. Dive into advanced functionalities and discover how to elevate your workflows.
<h5>4. Waters Corporation: Informatics series #13 Sample Weights in Empower</h5>
<ul>
<li>Th, 18.1.2024, 11:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3392">Registration</a></li>
</ul>
V této části si ukážeme různé možnosti přenosu hmotnosti vzorku do aplikace Empower.
<h5>5. Waters Corporation: Empower Tips: Ask Me Anything About Data Flow and Data Process Mapping with Data Governance in Mind</h5>
<ul>
<li>Th, 18.1.2024, 16:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3235">Registration</a></li>
</ul>
Please join us for a lively discussion as we explore data flow and data process mapping with data governance in mind.

Webinars LabRulezGCMS Week 2-3/2024

LabRulez is the name of a group of web portals that uniquely link and present information in the field of analytical chemistry, separation techniques, spectroscopy or chemistry, research and technologies.
The portal currently consists of three main parts and its scope is expanding.
<ul>
<li><a href="https://lcms.labrulez.com/">LabRulezLCMS (ENG)</a> focused on the liquid phase.
</li>
<li>The <a href="https://lcms.cz/">LabRulezLCMS (CZ)</a>
</li>
<li><a href="https://gcms.labrulez.com/">LabRulezGCMS (ENG)</a> focused on the gas and solid phases.
</li>
<li><a href="https://gcms.cz/">LabRulezGCMS (CZ)</a>
</li>
<li>NEW: <a href="https://icpms.labrulez.com/">LabRulezICPMS (ENG)</a> focused on atomic and molecular spectroscopy.
</li>
<li>NEW: <a href="https://icpms.cz/">LabRulezICPMS (CZ)</a>
</li>
</ul>
For the LabRulez portals, year 2023 was a very successful year, especially in terms of traffic growth, but also in terms of content and partners. In terms of statistics, we achieved almost 100% growth compared to 2022 in all areas:
<ul>
<li>more than 20,740,000 impressions on Google alone.</li>
<li>more than 918,000 opened applications in our unique library</li>
<li>more than 654,000 page views</li>
<li>more than (3)146,000 unique visitors</li>
</ul>
As a media partner, we have attended and shared information from <a href="https://lcms.cz/articles?tags=9">14 Czech/Slovak conferences or seminars</a> and this January we are also proud to be a partner of the international conference on <a href="https://gcms.labrulez.com/companies/218">multi-dimensional chromatography (GCxGC, 2D-LC) MDCW</a> which will take place in Los Angeles (USA) this week.
<blockquote>
Become part of our portals and community and raise awareness of your work, products or services. Build your brand and attract new customers, partners and projects in a targeted community of analytical chemists or in internet search engines. Anyone can take advantage of the LabRulez portals:
</blockquote>
<blockquote>
<ul>
<li>Commercial business company (products and services)</li>
<li>Commercial laboratory (services and expertise)</li>
<li>State institutions and laboratories (public information and HR)</li>
<li>Universities and research institutions (project outputs, publications, popularization)</li>
<li>Groups or individuals (commercial or academic)</li>
</ul>
</blockquote>
<blockquote>
Contact us at info@labrulez.com or by phone and we will be happy to discuss all the details with you.
</blockquote>
On the portals you can follow webinars, scientific events and exhibitions, professional and popularization news or job offers. Search and filter through hundreds of products in one place. Plus, view or download documents from an extensive and unique library that includes apps, scientific and technical articles, posters, manuals, or presentations. LabRulez is thus a comprehensive source of knowledge and information for analytical chemists and anyone interested in the field.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_Banner_2023_24_ENG_f192298172/LabRulez-Banner-2023-24-ENG.jpg" alt="LabRulez: LabRulez results in 2023"/>
<h3>Finally, we asked a general question to the AI BING , an artificial intelligence that has access to the online environment, and what did we learn?</h3>
<h5>LabRulez query for AI BING</h5>
Why would you recommend that analytical chemists regularly visit the LabRulez portals?
<h5>Answer from AI BING</h5>
I would recommend that analytical chemists regularly visit LabRulez portals because:
<ul>
<li>LabRulez portals provide updated and high quality information on analytical chemistry, chromatography, spectroscopy and other related techniques.
</li>
<li>On LabRulez portals you can expand your knowledge and skills¨ through webinars, events, articles and products from various companies and experts.
</li>
<li>On LabRulez portals, you have unique access to an extensive and growing database that includes applications, scientific and technical articles, posters, manuals and presentations.
</li>
<li>On the LabRulez portals you can find or offer jobs, sell or buy analytical instrumentation, services or opportunities to access the growing requirements of your laboratories.
</li>
</ul>
<h5>LabRulez Summary</h5>
What more to say? Perhaps it&#39;s that we&#39;re really preparing and improving a lot for you in 2024... Maybe at the end of this year you&#39;ll be able to talk to AI about your requirements and problems in our globally unique academic section.
Keep your fingers crossed, support us, become part of us and build with us a purely Czech project with global ambitions.

LabRulez portals in 2023 (How was it?)

In the next 14 days, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.
<blockquote>
<h4><a href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>
</blockquote>
<blockquote>
👉 Search and filter in more than 3 000 GC, LC, MS and Spectroscopy webinars.
</blockquote>
<h5>1. Agilent Technologies: Rapid food and feed analysis through VOC analysis using SICRIT technology</h5>
<ul>
<li>We, 17.1.2024, 20:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3129">Registration</a></li>
</ul>
Recent work undertaking using SICRIT technology for both targeted and untargeted food and feed monitoring tasks.
<h5>2. DataApex: Clarity Tips &amp; Tricks Webinar</h5>
<ul>
<li>Th, 18.1.2024, 09:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3350">Registration</a></li>
</ul>
Learn incredible tricks and tips for maximizing your experience with Clarity Chromatography Software. Dive into advanced functionalities and discover how to elevate your workflows.
<h5>3. Waters Corporation: Informatics series #13 Sample Weights in Empower</h5>
<ul>
<li>Th, 18.1.2024, 11:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3392">Registration</a></li>
</ul>
V této části si ukážeme různé možnosti přenosu hmotnosti vzorku do aplikace Empower.
<h5>4. Waters Corporation: Empower Tips: Ask Me Anything About Data Flow and Data Process Mapping with Data Governance in Mind</h5>
<ul>
<li>Th, 18.1.2024, 16:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3235">Registration</a></li>
</ul>
Please join us for a lively discussion as we explore data flow and data process mapping with data governance in mind.
<h5>5. Agilent Technologies: Error-Free Sample Preparation Workflows</h5>
<ul>
<li>Mo, 22.1.2024, 11:00 CET</li>
<li><a href="https://gcms.labrulez.com/webinar/3413">Registration</a></li>
</ul>
Agilent and METTLER TOLEDO have jointly developed an integrated workflow solution that addresses the most pressing root causes for laboratory failure investigations.
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<h3>The recommended procedure for H53 method integration in Clarity (method 1):</h3>
<ol>
<li>Use Baseline – Lock on the whole chromatogram.
</li>
<li>Apply Baseline – Allow Crossing to the whole chromatogram with the option To Start/End.
</li>
<li>Via Peak – Add positive, add the following peaks:
</li>
</ol>
<ul>
<li>A peak with the start time just before the solvent peak (this is the initial point of the baseline) and the end time at the beginning of the first fraction.</li>
<li>The first fraction (C10) peak with the start time exactly at the end time of the previous peak and the end time at the end of the fraction.</li>
<li>In a similar manner, i.e., with non-overlapping time frames, add the other peaks for remaining fractions (optionally, C10–C20, C20–C30, and C30–C40).</li>
</ul>
<ol start="4">
<li>Set Baseline – Together and Baseline – Forward horizontal over the entire chromatogram.
</li>
<li>Assign peaks to respective fractions using Force Peak Name (exact times are filled automatically when selecting the peak from the graph).
</li>
<li>Create a calibration file for the present fractions.
</li>
</ol>
When the chromatogram is integrated appropriately, you can use the Method - Save as Template command from the Chromatogram window to save the method as a template method, so it can be used for further measurements. In the case you have already measured all the samples, you can apply the integration on all your chromatograms via Analysis – Batch reprocess by method.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_How_to_determine_non_volatile_hydrocarbons_according_to_DIN_H53_ISO_16703_1_4d7e6aabf8/DataApex-How-to-determine-non-volatile-hydrocarbons-according-to-DIN-H53-(ISO-16703)-1.jpg" alt="DataApex - How to determine non-volatile hydrocarbons according to DIN H53 (ISO 16703)? 1"/>
Note: In the case, that the amounts of some compounds in standards are not known, it is necessary to set the Curve Fit Type to Free Calibration on the tabs of these compounds in the Calibration window.
<h4>Example of an evaluated chromatogram</h4>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_How_to_determine_non_volatile_hydrocarbons_according_to_DIN_H53_ISO_16703_2_9da75db54b/DataApex-How-to-determine-non-volatile-hydrocarbons-according-to-DIN-H53-(ISO-16703)-2.jpg" alt="DataApex - How to determine non-volatile hydrocarbons according to DIN H53 (ISO 16703) - 2"/>
<h3>An alternative procedure for H53 method integration in Clarity (method 2):</h3>
<ol>
<li>Use the same Peak Width and Threshold as in standard integration.
</li>
<li>Apply Baseline – Together to the whole chromatogram.
</li>
<li>Apply Baseline – Forward Horizontal to the whole chromatogram.
</li>
<li>Mark all the peaks between C10 and C40 as a group (the group boundary lines may exceed the C10 and C40 peaks, only fully contained peaks will be included).
</li>
<li>Amend the peak starts and ends by manual peak tools if necessary for the C10 and C40 (use the Peak - Both, with the A time corresponding to the respective C10 or C40 time and B time positive or negative, respectively. The times are relative, i.e., will be shifted accordingly in other chromatograms).
</li>
<li>Create calibration file for C10, C40, and Group A peaks.
</li>
</ol>
If the integration is not correct at this point (e.g., the integrated area for Group A between C10 and C40 peaks does not start/end exactly where the C10/C40 peaks end/start respectively, as shown in the figure below), an additional step might be added after step 3.: Apply again Baseline – Together to the whole chromatogram. Continue with the remaining steps.
To subtract a baseline, in the Method Setup – Advanced dialog, set the baseline chromatogram, and in the Matching, set No Change. The baseline file should be acquired on the stabilized system and preferably without injection of solvent or at least with a lower volume of the solvent. Otherwise, negative artifacts will appear, interfering with the correct baseline setting in Clarity later on.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_How_to_determine_non_volatile_hydrocarbons_according_to_DIN_H53_ISO_16703_3_cbe418722f/DataApex-How-to-determine-non-volatile-hydrocarbons-according-to-DIN-H53-(ISO-16703)-3.jpg" alt="DataApex - How to determine non-volatile hydrocarbons according to DIN H53 (ISO 16703) - 3"/>
<blockquote>
There is a condition that must be met:
</blockquote>
<blockquote>
<ul>
<li>The drawn baseline must not cross the chromatogram line (the negative areas arising do not have any physical meaning).</li>
</ul>
</blockquote>
This approach is generally less reliable and more sensitive to the choice of Integration Algorithm. 
<h4>Example of an evaluated chromatogram</h4>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_How_to_determine_non_volatile_hydrocarbons_according_to_DIN_H53_ISO_16703_4_46736a7950/DataApex-How-to-determine-non-volatile-hydrocarbons-according-to-DIN-H53-(ISO-16703)-4.jpg" alt="DataApex - How to determine non-volatile hydrocarbons according to DIN H53 (ISO 16703) - 4"/>
<h3>Sample data for Clarity</h3>
<ul>
<li><a href="https://downloads.dataapex.com/documentation/clarity/other/DIN_H53.zip">DIN_H53.zip</a> - zipped chromatograms, methods, and calibrations.</li>
<li><a href="https://downloads.dataapex.com/documentation/clarity/other/Din-H53-processed.dgz">Din-H53-processed.dgz</a> - archived Clarity Project to restore with Clarity via the Archive/Restore function</li>
</ul>

How to determine non-volatile hydrocarbons according to DIN H53 (ISO 16703)?

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How to determine non-volatile hydrocarbons according to DIN H53 (ISO 16703)?

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