Impurity Profiling of Pharmaceutical Starting Materials Using Gas Chromatography Coupled with High- Resolution Accurate Mass Spectrometry
Applications | 2016 | Thermo Fisher ScientificInstrumentation
GC/MSD, GC/MS/MS, GC/HRMS, GC/Orbitrap
IndustriesPharma & Biopharma
ManufacturerThermo Fisher Scientific
Key wordsmass, pci, δppm, impurities, starting, exactive, impurity, pharmaceutical, intermediate, exact, measured, compound, using, materials, active, were, accurate, methanol, chemical, api, resolution, orbitrap, manufacturing, identification, scan, high, background, used, elemental, performed, solid, structural, profiling, allowing, ions, thermo, full, number, experiments, spectrometer, tracefinder, chemicals, filtering, ingredient, spectrometry, apci, reliable, tool, score, liquid
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and accurate differential analysis to be performed to isolate unique features in extracts. Routine mass resolution of 60,000 FWHM and consistent sub-ppm mass accuracy ensures selective and confident compound detection and identification. POSTER NOTE Introduction The investigation of potentially toxic…
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Dominic Roberts1, Andrew Feilden2, Richard Barlow2, Jason Cole1, Alexander Semyonov1, Kyle D’Silva1, and Paul Silcock1 1 Thermo Fisher Scientific, Runcorn, UK; 2Smithers Rapra, Shawbury, UK. Poster Note 64741 Identification of Leachable Impurities from Pharmaceutical Container Closure Materials Using Orbitrap based…
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