<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 26th August 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p>
<blockquote>
<h4>👉 <a href="https://gcms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p>
</blockquote>
<p>This week we bring to you a posters from <a href="https://gcms.labrulez.com/events/568"><strong>ASMS 2024</strong></a> by <strong>LECO</strong>, <strong>Agilent Technologies</strong>,  <strong>Shimadzu</strong>, and <strong>Thermo Fisher Scientific</strong>!</p>
<h4><strong>1. LECO: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Long_Lifetime_Ion_Detector_GC_G_Cx_GC_TOFMS_MS_ASMS_24_LPSS_326_4c9e1fb7a1.pdf">A Novel Long-Lifetime Ion Detector for GC-TOFMS and GCxGC-TOFMS with Sub-Femtogram Detection Limits</a></strong></h4>
<ul>
<li>poster / <a href="https://gcms.labrulez.com/companies/296"><strong>ASMS 2024</strong></a></li>
</ul>
<p><strong>Introduction:</strong> Ion detection efficiency and fast response times are critical aspects of the ion detectors used in time-of-flight mass spectrometry (TOFMS). With modern advancements in ionization, ion optics, and ion transfer efficiency, TOFMS systems are capable of generating high ion flux onto the ion detectors. Having an ion detector that is capable of maintaining optimal performance over a long period of time while accepting high amounts of ion flux is a significant challenge in development of TOFMS instrumentation. Improvements in detector life will minimize maintenance costs and improve TOFMS user experience. A novel long-lifetime ion detector was developed in partnership with El Mul Technologies for use in LECO’s Pegasus® BTX GC and GCxGCTOFMS. The system was thoroughly evaluated for sensitivity and robustness, including longevity of the detector.</p>
<p><strong>Conclusions:</strong> The Pegasus BTX GC(GCxGC)-TOFMS with a novel Long-Lifetime Ion Detector has demonstrated the following performance characteristics:</p>
<ul>
<li>Sub-2 fg IDL for GC-TOFMS and Sub-fg IDL for GCxGC-TOFMS</li>
<li>Linear dynamic range of 5 orders of magnitude in GC-TOFMS and 4 orders of magnitude in GCxGC-TOFMS</li>
<li>Robust operation: the detector bias remains consistent and BTX peak intensity remains consistent over long periods of time, even with large numbers of samples acquired and significant amounts of charge accumulation on the detector.</li>
</ul>
<h4><strong>2. Thermo Fisher Scientific: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_153_dioxin_analysis_gc_orbitrap_capabilities_po153_asms2024_en_f72a355ee6.pdf">Meeting the challenges of Dioxin analysis and more with GC-Orbitrap high mass resolution capabilities</a></strong></h4>
<ul>
<li>poster / <a href="https://gcms.labrulez.com/companies/296"><strong>ASMS 2024</strong></a></li>
</ul>
<h5><strong>Abstract</strong></h5>
<p><strong>Purpose:</strong> Evaluate the performance of gas chromatography (GC) Orbitrap high mass resolution spectrometry for trace analysis of polychlorinated dibenzo-p-dioxins/furans (PCDD/PCDF) at current maximum allowable limits in soil according to EPA 1613 method criteria.¹ </p>
<p><strong>Method summary:</strong> Sample analysis was carried out on the Thermo ScientificOrbitrap Explorisᵀᴹ GC 240 mass spectrometer. A sample volume of 1.5 μL was injected for chromatographic separation using a TG-Dioxin (60 m × 0.25 mm, 0.25 μm) capillary GC column with a Thermo Scientific TRACE 1610 GC. Ion source conditions were optimized to fulfill sensitivity criteria of EPA 1613. Performance was evaluated through analysis of a raw soil extract previously analyzed using a regulatory compliant method². Quantification was performed using isotopic dilution in Thermo Scientific Chromeleon Chromatography Data System (CDS) software using the Dioxin Analyzer workflow . </p>
<p><strong>Results:</strong> The Orbitrap GC mass spectrometer fulfilled the high sensitivity, mass accuracy and resolution criteria of EPA 1613 at femtogram (fg) levels within a raw soil extract. Combined with a large dynamic range (0.05 – 100 pg•μL⁻¹), the OE GC provides users with an alternative analytical approach to deliver sensitive and accurate analysis of PCDD/F while enabling laboratories to meet future analytical challenges with high resolution accurate mass data.</p>
<h4><strong>3. Shimadzu: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Th_P_347_ASMS_Poster_Cafe_Ana_V6_239x117_03f5bcb26c.pdf">Ensuring food safety through the study of potential extractables and leachables in roasted coffee packaging by ultra-sensitive Headspace GC/MS</a></strong></h4>
<ul>
<li>poster / <a href="https://gcms.labrulez.com/companies/296"><strong>ASMS 2024</strong></a></li>
</ul>
<p><strong>Introduction</strong></p>
<ul>
<li>The main function of food product packaging is to protect food against any contaminant. However, in some circumstances, this packaging can release possible substances that pose a risk to human health. These are extractables and leachables (E&amp;L) compounds that migrate from materials into the product, especially under factors such as temperature, time, and solvents.</li>
<li>Notably, Brazilian legislation lacks a consolidated assessment to monitor these compounds in the food industry.</li>
<li>The Headspace Shimadzu HS-20 NX trap model allows the concentration of compounds, up to 10 times, in a trap material. This means that even very small traces of these contaminants can be detected and quantified accurately.</li>
<li>When coupled with GCMS-QP2020 NX (Fig.1), the HS-20 NX becomes a powerful tool for identifying and analyzing potential toxic contaminants, significantly contributing to food safety and compliance with quality regulations.</li>
</ul>
<p><strong>Conclusion</strong></p>
<ul>
<li>The use of HS-20 NX in Trap mode with GC/MS enabled the identification of over 100 compounds, comparing the spectra with the National Institute of Standard and Technology (NIST) library. Among these compounds are potential E&amp;L substances, as well as coffee aroma components.</li>
<li>This technique demonstrates high versatility and efficiency by providing high analytical sensitivity capable of identifying compounds even at low concentrations, something unachievable by conventional methods. This evolution represents a notable advancement in coffee and food quality control, enabling precise detection of essential characteristics and components to ensure the excellence of the final product and consumer health.</li>
</ul>
<h4><strong>4. Agilent Technologies: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Th_P_347_ASMS_Poster_Cafe_Ana_V6_239x117_03f5bcb26c.pdf">Faster Qualitative Analysis of Essential Oils Using GC/MS with Hydrogen Carrier Gas and a Hydrogen Optimized EI Source</a></strong></h4>
<ul>
<li>poster / <a href="https://gcms.labrulez.com/companies/296"><strong>ASMS 2024</strong></a></li>
</ul>
<p><strong>Introduction:</strong> Due to the price of helium (He), many laboratories are looking for alternative carrier gases for their gas chromatography/mass spectrometry (GC/MS) methods. This work describes the conversion of a GC/MS method for the identification of flavor and fragrance compounds in essential oils from helium to hydrogen (H₂). A single quadrupole GC/MS system was used with hydrogen carrier gas and an EI source optimized to provide spectral fidelity with hydrogen. To increase confidence in compound identifications, deconvoluted mass spectra and linear retention indices (RI) were searched against the NIST23 mass spectral library. A column and chromatographic conditions for hydrogen were chosen that reduce the analysis time by 2.5 times compared to the helium method and generates results comparable to helium.</p>
<p><strong>Conclusions:</strong> The data presented here shows that H₂ can successfully be used as a carrier gas for flavor and fragrance analyses with the proper conversion steps.</p>
<ul>
<li>The choice of the 20 m x 0.18 mm id x 0.18 µm film HP-5MSUI column allowed a 2.5 times faster analysis with equivalent chromatographic resolution.</li>
<li>The Method Translation calculator provided chromatographic conditions that maintained the same elution order as with the He method, resulting in excellent agreement of the RI values measured with both methods.</li>
<li>The use of MassHunter Unknowns Analysis software to deconvolute spectra and search them with RI filtering against the NIST23 library significantly simplified identification of the flavor components.</li>
<li>The HydroInert EI source minimized in-source reactions with H₂, resulting in higher LMS values.</li>
</ul>
<p>For further details on this work, please see reference 3. Reference 4 provides more information on flavor components that can react with H₂ in the source, and which benefit from the use of HydroInert. Note that if He is available at an acceptable price, it is the preferred carrier for GC/MS and should be used. However, as shown in this work, H2 can be used if appropriate method adjustments are made to accommodate its use.</p>


News from LabRulezGCMS Library - Week 35, 2024

<p><strong>In the next two weeks from September 9, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4></blockquote><blockquote><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Phenomenex: Solid Phase Extraction Method Development</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 10.9.2024 11:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4182">Registration</a></div></li></ul></div><p>Understand how to develop SPE methods from start to finish. Learn when and how to optimize SPE methods, and discover new tips and tricks to make SPE method development easier.</p></div><h5><strong>2. Agilent Technologies: Comprehensive Quality Control Testing of Biofuels to Ensure a Greener, more Sustainable Future</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 10:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4204">Registration</a></div></li></ul></div><p>Learn about the latest laboratory testing techniques that are used to ensure the quality, efficiency, and sustainability of modern biofuels.</p></div><h5><strong>3. Separation Science/Markes International: Advanced GC–MS Techniques in Polymer Chemistry</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 11:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4185">Registration</a></div></li></ul></div><p>Discover the latest trends and technologies in sampling and analysis of material emissions in the polymer industry.</p></div><h5><strong>4. Thermo Fisher Scientific: Discover the next generation of raw material ID testing for QA/QC</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 16:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4253">Registration</a></div></li></ul></div><p>Learn about the&nbsp;new features available in the TruScan G3 for pharmaceutical and biotechnology manufacturing QA/QC.</p></div><h5><strong>5. Agilent Technologies: Tips, Tricks, and Troubleshooting for Successful Headspace Analysis in GC</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 17:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/3915">Registration</a></div></li></ul></div><p>We go over the basics of headspace and how you can implement it successfully in the lab.</p></div><h5><strong>6. SGS: Clearing the Air: Understanding Airborne PFAS Exposure</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 19:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4219">Registration</a></div></li></ul></div><p>US EPA methods OTM45 and OTM-50, vapor intrusion, landfill gas monitoring, and the future of personal and occupational exposure monitoring.</p></div><h5><strong>7. Agilent Technologies: Alcoholic Beverages Virtual Symposium: Spirits</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 20:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4256">Registration</a></div></li></ul></div><p>How you can assure safety, authenticity, and quality of alcoholic beverages.</p><div class="sc-c459d889-0 fAWHTe"><strong>8. SelectScience: Master GC-MS analysis of volatile and semivolatile organic compounds</strong></div></div><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Th, 19.9.2024 17:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4223">Registration</a></div></li></ul></div><p>How to boost throughput with the use of an enhanced tuning algorithm, faster data acquisition, and other novel GC-MS designs.</p></div>

Webinars LabRulezGCMS Week 37-38/2024

Quantitative determination of olefins in pyrolysis oils from waste plastics and tires using selective adsorption by Ag–SiO2 followed by GC×GC-FID

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 2nd September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><h4>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></a></h4></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring to you applications and technical notes by <strong>Agilent Technologies</strong>, <strong>Shimadzu</strong>, and <strong>Thermo Fisher Scientific</strong>!</p><h4><strong>1. Shimadzu: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00738_en_be6d7795f2.pdf"><strong>Residual NMP and Solvent Analysis in Lithium-ion Battery Cathode</strong></a></h4><ul><li>application</li></ul><p><strong>User Benefits</strong></p><ul><li>Analyze residual NMP and similar solvent structures in the cathode of lithium-ion batteries.</li><li>Optimize drying conditions in the cathode manufacturing process and quantify the amount of residual solvents for quality control.</li><li>Minimize equipment footprint by combining Brevis GC-2050 and GCMS-QP2050.</li></ul><p><strong>Introduction:</strong> Lithium-ion batteries (LiB) consist of cathode and anode, electrolyte, separator, etc. The electrodes are formed by coating a slurry of active material, conductive additives, binders, etc., mixed<br>in an organic solvent, on a metal film (current collector) and then dried. N-Methyl-2-pyrrolidone (NMP) is known as an organic solvent used in solvent-based slurries, and especially for quality control of the cathode, the residual amount of NMP in the cathode is examined during the drying process.</p><p>In this application, a simple analysis method for residual NMP in the cathode of lithium-ion battery NCM (nickel-cobalt-manganese ternary material) using GC-FID with headspace method is introduced. In addition, results of qualitative analysis of other solvents remaining in the NCM cathode using GC-MS and<br>comparison of residual solvent amounts in five different cathodes with different drying processes are also presented.</p><p><strong>Summary: </strong>By using headspace GC-FID, it is possible to easily analyze residual NMP in the cathode and quantify residual solvents without the need for preprocessing. Additionally, with headspace GC-MS, qualitative analysis of residual organic solvents can also be performed.</p><p>Using compact models such as Brevis GC-2050 or GCMS-QP2050 allows for minimization of experimental space and detailed analysis of solvent analysis for each drying process. This can be applied to quality control and research and development in the cathode manufacturing process.</p><h4><strong>2. </strong><style type="text/css"></style><span style="font-family:Arial;"><span style="font-style:normal;font-weight:normal;" data-sheets-root="1"><strong>Agilent Technologies</strong></span></span><strong>: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_forensic_triple_quad_mrm_database_toxicological_5994_7594en_agilent_0dbf3ad769.pdf"><strong>A Forensic Triple Quadrupole GC/MS MRM Database for Forensic and Toxicological Workflows</strong></a></h4><ul><li>application</li></ul><p><strong>Abstract:</strong> Systematic toxicological analysis is crucial in forensic laboratories, requiring robust and reliable analytical methods. Gas chromatography coupled to triple quadrupole mass spectrometry (GC/TQ) is a versatile and widely used technique that provides uniform results across instruments and laboratories. The aim of this study was to establish a database of multiple reaction monitoring (MRM) transitions for<br>toxicologically relevant compounds amenable to GC/MS. The resulting curated database includes 176 entries, including 154 unique compounds with up to 12 transitions per compound. The database allows for instantly building methods for targeted screening and confident quantitation of GC-amenable, forensic, and toxicologically relevant compounds.</p><p>The database is available for download as a CSV file in Appendix 1 of this application note.</p><p><strong>Conclusion:</strong> The forensic toxicology database, with a curated set of 1,803 MRM transitions for 176 toxicologically relevant compounds, was successfully developed. The compounds included &nbsp;benzodiazepines, antidepressants, opioids, and drugs of abuse. The application of this MRM method to<br>an authentic real-world sample showcased its ability to detect and quantitate toxicants at trace levels due to the high sensitivity and selectivity of the MS/MS approach. This approach addresses limitations when relying solely on full scan data acquisition mode.</p><p>The developed MRM database can be used for simplified data acquisition method creation, providing a valuable resource for the development of screening and quantitation methods in forensic labs. The developed MRM curation workflow showed promise for continuous expansion, offering a uniform and practical approach for adding new chemicals to the database.</p><h4><strong>3. </strong><style type="text/css"></style><span style="font-family:Arial;"><span style="font-style:normal;font-weight:normal;" data-sheets-root="1"><strong>Agilent Technologies</strong></span></span><strong>: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_hydroinert_ei_source_functionality_longevity_5994_7680en_agilent_991ba3a869.pdf"><strong>Optimizing HydroInert EI Source Functionality and Longevity</strong></a></h4><ul><li>technical note</li></ul><p><strong>Introduction: </strong>The benefits of hydrogen in gas chromatography (GC) are widely accepted, as it can be generated in the lab in a cost-effective manner, produces fast chromatography, and allows for higher sample throughput. Since hydrogen is a reactive gas, hydrogenation and dechlorination reactions can and do occur in the mass spectrometer electron ionization (EI) source. These reactions can make applying hydrogen carrier gas to many applications difficult. A specially designed extractor source for the Agilent Inert Plus GC/MSD and triple quadrupole GC/MS systems address these hydrogen-related issues and improves performance with hydrogen carrier gas. The Agilent HydroInert source (Figure 1) with H<sub>2</sub> carrier gas retains mass spectral fidelity and can allow users to continue to use existing helium-based mass spectral libraries.</p><p>When adopting hydrogen for GC/MS analysis, there are several factors to consider. First, hydrogen is a reactive gas, and it may potentially cause chemical reactions in the inlet, column, and sometimes the MS EI source, which can change analysis results. To address potential issues in the MS source while using hydrogen, the HydroInert source was used. Additional information can be found in the Agilent technical overview of the HydroInert source.<sup>1</sup> Second, for GC/MS applications, hardware changes in the gas chromatograph and mass spectrometer are recommended when switching to hydrogen carrier gas. The Agilent Helium to Hydrogen Carrier Gas Conversion Guide<sup>2</sup> describes in detail the steps for conversion from helium to hydrogen carrier gas. Lastly, it is recommended that when working with flammable or explosive gases, laboratories maintain proper safety in gas handling and use. Further information on the<br>safe use of hydrogen can be found in the Agilent Hydrogen Safety Manual<sup>3</sup> and Hydrogen Safety for the Agilent GC System Guide.<sup>4,5</sup></p><p><strong>Conclusion:</strong> Agilent HydroInert source longevity is dependent on application and method conditions. However, by using some of the best practices highlighted above, the longevity of HydroInert parts can be prolonged. The HydroInert source cannot be mechanically or chemically cleaned, thus when source parts show reduced functionality, replacement of the recommended parts above is required to restore functionality. Replacement intervals will be method- and application-dependent.</p><h4><strong>4. </strong><style type="text/css"></style><span style="font-family:Arial;"><span style="font-style:normal;font-weight:normal;" data-sheets-root="1"><strong>Thermo Fisher Scientific</strong></span></span><strong>: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/AN_002784_Improvements_for_the_analysis_of_volatile_VOC_and_very_volatile_VVOC_organic_compounds_using_In_Tube_Extraction_Dynamic_Headspace_ITEX_DHS_and_cryogen_free_refocusing_4_bd362df5a5.pdf"><strong>Improvements for the analysis of volatile (VOC) and very volatile (VVOC) organic compounds using In-Tube Extraction- Dynamic Headspace (ITEX-DHS) and cryogen-free refocusing</strong></a></h4><ul><li>application</li></ul><p><strong>Goal: </strong>To demonstrate how the technological development of dynamic headspace extraction/enrichment techniques, such as ITEX-DHS (In-Tube Extraction-Dynamic Headspace) coupled to a cryogen-free refocusing in the PTV injector, enables the achievement of lower detection limits for volatile and very volatile organic compounds.</p><p><strong>Keywords:</strong> VOC, VVOC, water, dynamic headspace, ITEX-DHS, refocusing, PTV, TRACE 1610 GC, TriPlus RSH SMART autosampler</p><p><strong>Conclusion:</strong> The use of the ITEX-DHS technique for headspace enrichment coupled to cryogen-free refocusing into the PTV injector is a suitable approach for trace level analysis of VOC and VVOC in water samples, offering a clean method to comply with more stringent regulatory limits of quantitation.</p><ul><li>Combined with refocusing prior to transfer into the column and SIM acquisition mode, the ITEX-DHS technique achieves limits of quantification at low ppt levels and extrapolated limits of detection in the sub-ppt range, even for VVOC such as vinyl chloride, with high recovery precision (&lt;5% RSD) and a linear response over four orders of magnitude.</li><li>ITEX-DHS offers a flexible enrichment technique capable of handling low and high concentrated samples to comply with different sensitivity requirements.</li><li>The complete workflow, from method set up to data processing and reporting, can be fully controlled through Chromeleon CDS, which greatly facilitates operations on a day-to-day basis.</li></ul>

News from LabRulezGCMS Library - Week 36, 2024

Simple on-site extraction and GC-MS analysis of rotenone and degradation products for monitoring invasive fish eradication treatments in fresh and brackish waters

<p><strong>In the week from September 16, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4></blockquote><blockquote><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Agilent Technologies: Comprehensive Quality Control Testing of Biofuels to Ensure a Greener, more Sustainable Future</strong></h5><ul><li>Tu, 17.9.2024 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4204">Registration</a></li></ul><p>Learn about the latest laboratory testing techniques that are used to ensure the quality, efficiency, and sustainability of modern biofuels.</p><h5><strong>2. Separation Science/Markes International: Advanced GC–MS Techniques in Polymer Chemistry</strong></h5><ul><li>Tu, 17.9.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4185">Registration</a></li></ul><p>Discover the latest trends and technologies in sampling and analysis of material emissions in the polymer industry.</p><h5><strong>3. Waters Corporation: Empower Tips: Ask Me Anything About Processing Data - Part 1</strong></h5><ul><li>Tu, 17.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4288">Registration</a></li></ul><p>In the first part of this webinar series, we will explore the algorithms and learn how to set the parameters in a logical fashion.</p><h5><strong>4. Thermo Fisher Scientific: Discover the next generation of raw material ID testing for QA/QC</strong></h5><ul><li>Tu, 17.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4253">Registration</a></li></ul><p>Learn about the&nbsp;new features available in the TruScan G3 for pharmaceutical and biotechnology manufacturing QA/QC.</p><h5><strong>5. Agilent Technologies: Tips, Tricks, and Troubleshooting for Successful Headspace Analysis in GC</strong></h5><ul><li>Tu, 17.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/3915">Registration</a></li></ul><p>We go over the basics of headspace and how you can implement it successfully in the lab.</p><h5><strong>6. SGS: Clearing the Air: Understanding Airborne PFAS Exposure</strong></h5><ul><li>Tu, 17.9.2024 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4219">Registration</a></li></ul><p>US EPA methods OTM45 and OTM-50, vapor intrusion, landfill gas monitoring, and the future of personal and occupational exposure monitoring.</p><h5><strong>7. Agilent Technologies: Alcoholic Beverages Virtual Symposium: Spirits</strong></h5><ul><li>Tu, 17.9.2024 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4256">Registration</a></li></ul><p>How you can assure safety, authenticity, and quality of alcoholic beverages.</p><h5><strong>8. SelectScience: Master GC-MS analysis of volatile and semivolatile organic compounds</strong></h5><ul><li>Th, 19.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4274">Registration</a></li></ul><p>How to boost throughput with the use of an enhanced tuning algorithm, faster data acquisition, and other novel GC-MS designs.</p>

Webinars LabRulezGCMS Week 38/2024

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 9th September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring to you applications by <strong>Agilent Technologies</strong>, <strong>Shimadzu</strong>, and <strong>Thermo Fisher Scientific</strong> and poster by <strong>LECO</strong> from ACS meeting!</p><h4><strong>1. Thermo Fisher Scientific: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_002952_gc_ms_isq_environmental_an002952_na_en_9738609742.pdf"><strong>Adhering to U.S. EPA Method 524.2 for the analysis of volatile organic compounds in drinking water</strong></a></h4><ul><li>application</li></ul><p><strong>Goal: </strong>Demonstration of a routine analytical method that meets the requirements outlined in U.S. EPA 524.2 for the quantitation of volatile organic compounds (VOCs) in drinking water, using the Teledyne LABS Tekmar Lumin Purge and Trap (P&amp;T) concentrator paired with the AQUATek LVA autosampler system along with a Thermo Scientific™ ISQ™ 7610 MS system coupled with a Thermo Scientific™ TRACE™ 1610 gas chromatograph (GC) and Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS). Method linearity, method detection limit (MDL), precision, and accuracy were assessed to evaluate method performance.</p><p><strong>Introduction:</strong> Analytical testing labs play a crucial role in monitoring surface, ground, and drinking water for volatile organic compounds (VOCs). Common by-products in the processing of household and industrial products, VOCs can contaminate water sources, potentially harming the environment and public health. To safeguard against this, labs use the U.S. EPA Method 524.21 to test water for the presence of VOCs, including four trihalomethane disinfection by-products. This procedure utilizes Purge and Trap (P&amp;T) procedures to remove VOCs with high volatility and low water solubility from water samples, followed by gas chromatography-mass spectrometry (GC-MS).</p><p><strong>Conclusion:</strong> The TRACE 1610 GC, the ISQ 7610 system, and the Tekmar Lumin P&amp;T with the AQUATek LVA autosampler system together offer benefits for executing U.S. EPA Method 524.2. The Tekmar Lumin P&amp;T concentrator enhances sample throughput through efficient trap cooling and moisture control, thus reducing peak interference and extending GC column life. The ISQ 7610 system’s VPI and ExtractaBrite ion source allow ionization source and analytical column replacement without venting the instrument, ensuring minimal downtime, and the XLXR™ detector offers extended linear dynamic range. The collective technology addresses routine VOC analysis challenges, ensuring robust sensitivity, maximized output, and consistent method compliance. The ISQ 7610 system equipped with the VPI coupled with the Tekmar Lumin P&amp;T and the AQUATek LVA autosampler exceeds all the requirements outlined in U.S. EPA Method 524.2 for analysis of VOCs in drinking water:</p><ul><li>Excellent linearity for all compounds was demonstrated with the %RSD of the calibration response factors passing all method requirements.</li><li>MDL and precision for seven 0.5 ppb standards showed no interference from excessive water and produced very reproducible results. The average MDL result for all 83 target compounds was 0.06 ppb with a precision of 4.06%.</li><li>The precision for n=31 samples over 189 injections displayed &lt;30% RSD accuracy for all compounds as the method requires. The average precision for all 83 target compounds and 2 surrogates gave a %RSD of 6.43% with an accuracy of 98% recovering the compounds. Individually, 4-bromofluorobenzene and 1,2-dichlorobenzene-d4 had a 7.68% RSD with an accuracy of 98% and 4.95% RSD and an accuracy of 95%, respectively, over 189 injections and almost four days of uninterrupted analysis.</li></ul><h4><strong>2. Shimadzu: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00706_en_f95bd4b605.pdf"><strong>Analysis of Denatured Fuel Ethanol with Brevis GC-2050 Using ASTM D5501</strong></a></h4><ul><li>application</li></ul><p><strong>User Benefits</strong></p><ul><li>The compact design of the Brevis GC-2050 enables space-saving in the laboratory.</li><li>As an alternative gas for helium, hydrogen can be used as the carrier gas.</li><li>&nbsp;Analysis of ethanol and methanol in fuels based on ASTM D5501 is possible.</li></ul><p><strong>Introduction</strong></p><p>Bioethanol has attracted attention as a form of renewable energy which can be obtained from biomasssuch as corn and sugar cane. ASTM D5501 provides a test method for determination of the concentrations of ethanol and methanol in fuels for concentrations of ethanol from 20 to 100 wt% and concentrations of methanol from 0.01 to 0.6 wt%.</p><p>In this Application News article, measurements of the purity of ethanol containing gasoline as a denaturant as specified in ASTM D5501 were carried out with a Brevis GC-2050 gas chromatograph, using helium and hydrogen asthe carrier gases.</p><p><strong>Conclusion</strong></p><p>Ethanol purity tests were carried out as provided in ASTM D5501 using a Brevis GC-2050 gas chromatograph. The splitter linearity test showed no inlet discrimination so that accurate qualitative analysis could be made for denatured fuel ethanol with the wide boiling range components regardless of whether helium or hydrogen was used as the carrier gas.</p><h4><strong>3. Agilent Technologies: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_aldehydes_beer_pal3_autosampler_5977c_gc_msd_5994_7633en_agilent_1fe3b8541c.pdf"><strong>Analysis of Aldehydes in Beer by Agilent PAL3 Autosampler and 5977C GC/MSD</strong></a></h4><ul><li>application</li></ul><p><strong>Abstract</strong></p><p>This application note describes a method for quantitation of four aldehydes (hexanal, furfural, phenylacetaldehyde, and trans-2-nonenal) responsible for off-flavors in beer using an Agilent 8890/5977C GC/MSD with an Agilent PAL3 (SPME) autosampler. The method used fully automated, solvent-free extraction and on-fiber derivatization. The aldehyde compounds were derivatized with the derivatization agent O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) using the on-fiber derivatization procedure. The derivatization agent was first adsorbed onto an Agilent 65 µm PDMS/DVB fiber. Next, the fiber was inserted into a 20 mL headspace vial containing a 2 mL beer sample with agitation at 60 °C for 30 minutes. Both extraction and derivatization procedures were automatically performed using the PAL3 autosampler. The method demonstrated excellent sensitivity, with detection limits of 0.0009 µg/L for hexanal, 0.52 µg/L for furfural, 0.015 µg/L for phenylacetaldehyde, and 0.003 µg/L for trans-2-nonenal. The limits of the quantification for the four compounds were 0.003, 1.72, 0.05, and 0.01&nbsp;µg/L, respectively. The four aldehydes were successfully quantified in four beer samples purchased from a supermarket. Good repeatability was demonstrated with RSD &lt; 4.9% based on three replicate injections of the four beer samples for all four&nbsp;aldehydes.</p><p><strong>Conclusion</strong></p><p>This application note describes the quantitative analysis of four aldehydes (hexanal, furfural, phenylacetaldehyde, and trans-2-nonenal) responsible for off-flavors in beer using an Agilent 8890/5977C GC/MSD with a PAL3 (SPME) autosampler. This method offers the advantages of full automation, rapid analysis, solvent-free extraction, and on-fiber derivatization. With this automated solution, excellent sensitivity was demonstrated for the detection of hexanal (0.0009 μg/L), furfural (0.52 μg/L), phenylacetaldehyde (0.015&nbsp;μg/L), and trans-2-nonenal (0.003 μg/L). Four different brands of beer were analyzed, with hexanal detected in the range of 0.45 to 1.56 μg/L, furfural in the range of 6.62&nbsp;to 50.37 μg/L, phenylacetaldehyde in the range of 6.64 to 10.51&nbsp;μg/L, and trans-2-nonenal in the range of 0.031 to 0.062&nbsp;μg/L. Good repeatability was demonstrated with RSD&nbsp;&lt;&nbsp;4.9% based on three replicate injections of the four beer samples for all four aldehydes.</p><h4><strong>4. LECO: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/hf_acs21_lpss_284_c35134b9cd.pdf"><strong>Combining GC with MS and Olfactory Detection for a Variety of Food, Flavor, and Fragrance Analyses</strong></a></h4><ul><li>Poster / <strong>ACS</strong></li></ul><p><strong>INTRODUCTION</strong></p><p>Gas chromatography (GC) coupled with mass spectrometry (MS) is an important tool for the characterization of a wide range of food, flavor, and fragrance samples. The components most likely to contribute to the aroma of a sample tend to be volatile and semi-volatile analytes, and GC-MS is well-suited for this type of analysis. Complex samples are effectively separated into the individual analyte components with GC. Time-of-Flight (TOF) MS detection provides important information towards the identification of these potentially important components of the sample with full m/z range data that can be library searched and that is also optimal for deconvolution algorithms. The incorporation of olfactory (O) detection with this data is particularly helpful for connecting the identified features with their contributions to the overall aroma or flavor. This type of sensory directed analysis highlights regions of interest and leads to specific analytes of interest for a focused review of the data. This combination of tools can separate and identify analytes and then determine those that are most important for contributing to the sensory characteristics of the sample. A variety of samples were analyzed with this combination of tools, and the benefits of using the information together are highlighted.</p><p><strong>CONCLUSIONS</strong></p><p>In this work, the combination of a GC separation with MS and O for detection provided a powerful and efficient analytical platform to isolate individual analytes, identify those isolated analytes, and connect them to their sensory impacts. The olfactory data allowed for sensory directed analysis. In each case, the GC separation and full m/z range TOFMS data were crucial for determining the identification of the feature responsible for the characteristic aroma. This collection of tools was demonstrated for the characterization of the most aroma impacting components of a nutmeg essential oil, the distinction of sensory differences in cilantro, and the determination of an off-odor in beer.</p>

News from LabRulezGCMS Library - Week 37, 2024

Comprehensive methodology for semi-volatile organic compound determination in ambient air with emphasis on polycyclic aromatic hydrocarbons analysis by GC–MS/MS

<p><strong>In the week from September 23, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4></blockquote><blockquote><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1.&nbsp;Mettler-Toledo: Automated Data Management for LC/GC Workflows</strong></h5><ul><li>Mo, 23.9.2024 10:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4226">Registration</a></li></ul><p>How can you support digitalized and scalable sample preparation processes for better chromatography results.</p><h5><strong>2. Agilent Technologies: PFAS in Food Supply Chains: Regulations and Analytical Approaches: in association with AOAC India Section</strong></h5><ul><li>Tu, 24.9.2024 08:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4281">Registration</a></li></ul><p>PFAS characteristics and the challenges they present to food safety.</p><h5><strong>3. Waters Corporation: Chromatography - APGC</strong></h5><ul><li>Tu, 24.9.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4307">Registration</a></li></ul><p>Discover the advantages of GC coupled to MS under atmospheric pressure (Atmospheric Pressure GC/ APGC) as a powerful alternative to electron ionization (EI) for GC-MS.</p><h5><strong>4. Agilent Technologies: Alcoholic Beverages Virtual Symposium: Wine</strong></h5><ul><li>Tu, 24.9.2024 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4259">Registration</a></li></ul><p>How you can assure safety, authenticity, and quality of alcoholic beverages.</p><h5><strong>5. Waters Corporation: General Sample Preparation</strong></h5><ul><li>We, 25.9.2024 09:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4308">Registration</a></li></ul><p>Join us in exploring SPE key parameters and best practices for implementing successful SPE methods.</p><h5><strong>6. Waters Corporation: Automated Sample Preparation</strong></h5><ul><li>We, 25.9.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4309">Registration</a></li></ul><p>The Andrew+™ pipetting robot offers fully automated liquid handling using electronic pipettes and labware holders.</p><h5><strong>7. Agilent Technologies: Sample Cleanup: Method Development for Solid Phase Extraction and Beyond</strong></h5><ul><li>We, 25.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/3917">Registration</a></li></ul><p>We’ll discuss tips for selecting, developing, and implementing SPE methods. We’ll also discuss newly developed targeted filtration options and their benefits.</p><h5><strong>8. LECO: Non-Targeted Screening in Sustainable Fuels: Exploring Method Development and Fuel Quality Assessment Using GCxGC-MS and Hyphenated Techniques</strong></h5><ul><li>Th, 26.9.2024 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4296">Registration</a></li></ul><p>Embark on a journey of discovery in chemical analysis, with each instalments of our monthly webinar series delivering fresh perspectives and invaluable insights.</p>

Webinars LabRulezGCMS Week 39/2024

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 16th September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring to you applications and other documents by <strong>Agilent Technologies</strong>, <strong>Shimadzu</strong>, <strong>Thermo Fisher Scientific,</strong> and <strong>LECO</strong>!</p><h4><strong>1. Shimadzu: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c146_e452_c8a53d60a2.pdf"><strong>Database for GC-MS(/MS) Aroma Analysis - Smart Aroma Database</strong></a></h4><ul><li>Brochure</li></ul><p><strong>Provides Efficient and Accurate Aroma Analysis Using GC-MS(/MS)</strong></p><p>Information on more than 500 compounds that contribute to aroma is registered in Smart Aroma Database™, enabling the objective evaluation and analysis of aroma compounds using GC-MS(/MS).</p><p>1. Automatically Detects Aroma Compounds from Scan Measurements with High Accuracy</p><p>2. Easily Narrows Down the Compounds that Contribute to the Aroma</p><p>3. Enables High-Sensitivity Target Analysis Using MRM and SIM</p><p>4. Supports a Variety of Systems</p><h4><strong>2. Agilent Technologies: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_5q_gc_column_campaign_5994_7596en_agilent_baca38e505.pdf"><strong>Agilent J&amp;W DB-5Q and HP-5Q GC columns</strong></a></h4><ul><li>Brochure</li></ul><h5><strong>Get the Most from Your MS</strong></h5><p><strong>As mass spectrometry continues to push the boundaries of sensitivity and speed, you need a column that can do the same</strong></p><ul><li>Agilent J&amp;W 5Q GC columns are designed to ensure optimal analyte delivery to your quadrupoles. They combine industry-leading ultra inert performance with ultra low-bleed technology, setting a new standard for GC/MS column reliability and productivity.</li><li>Ultra low-bleed performance enhances data accuracy with high spectral fidelity and stable baseline integration.</li><li>Ultra inert performance increases sensitivity for active, trace-level analytes and provides balanced deactivation for multiclass analyte panels.</li><li>Ultrafast conditioning and outstanding column durability improve uptime by minimizing the frequency of column changes.</li><li>Identical selectivity to current 5ms columns simplifies adaptation to existing retention time libraries and retention time locking.</li><li>Compatibility with any GC/MS system ensures a seamless fit for all Agilent GC platforms. Agilent J&amp;W 5Q GC columns are available in high-efficiency, hydrogen-compatible, and backflushing dimensions.</li></ul><h4><strong>3. Thermo Fisher Scientific: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/AN_002784_Improvements_for_the_analysis_of_volatile_VOC_and_very_volatile_VVOC_organic_compounds_using_In_Tube_Extraction_Dynamic_Headspace_ITEX_DHS_and_cryogen_free_refocusing_4_bd362df5a5.pdf"><strong>Improvements for the analysis of volatile (VOC) and very volatile (VVOC) organic compounds using In-Tube Extraction-Dynamic Headspace (ITEX-DHS) and cryogen-free refocusing</strong></a></h4><ul><li>Application</li></ul><p><strong>Goal</strong></p><p>To demonstrate how the technological development of dynamic headspace extraction/enrichment techniques, such as ITEX-DHS (In-Tube Extraction-Dynamic Headspace) coupled to a cryogen-free refocusing in the PTV injector, enables the achievement of lower detection limits for volatile and very volatile organic compounds.</p><p><strong>Introduction</strong></p><p>Volatile organic compounds (VOCs) are a group of organic chemicals with low vapor pressure that can easily evaporate into the air, even at room temperature. These compounds can originate from various sources, including industrial processes, vehicle emissions, and natural sources. While VOCs are often associated with air pollution, they can also contaminate water, thus posing potential risks to human health and the environment.<sup>1</sup> VOCs can enter water through direct discharges, atmospheric deposition, or runoff from contaminated areas. Common VOCs found in water include benzene, toluene, ethylbenzene, and xylene (BTEX), as well as chlorinated compounds such as trichloroethylene (TCE) and tetrachloroethylene (PCE). These compounds can cause adverse health effects, ranging from short-term irritation to long-term chronic conditions, depending on the concentration and duration of exposure.</p><p>Regulatory authorities all over the world have established limits to control the maximum amount of VOCs in drinking water, groundwater, or surface water (e.g., Safe Drinking Water Act (SDWA) in the USA or the European Directive 2008/105/EC).<sup>2,3</sup> Therefore, monitoring and analyzing VOCs in water play crucial roles in identifying and addressing potential contamination issues, guiding remediation efforts, and ensuring compliance with water quality regulations.<sup>4</sup></p><p>Common methods to analyze VOCs in water include headspace, purge and trap, solid-phase microextraction, and liquid-liquid<br>extraction as possible sample preparation techniques employed to extract and concentrate VOCs before GC-MS analysis. As technology advances, continuous improvements in analytical methods and instrumentation contribute to more accurate and efficient VOC analysis, enhancing the ability to safeguard water resources and public health.</p><p>When dealing with drinking water testing, the limits of detection are particularly challenging, requiring an efficient enrichment before GC-MS analysis.</p><p>In-Tube Extraction-Dynamic Headspace (ITEX-DHS) is a sample preparation technique for the extraction and preconcentration of volatile compounds from different matrices, such as water, soil, or biological samples. One of the key advantages of ITEX-DHS is its high sensitivity and selectivity for volatile compounds. It allows for the extraction of low concentrated analytes from complex matrices while minimizing interference from non-volatile matrix components. Additionally, the technique offers an automated and efficient sampling process through a robotic autosampler, making it suitable for unattended and time-sensitive analyses.</p><p>ITEX-DHS has found applications in various fields, including environmental monitoring, food analysis, and forensic science. Its versatility makes it particularly valuable in situations where trace-level analysis of volatile compounds is crucial. An example of the use of ITEX-DHS for the detection of odorants in water at ng/L level is reported in a previous application note.<sup>5</sup></p><p>In this study, the performance of the ITEX-DHS sampling technique has been evaluated for trace level detection of volatile and very volatile compounds (VVOCs) in water, in combination with peak refocusing into a Programmed Temperature Vaporizer (PTV) injector, to enhance peak shape and signal-to-noise ratio.</p><h4><strong>4. LECO: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/PEGBTX_EXPAND_YOUR_PFAS_ANALYSIS_203_821_689_d24746e8bb.pdf"><strong>Expand Your PFAS Analysis - Screen for Targets and Identify Unknowns Simultaneously</strong></a></h4><ul><li>Application</li></ul><p><strong>Key Words:</strong> PFAS, GC-MS, HR-MS, TOFMS, Environmental Analysis, Pollutants, Emerging Substances, Non-target, NTS, Screening</p><p><strong>Background and Description</strong></p><p>Research into the prevalence of er- and polyfluoroalkyl substances (PFAS)—also known as “forever chemicals” due to theirp high stability in our environment and food chain continues to grow. At the same time, regulatory control of these species in our water and food supplies continues to gain momentum. However, analysis of PFAS in complex environmental samples can be challenging due to the enormous number and variety of PFAS chemicals. New analytical methods must be developed to monitor PFAS in the environment.</p><p>This application focuses on the rapidly expanding area of PFAS analysis and highlights how screening for known PFASnote targets, as well as discovering and identifying unknown PFAS chemicals, can be performed using high-performance GC-TOFMS. New libraries are being developed to facilitate the screening of these pollutants in samples.</p><p><strong>Conclusion</strong></p><p>Meeting the growing environmental research and regulatory needs for PFAS analysis requires the use of powerful technologies to screen for known targets and to detect and identify unknown PFAS candidates. Here, sub-nominal mass GC-TOFMS, allowed simultaneous, full mass range, highly sensitive target, and NTS screening for PFAS in Anti-Fog/Demisting products, detecting a variety of both known PFAS and unknown PFAS candidates. The use of accurate mass GC-HR-TOFMS technology with EI and CI capabilities facilitated strong tentative identifications of the unknowns to be a class of fluorotelomer ethoxylates (FTEOs). This approach, together with the results obtained, suggests these technologies are an ideal choice for screening and identification of volatile and semi-volatile PFAS, in an array of sample types in complex matrices.</p>

News from LabRulezGCMS Library - Week 38, 2024

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