GCMS
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike
Author
Washington University in St. Louis
Washington University in St. Louis is a place where people matter and serious work is done. Our mission is to discover and disseminate knowledge, and to protect the freedom of inquiry through research, teaching and learning. We are a community where you can be an individual and achieve exceptional things. We are committed to learning and exploration, to discovery and impact.
Tags
Article
Various
Video
Logo of LinkedIn

WashU leads new multi-omics production center for NIH research consortium

The National Institutes of Health (NIH) is channeling $50.3 million over the next five years into a new consortium dedicated to advancing the generation and analysis of multi-omics data.
Video placeholder
  • photo: Washington University in St. Louis/Shutterstock: WashU leads new multi-omics production center for NIH research consortium
  • video: Cambridge Isotope Laboratories: Isotope Day 2021 - Gary Patti - g Data from Heavy Molecules

Researchers will analyze materials from six disease study sites across US

Multi-omics is a research approach that leverages the power of several different “omics” data types at once to build a detailed picture of factors that contribute to human health and disease.

The National Institutes of Health (NIH) is channeling $50.3 million over the next five years into a new consortium dedicated to advancing the generation and analysis of multi-omics data for human health research. As part of this team, Washington University in St. Louis is establishing and will lead a central production center that functions as a hub for multi-omics analyses for materials from consortium members at each of six disease study sites identified by the NIH.

Gary Patti, the Michael and Tana Powell Professor of Chemistry in Arts & Sciences and a professor of medicine and of genetics at the School of Medicine, and Ting Wang, head of the Department of Genetics at the School of Medicine and the Sanford C. and Karen P. Loewentheil Distinguished Professor of Medicine, are principal investigators with the new consortium. Patti, who recently founded a multi-omics company called Panome Bio, is an innovator in multi-omics research, and Wang is involved in multiple other NIH consortia, such as the Human Pangenome Reference Consortium.

Washington University in St. Louis: WashU leads new multi-omics production center for NIH research consortium: Patti

Collaborators will take advantage of cutting-edge resources at Washington University, such as the Center for Proteomics, Metabolomics, and Isotope Tracing on the Danforth Campus. The university estimates the value of its portion of the new grant at $19.2 million.

Most human diseases have complex origins that are influenced by a combination of genetic and environmental components such as diet, physical activity, exposure to pollutants and social determinants,” Patti said. “We are working to understand how disease develops in a person by studying the flow of molecular information at multiple levels of ‘omics’ in parallel.”

This consortium model eliminates one important barrier to progress by making it easier to collect multi-omics data from the same sets of samples and developing collaborative teams with the appropriate expertise to harmonize and integrate the results,” he said.

A more holistic view

Multi-omics incorporates several “omics” data types, including genomics, epigenomics, transcriptomics, proteomics and metabolomics. Each of these data types reveals distinct information about different aspects of a biological system, and leveraging all these data types at once is becoming increasingly possible with advances in high-throughput technologies and data science.

The integration of multiple types of data from an individual participant’s biological sample can provide a more holistic view of the molecular factors and cellular processes involved in human health and disease, including untangling genetic and non-genetic factors in health and disease. This approach offers great promise in areas such as defining disease subtypes, identifying biomarkers and discovering drug targets.

Washington University in St. Louis: WashU leads new multi-omics production center for NIH research consortium: Wang

With each additional layer of omics information comes more clues about biology,” Wang said. “I’m really excited about the work we will do in this consortium to integrate genomics, proteomics and metabolomics data. This is the future of systems biology.

Beyond gaining insights into individual diseases, the primary goal of this consortium is to develop scalable and generalizable multi-omics research strategies as well as methods to analyze these large and complex datasets,” said Joannella Morales, a National Human Genome Research Institute (NHGRI) program director involved in leading the consortium. “We expect these strategies will ultimately be adopted by other research groups, ensuring the consortium’s work will have broad and long-lasting impacts for clinical research.

Funding for the consortium will support work at six disease study sites, which will examine conditions such as fatty liver diseases, hepatocellular carcinoma, asthma, chronic kidney disease and preeclampsia, among others.

The sites will enroll research participants, at least 75% of whom will be from ancestral backgrounds underrepresented in genomics research. The sites also will collect data on participants’ environments and social determinants of health to be used in conjunction with the multi-omics data. Combining the multi-omic and environmental data can offer an even more comprehensive view of the factors that contribute to disease risk and outcomes.

Specimens provided by participants will be processed at the omics production center at Washington University, which will use high-throughput molecular assays to generate genomics, epigenomics, transcriptomics, proteomics and metabolomics data that will be analyzed to generate molecular profiles of disease and non-disease states.

A data analysis and coordination center will then incorporate all of these data into large, organized datasets that will be made available to the scientific community for further studies.

This is a rare opportunity to bring together a bunch of scientists with highly complementary expertise. I expect it to inspire breakthroughs in leveraging multi-omics approaches to understand disease,” said Leah Shriver, a research associate professor of chemistry in Arts & Sciences and a co-investigator on the research team.

Multi-omics studies are at the forefront of biomedical research and promise to advance our understanding of disease onset and progression,” said Erin Ramos, deputy director of NHGRI’s Division of Genomic Medicine. “All while potentially providing important clues for treatment design and drug-discovery efforts. This new consortium is an important step in making those advances a reality.

The award is funded jointly by NHGRI, the National Cancer Institute and the National Institute of Environmental Health Sciences.

Washington University in St. Louis
 

Related content

Simultaneous Analysis of Residual Pesticides Using High-Speed Scan and Smart SIM+ of GCMS-QP2050

Applications
| 2024 | Shimadzu
Instrumentation
GC/MSD, GC/SQ
Manufacturer
Shimadzu
Industries
Food & Agriculture

Agilent 8850 GC system

Brochures and specifications
| 2024 | Agilent Technologies
Instrumentation
GC
Manufacturer
Agilent Technologies
Industries
Others

GC/GC-MS Glass Insert/Liner Selection Guide

Guides
| 2024 | Shimadzu
Instrumentation
Consumables, GC, GC/MSD
Manufacturer
Shimadzu
Industries
Others

Improving Battery Production Yield, Performance, and Stability Using FTIR

Applications
| 2024 | Agilent Technologies
Instrumentation
FTIR Spectroscopy
Manufacturer
Agilent Technologies
Industries
Energy & Chemicals , Materials Testing

An advanced integrated GC-MS/MS and LC-MS/MS workflow for the comprehensive analysis of pesticide residues in food

Applications
| 2024 | Thermo Fisher Scientific
Instrumentation
GC/MSD, GC/MS/MS, GC/QQQ, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Thermo Fisher Scientific
Industries
Food & Agriculture
 

Related articles


Article | Upcoming events

Cal State LA hosts 15th Multidimensional Chromatography Workshop

This January, Cal State LA became a hub for scientists and researchers as it hosted the 15th Multidimensional Chromatography Workshop.
Complex Chemical Composition Analysis Lab (C³AL)
more

Article | Academy

Free NIST Data Processing Software Lab for Universities - Part 10: AMDIS Difficulties and Ways to Overcome Them in Free Laboratory Resource for Universities

In the tenth part, we will look at difficulties with AMDIS and ways to overcome them
James Little/Mass Spec Interpretation Services
more

Article | Scientific article

An innovative approach to planar chiral substances

New highly efficient method for the preparation of planar chiral compounds based on organocatalytic desymmetrization was published in Nature Communications
Katedra organické chemie Přírodovědecké fakulty Univerzity Karlovy
more

Article | Software

From a scientific project to a global business venture. The company mzio is striving to improve data analysis in mass spectrometry labs

A piece of software which enables researchers worldwide to speed up their work and helps them make scientific discoveries is expanding from science into commerce.
Ústav organické chemie a biochemie AV ČR
more
 

Related content

Simultaneous Analysis of Residual Pesticides Using High-Speed Scan and Smart SIM+ of GCMS-QP2050

Applications
| 2024 | Shimadzu
Instrumentation
GC/MSD, GC/SQ
Manufacturer
Shimadzu
Industries
Food & Agriculture

Agilent 8850 GC system

Brochures and specifications
| 2024 | Agilent Technologies
Instrumentation
GC
Manufacturer
Agilent Technologies
Industries
Others

GC/GC-MS Glass Insert/Liner Selection Guide

Guides
| 2024 | Shimadzu
Instrumentation
Consumables, GC, GC/MSD
Manufacturer
Shimadzu
Industries
Others

Improving Battery Production Yield, Performance, and Stability Using FTIR

Applications
| 2024 | Agilent Technologies
Instrumentation
FTIR Spectroscopy
Manufacturer
Agilent Technologies
Industries
Energy & Chemicals , Materials Testing

An advanced integrated GC-MS/MS and LC-MS/MS workflow for the comprehensive analysis of pesticide residues in food

Applications
| 2024 | Thermo Fisher Scientific
Instrumentation
GC/MSD, GC/MS/MS, GC/QQQ, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Thermo Fisher Scientific
Industries
Food & Agriculture
 

Related articles


Article | Upcoming events

Cal State LA hosts 15th Multidimensional Chromatography Workshop

This January, Cal State LA became a hub for scientists and researchers as it hosted the 15th Multidimensional Chromatography Workshop.
Complex Chemical Composition Analysis Lab (C³AL)
more

Article | Academy

Free NIST Data Processing Software Lab for Universities - Part 10: AMDIS Difficulties and Ways to Overcome Them in Free Laboratory Resource for Universities

In the tenth part, we will look at difficulties with AMDIS and ways to overcome them
James Little/Mass Spec Interpretation Services
more

Article | Scientific article

An innovative approach to planar chiral substances

New highly efficient method for the preparation of planar chiral compounds based on organocatalytic desymmetrization was published in Nature Communications
Katedra organické chemie Přírodovědecké fakulty Univerzity Karlovy
more

Article | Software

From a scientific project to a global business venture. The company mzio is striving to improve data analysis in mass spectrometry labs

A piece of software which enables researchers worldwide to speed up their work and helps them make scientific discoveries is expanding from science into commerce.
Ústav organické chemie a biochemie AV ČR
more
 

Related content

Simultaneous Analysis of Residual Pesticides Using High-Speed Scan and Smart SIM+ of GCMS-QP2050

Applications
| 2024 | Shimadzu
Instrumentation
GC/MSD, GC/SQ
Manufacturer
Shimadzu
Industries
Food & Agriculture

Agilent 8850 GC system

Brochures and specifications
| 2024 | Agilent Technologies
Instrumentation
GC
Manufacturer
Agilent Technologies
Industries
Others

GC/GC-MS Glass Insert/Liner Selection Guide

Guides
| 2024 | Shimadzu
Instrumentation
Consumables, GC, GC/MSD
Manufacturer
Shimadzu
Industries
Others

Improving Battery Production Yield, Performance, and Stability Using FTIR

Applications
| 2024 | Agilent Technologies
Instrumentation
FTIR Spectroscopy
Manufacturer
Agilent Technologies
Industries
Energy & Chemicals , Materials Testing

An advanced integrated GC-MS/MS and LC-MS/MS workflow for the comprehensive analysis of pesticide residues in food

Applications
| 2024 | Thermo Fisher Scientific
Instrumentation
GC/MSD, GC/MS/MS, GC/QQQ, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Thermo Fisher Scientific
Industries
Food & Agriculture
 

Related articles


Article | Upcoming events

Cal State LA hosts 15th Multidimensional Chromatography Workshop

This January, Cal State LA became a hub for scientists and researchers as it hosted the 15th Multidimensional Chromatography Workshop.
Complex Chemical Composition Analysis Lab (C³AL)
more

Article | Academy

Free NIST Data Processing Software Lab for Universities - Part 10: AMDIS Difficulties and Ways to Overcome Them in Free Laboratory Resource for Universities

In the tenth part, we will look at difficulties with AMDIS and ways to overcome them
James Little/Mass Spec Interpretation Services
more

Article | Scientific article

An innovative approach to planar chiral substances

New highly efficient method for the preparation of planar chiral compounds based on organocatalytic desymmetrization was published in Nature Communications
Katedra organické chemie Přírodovědecké fakulty Univerzity Karlovy
more

Article | Software

From a scientific project to a global business venture. The company mzio is striving to improve data analysis in mass spectrometry labs

A piece of software which enables researchers worldwide to speed up their work and helps them make scientific discoveries is expanding from science into commerce.
Ústav organické chemie a biochemie AV ČR
more
 

Related content

Simultaneous Analysis of Residual Pesticides Using High-Speed Scan and Smart SIM+ of GCMS-QP2050

Applications
| 2024 | Shimadzu
Instrumentation
GC/MSD, GC/SQ
Manufacturer
Shimadzu
Industries
Food & Agriculture

Agilent 8850 GC system

Brochures and specifications
| 2024 | Agilent Technologies
Instrumentation
GC
Manufacturer
Agilent Technologies
Industries
Others

GC/GC-MS Glass Insert/Liner Selection Guide

Guides
| 2024 | Shimadzu
Instrumentation
Consumables, GC, GC/MSD
Manufacturer
Shimadzu
Industries
Others

Improving Battery Production Yield, Performance, and Stability Using FTIR

Applications
| 2024 | Agilent Technologies
Instrumentation
FTIR Spectroscopy
Manufacturer
Agilent Technologies
Industries
Energy & Chemicals , Materials Testing

An advanced integrated GC-MS/MS and LC-MS/MS workflow for the comprehensive analysis of pesticide residues in food

Applications
| 2024 | Thermo Fisher Scientific
Instrumentation
GC/MSD, GC/MS/MS, GC/QQQ, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Thermo Fisher Scientific
Industries
Food & Agriculture
 

Related articles


Article | Upcoming events

Cal State LA hosts 15th Multidimensional Chromatography Workshop

This January, Cal State LA became a hub for scientists and researchers as it hosted the 15th Multidimensional Chromatography Workshop.
Complex Chemical Composition Analysis Lab (C³AL)
more

Article | Academy

Free NIST Data Processing Software Lab for Universities - Part 10: AMDIS Difficulties and Ways to Overcome Them in Free Laboratory Resource for Universities

In the tenth part, we will look at difficulties with AMDIS and ways to overcome them
James Little/Mass Spec Interpretation Services
more

Article | Scientific article

An innovative approach to planar chiral substances

New highly efficient method for the preparation of planar chiral compounds based on organocatalytic desymmetrization was published in Nature Communications
Katedra organické chemie Přírodovědecké fakulty Univerzity Karlovy
more

Article | Software

From a scientific project to a global business venture. The company mzio is striving to improve data analysis in mass spectrometry labs

A piece of software which enables researchers worldwide to speed up their work and helps them make scientific discoveries is expanding from science into commerce.
Ústav organické chemie a biochemie AV ČR
more
Other projects
Follow us
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike